| Full text | |
| Author(s): |
Zanin, Hudson
[1, 2]
;
Manzolli Rodrigues, Bruno Vinicius
[1]
;
Ribeiro Neto, Wilson Alves
[3]
;
Suman Bretas, Rosario Elida
[3]
;
Da-Silva, Newton Soares
[4]
;
Marciano, Fernanda Roberta
[1]
;
Lobo, Anderson Oliveira
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Vale Paraiba, Inst Res & Dev, Lab Biomed Nanotechnol Nanobio, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, SP - Brazil
[2] Univ Vale Paraiba, Inst Res & Dev, Lab Energy Storage & Supply ES&S, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Mat Engn, Rodovia Washington Luis, Km 235, SP-310, Sao Carlos, SP - Brazil
[4] Univ Vale Paraiba, Lab Cell Biol & Tissue, Inst Res & Dev, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Materials Chemistry and Physics; v. 177, p. 56-66, JUL 1 2016. |
| Web of Science Citations: | 4 |
| Abstract | |
We have prepared a novel 3D porous biomaterial combining poly (DL-lactic acid) (PDLLA) and graphene and multi-walled carbon nanotubes oxides (MWCNTO-GO) composite. PDLLA as control and a high loading of PDLLA/MWCNTO-GO (50/50 w/w) bioscaffolds were prepared and functionalized. MWCNTs were exfoliated to form MWCNTO-GO by oxygen plasma etching. The later was also applied to enhance the scaffolds wettability, attaching oxygen-containing groups on their surfaces. This approach produced a porous architecture observed by scanning electron microscopy and semi-quantified by electrochemical analysis. The later also indicated a notable increase on the conductivity of PDLLA/MWCNTO-GO scaffold compared to MWCNTO-GO free PDLLA (about 5 orders of magnitudes at low frequencies). Thermogravimetric analysis showed that the MWCNTO-GO acted protecting the PDLLA matrix, enhancing its thermal stability. The PDLLA/MWCNTO-GO scaffolds had significant cellular adhesion, did not present cytotoxicity effect, besides reduced bactericidal proliferation and produced mineralized tissues in SBF media. The metallic MWCNTO-GO powder held together by PDLLA polymer opens a whole new branch of applications, including bioelectroanalyses, drug delivery systems and tissue engineering. (C) 2016 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration |
| Grantee: | Anderson de Oliveira Lobo |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 11/20345-7 - Study of nanoparticle-incorporated diamond-like carbon films for biomedical applications |
| Grantee: | Fernanda Roberta Marciano |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 15/01259-3 - Electrospinning by solution of PBAT built nanohidroxiapatita |
| Grantee: | Aline dos Santos Silva |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 13/20054-8 - Studies of adhesion, proliferation and cell death in the interaction of cells with nanostructured materials |
| Grantee: | Newton Soares da Silva |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/02163-7 - Development of supercapacitors devices from graphene, carbon nanotubes and diamonds |
| Grantee: | Hudson Giovani Zanin |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 15/08523-8 - Development of a fluorescent nanosensor from the electrospinning of PVA and graphene quantum dots: application in the detection of Alzheimer's biomarkers |
| Grantee: | Bruno Vinícius Manzolli Rodrigues |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |