| Full text | |
| Author(s): |
Perim, Pedro
[1]
;
Marticorena, Felipe Miguel
[1]
;
Ribeiro, Felipe
[1]
;
Barreto, Gabriel
[1]
;
Gobbi, Nathan
[1]
;
Kerksick, Chad
[2]
;
Dolan, Eimear
[1]
;
Saunders, Bryan
[3, 1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Sch Phys Educ & Sport, Rheumatol Div, Appl Physiol & Nutr Res Grp, Fac Med FMUSR, Sao Paulo - Brazil
[2] Lindenwood Univ, Exercise & Performance Nutr Lab, St Charles, MO - USA
[3] Univ Sao Paulo, Inst Orthopaed & Traumatol, Fac Med FMUSP, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | FRONTIERS IN NUTRITION; v. 6, AUG 27 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Carnosine is an abundant histidine-containing dipeptide in human skeletal muscle and formed by beta-alanine and L-histidine. It performs various physiological roles during exercise and has attracted strong interest in recent years with numerous investigations focused on increasing its intramuscular content to optimize its potential ergogenic benefits. Oral beta-alanine ingestion increases muscle carnosine content although large variation in response to supplementation exists and the amount of ingested beta-alanine converted into muscle carnosine appears to be low. Understanding of carnosine and beta-alanine metabolism and the factors that influence muscle carnosine synthesis with supplementation may provide insight into how beta-alanine supplementation may be optimized. Herein we discuss modifiable factors that may further enhance the increase of muscle carnosine in response to beta-alanine supplementation including, (i) dose; (ii) duration; (iii) beta-alanine formulation; (iv) dietary influences; (v) exercise; and (vi) co-supplementation with other substances. The aim of this narrative review is to outline the processes involved in muscle carnosine metabolism, discuss theoretical and mechanistic modifiable factors which may optimize the muscle carnosine response to beta-alanine supplementation and to make recommendations to guide future research. (AU) | |
| FAPESP's process: | 18/01594-5 - Blood and muscle responses to sodium bicarbonate supplementation and subsequent exercise performance |
| Grantee: | Pedro Henrique Lopes Perim |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 17/15314-1 - The influence of the CYP1A2 polymorphism on the physiological responses and performance following acute supplementation with caffeine |
| Grantee: | Gabriel Henrique Castanho Barreto |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 17/04973-4 - Nutritional supplementation and exercise to optimise exercise performance: focus on individual responses and a step towards personalized sports nutrition |
| Grantee: | Bryan Saunders |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition |
| Grantee: | Bryan Saunders |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 19/05616-6 - The bone response to exercise: a translational research program exploring clinical and mechanistic aspects |
| Grantee: | Eimear Bernadette Dolan |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 18/19981-5 - Influence of timing of creatine intake in relation to strength training on body composition, hypertrophy, and strength performance |
| Grantee: | Felipe Ribeiro Dainese Candido |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |