Chemo-preventive properties of extracts from blueberries, jabuticabas and cinnamon isolated or combined with probiotics

• Grant number: 18/05315-3
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: October 01, 2018
• End date: September 30, 2019
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Engineering
• Principal Investigator: Carmen Sílvia Fávaro Trindade
• Grantee: Augusto Tasch Holkem
• Supervisor: Monique Lacroix
• Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
• Institution abroad: Institut National de la Recherche Scientifique (INRS), Canada
• Associated to the scholarship: 15/19375-0 - Coencapsulation of probiotics and proanthocyanidin-rich extract obtained from cinnamon (Cinnamomum zeylanicum Blume), BP.DR

Abstract

Colorectal cancer (CRC) is among the most frequent types in the world population. The increase in the development of this disease is mainly in eating habits. Evidence shows that the composition of the intestinal microbiota may be associated with the development of CRC and other dysbioses. Modulation of the gut by probiotics and phenolic compounds alone or in combination could positively influence the immune system and is beneficial in the preserving of CRC. The association of probiotics and phenolics presents great potential since some studies have suggested that there is a synergy among them. The objective of this project will be to investigate the chemoprotective effect of extracts from blueberries, jabuticabas and cinnamon isolated or together with probiotics against CRC cells development. The project will be carried out following antiproliferative, apoptosis, anti-radical and quinone reductase assays. No research addressing the chemoprevention effects of these extracts together with probiotics on CRC cells was found in the literature, which allows us to intuit that this is an innovative proposal.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, MARLUCI P.; THOMAZINI, MARCELO; HOLKEM, AUGUSTO T.; PINHO, LORENA S.; GENOVESE, MARIA I.; FAVARO-TRINDADE, CARMEN S.. Production and characterization of solid lipid microparticles loaded with guarana (Paullinia cupana) seed extract. Food Research International, v. 123, p. 144-152, SEP 2019. (18/05315-3, 16/24895-5, 16/24916-2, 15/19375-0)

HOLKEM, AUGUSTO TASCH; DA SILVA, MARLUCI PALAZZOLLI; FAVARO-TRINDADE, CARMEN SILVIA. Probiotics and plant extracts: a promising synergy and delivery systems. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, v. N/A, p. 19-pg., 2022-04-16. (15/19375-0, 16/24895-5, 18/05315-3, 19/09757-3)

HOLKEM, AUGUSTO TASCH; FAVARO-TRINDADE, CARMEN SILVIA; LACROIX, MONIQUE. Study of anticancer properties of proanthocyanidin-rich cinnamon extract in combination with Bifidobacterium animalis subsp. lactis BLC1 and resistance of these free and co-encapsulated materials under in vitro simulated gastrointestinal conditions. Food Research International, v. 134, AUG 2020. (18/05315-3, 15/19375-0)

HOLKEM, AUGUSTO TASCH; FAVARO-TRINDADE, CARMEN SILVIA. Potential of solid lipid microparticles covered by the protein-polysaccharide complex for protection of probiotics and proanthocyanidin-rich cinnamon extract. Food Research International, v. 136, OCT 2020. (18/05315-3, 15/19375-0)

DE SOUZA, VOLNEI BRITO; HOLKEM, AUGUSTO TASCH; THOMAZINI, MARCELO; PETTA, TANIA; TULINI, FABRICIO LUIZ; DE OLIVEIRA, CARLOS AUGUSTO FERNANDES; GENOVESE, MARIA INES; DA COSTA RODRIGUES, CHRISTIANNE ELISABETE; FAVARO TRINDADE, CARMEN SILVIA. Study of extraction kinetics and characterization of proanthocyanidin-rich extract from Ceylon cinnamon (Cinnamomum zeylanicum). JOURNAL OF FOOD PROCESSING AND PRESERVATION, v. 45, n. 5, MAR 2021. (13/24874-0, 14/14540-0, 18/05315-3, 13/09090-2, 15/19375-0)