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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial activity against Gram-positive and Gram-negative bacteria during gatifloxacin degradation by hydroxyl radicals

Full text
Author(s):
Caianelo, Marlon ; Rodrigues-Silva, Caio ; Maniero, Milena Guedes ; Guimaraes, Jose Roberto
Total Authors: 4
Document type: Journal article
Source: Environmental Science and Pollution Research; v. 24, n. 7, p. 6288-6298, MAR 2017.
Web of Science Citations: 9
Abstract

Gatifloxacin, an antimicrobial drug belonging to the fluoroquinolone family, is active against Gram-positive and Gram-negative bacteria and is extensively used for the control of infections in humans. The presence of the drug in environmental matrices has already been reported. This study investigated the degradation of gatifloxacin in water by hydroxyl radicals generated by the UV254 nm/H2O2 process (CH2O2initial = 0.4-2.4 mmol L-1) and evaluated the capacity of the radicals to reduce the antimicrobial activity against Gram-positive and Gram-negative bacteria. Acute toxicity assays were performed with Vibrio fischeri, and the degradation products were proposed. The hydroxyl radicals formed in the processes were able to degrade the fluoroquinolone and remove the antimicrobial activity from the aqueous solution. Approximately 97 % gatifloxacin degradation was observed after applying 2.4 mmol L-1 of initial H2O2 concentration and 20 min of UVC254nm irradiation (130 J s(-1)). The acute toxicity assays showed that the toxicity of the treated solution for V. fischeri increased as the gatifloxacin concentration in the solution decreased. (AU)

FAPESP's process: 13/04656-8 - Degradation of pharmaceuticals by peroxidation combined with ultraviolet radiation and ozonation: antimicrobial activity and toxicity
Grantee:José Roberto Guimarães
Support type: Regular Research Grants
FAPESP's process: 13/09543-7 - Residues of veterinary drugs in the environment
Grantee:Susanne Rath
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/06064-3 - Multi-User Equipment aproved in grant 2013/09543-7: ultra high performance liquid chromatography with photodiode array detector and Fluorescence Detector (UPLC-DAD-FLD)
Grantee:Susanne Rath
Support type: Multi-user Equipment Program
FAPESP's process: 14/16622-3 - Identification of intermediates formed during degradation of veterinary drugs by advanced oxidation processes
Grantee:Caio Alexandre Augusto Rodrigues da Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/07817-2 - Degradation of sulfonamides and tetraciclines by UV/H2O2 and O3: evaluation of antimicrobial activity and toxicity
Grantee:Milena Guedes Maniero Ferreira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/06201-0 - Multi-equipment aproved in grant 2013/09543-7: ultra high performance liquid chromatograph coupled to a photodiode array detector and tandem mass spectrometer (UPLC-DAD-MS/MS)
Grantee:Susanne Rath
Support type: Multi-user Equipment Program