Synthesis, characterization and study of cationic amphiphilic derivatives of chitosan as biofungicides

• Grant number: 10/13942-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2010
• End date: September 30, 2011
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Vera Aparecida de Oliveira Tiera
• Grantee: Juliana dos Santos Gabriel
• Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil

Abstract

In the structure of chitosan, two groups have high susceptibility to react by nucleophilic attack: the amino groups and / or acetamide and hydroxyl groups of the ring. The hydroxyl groups can be modified by replacing the hydrogen atoms, but its reactivity is lower than that of the amino group. Other reactions may also be carried out in order to selectively modify the free amino groups, aiming to change the properties of chitosan. Thus, the aims of this project are: I) Synthesis and characterization of polysaccharides containing varying proportions of hydrophilic and hydrophobic groups. II) The second step involves the study of the derivatives focusing their ability to self-associate in aqueous solution as well as their antifungal activity against the gus "Aspergillus flavus". (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GABRIEL, JULIANA DOS SANTOS; TIERA, MARCIO JOSE; DE OLIVEIRA TIERA, VERA APARECIDA. Synthesis, Characterization, and Antifungal Activities of Amphiphilic Derivatives of Diethylaminoethyl Chitosan against Aspergillus flavus. Journal of Agricultural and Food Chemistry, v. 63, n. 24, p. 5725-5731, JUN 24 2015. (10/13942-6, 12/03619-9)