Evaluation of a novel composite based on functionalized multi-walled carbon nanotube and iron phthalocyanine for electroanalytical determination of isoniazid

Author(s)

Spindola, Rolff Ferreira ; Zanin, Hudson ; Macena, Cleidivan Silva ; Contin, Andre ; Silva Luz, Rita de Cassia ; Damos, Flavio Santos

• Document type: Journal article
• Source: Journal of Solid State Electrochemistry; v. 21, n. 4, p. 1089-1099, APR 2017.
• Web of Science Citations: 8

Abstract

A novel platform for electroanalysis of isoniazid based on graphene-functionalized multi-walled carbon nanotube as support for iron phthalocyanine (FePc/f-MWCNT) has been developed. The FePc/f-MWCNT composite has been dropped on glassy carbon forming FePc/f-MWCNT/GC electrode, which is sensible for isoniazid, decreasing substantially its oxidation potential to +200 mV vs Ag/AgCl. Electrochemical and electroanalytical properties of the FePc/f-MWCNT/GC-modified electrode were investigated by cyclic voltammetry, electrochemical impedance spectroscopy, scanning electrochemical microscopy, and amperometry. The sensor presents better performance in 0.1 mol L-1 phosphate buffer at pH 7.4. Under optimized conditions, a linear response range from 5 to 476 mu mol L-1 was obtained with a limit of detection and sensitivity of 0.56 mu mol L-1 and 0.023 mu A L mu mol(-1), respectively. The relative standard deviation for 10 determinations of 100 mu mol L-1 isoniazid was 2.5%. The sensor was successfully applied for isoniazid selective determination in simulated body fluids. (AU)

• FAPESP's process: 14/02163-7 - Development of supercapacitors devices from graphene, carbon nanotubes and diamonds
• Grantee: Hudson Giovani Zanin
• Support Opportunities: Research Grants - Young Investigators Grants