Bioactivity behaviour of nano-hydroxyapatite/freestanding aligned carbon nanotube oxide composite

Author(s)

Siqueira, Idalia A. W. B. ^[1] ; Oliveira, Ciliana A. G. S. ^[1] ; Zanin, Hudson ^[2] ; Grinet, Marco A. V. M. ^[1] ; Granato, Alessandro E. C. ^[3] ; Porcionatto, Marimelia A. ^[3] ; Marciano, Fernanda R. ^[1] ; Lobo, Anderson O. ^[1]

Affiliation

^[1] Univ Vale Paraiba, Inst Res & Dev IP&D, Lab Biomed Nanotechnol, BR-12224000 Sao Paulo - Brazil

^[2] Univ Vale Paraiba, Inst Res & Dev IP&D, Lab Energy Storage & Supply ES&S, BR-12224000 Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Neurobiol Lab, BR-04049032 Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE; v. 26, n. 2 FEB 2015.
• Web of Science Citations: 5

Abstract

Bioactive and low cytotoxic three dimensional nano-hydroxyapatite (nHAp) and aligned carbon nanotube oxide (a-CNTO) composite has been investigated. First, freestanding aligned carbon nanotubes porous scaffold was prepared by large-scale thermal chemical vapour deposition and functionalized by oxygen plasma treatment, forming a-CNTO. The a-CNTO was covered with plate-like nHAp crystals prepared by in situ electrodeposition techniques, forming nHAp/a-CNTO composite. After that nHAp/a-CNTO composite was immersed in simulated body fluid for composite consolidation. This novel nanobiomaterial promotes mesenchymal stem cell adhesion with the active formation of membrane projections, cell monolayer formation and high cell viability. (AU)

• FAPESP's process: 11/20345-7 - Study of nanoparticle-incorporated diamond-like carbon films for biomedical applications
• Grantee: Fernanda Roberta Marciano
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 14/02163-7 - Development of supercapacitors devices from graphene, carbon nanotubes and diamonds
• Grantee: Hudson Giovani Zanin
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 13/07696-0 - Production of polymeric scaffolds by rotary-jet-spinning technique with incorporated carbon nanotubes
• Grantee: Marco Antonio Vieira Macedo Grinet
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration
• Grantee: Anderson de Oliveira Lobo
• Support Opportunities: Research Grants - Young Investigators Grants