Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

High loading of graphene oxide/multi-walled carbon nanotubes into PDLLA: A route towards the design of osteoconductive, bactericidal and non-immunogenic 3D porous scaffolds

Full text
Author(s):
Zanin, Hudson [1, 2] ; Manzolli Rodrigues, Bruno Vinicius [1] ; Ribeiro Neto, Wilson Alves [3] ; Suman Bretas, Rosario Elida [3] ; Da-Silva, Newton Soares [4] ; Marciano, Fernanda Roberta [1] ; Lobo, Anderson Oliveira [1]
Total Authors: 7
Affiliation:
[1] Univ Vale Paraiba, Inst Res & Dev, Lab Biomed Nanotechnol Nanobio, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, SP - Brazil
[2] Univ Vale Paraiba, Inst Res & Dev, Lab Energy Storage & Supply ES&S, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Mat Engn, Rodovia Washington Luis, Km 235, SP-310, Sao Carlos, SP - Brazil
[4] Univ Vale Paraiba, Lab Cell Biol & Tissue, Inst Res & Dev, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Materials Chemistry and Physics; v. 177, p. 56-66, JUL 1 2016.
Web of Science Citations: 4
Abstract

We have prepared a novel 3D porous biomaterial combining poly (DL-lactic acid) (PDLLA) and graphene and multi-walled carbon nanotubes oxides (MWCNTO-GO) composite. PDLLA as control and a high loading of PDLLA/MWCNTO-GO (50/50 w/w) bioscaffolds were prepared and functionalized. MWCNTs were exfoliated to form MWCNTO-GO by oxygen plasma etching. The later was also applied to enhance the scaffolds wettability, attaching oxygen-containing groups on their surfaces. This approach produced a porous architecture observed by scanning electron microscopy and semi-quantified by electrochemical analysis. The later also indicated a notable increase on the conductivity of PDLLA/MWCNTO-GO scaffold compared to MWCNTO-GO free PDLLA (about 5 orders of magnitudes at low frequencies). Thermogravimetric analysis showed that the MWCNTO-GO acted protecting the PDLLA matrix, enhancing its thermal stability. The PDLLA/MWCNTO-GO scaffolds had significant cellular adhesion, did not present cytotoxicity effect, besides reduced bactericidal proliferation and produced mineralized tissues in SBF media. The metallic MWCNTO-GO powder held together by PDLLA polymer opens a whole new branch of applications, including bioelectroanalyses, drug delivery systems and tissue engineering. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/20345-7 - Study of nanoparticle-incorporated diamond-like carbon films for biomedical applications
Grantee:Fernanda Roberta Marciano
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/08523-8 - Development of a fluorescent nanosensor from the electrospinning of PVA and graphene quantum dots: application in the detection of Alzheimer's biomarkers
Grantee:Bruno Vinícius Manzolli Rodrigues
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration
Grantee:Anderson de Oliveira Lobo
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/01259-3 - Electrospinning by solution of PBAT built nanohidroxiapatita
Grantee:Aline dos Santos Silva
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 14/02163-7 - Development of supercapacitors devices from graphene, carbon nanotubes and diamonds
Grantee:Hudson Giovani Zanin
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 13/20054-8 - Studies of adhesion, proliferation and cell death in the interaction of cells with nanostructured materials
Grantee:Newton Soares da Silva
Support type: Regular Research Grants