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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized?

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Author(s):
Perim, Pedro [1] ; Marticorena, Felipe Miguel [1] ; Ribeiro, Felipe [1] ; Barreto, Gabriel [1] ; Gobbi, Nathan [1] ; Kerksick, Chad [2] ; Dolan, Eimear [1] ; Saunders, Bryan [3, 1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Rheumatol Div, Appl Physiol & Nutr Res Grp, Fac Med FMUSR, Sao Paulo - Brazil
[2] Lindenwood Univ, Exercise & Performance Nutr Lab, St Charles, MO - USA
[3] Univ Sao Paulo, Inst Orthopaed & Traumatol, Fac Med FMUSP, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: FRONTIERS IN NUTRITION; v. 6, AUG 27 2019.
Web of Science Citations: 1
Abstract

Carnosine is an abundant histidine-containing dipeptide in human skeletal muscle and formed by beta-alanine and L-histidine. It performs various physiological roles during exercise and has attracted strong interest in recent years with numerous investigations focused on increasing its intramuscular content to optimize its potential ergogenic benefits. Oral beta-alanine ingestion increases muscle carnosine content although large variation in response to supplementation exists and the amount of ingested beta-alanine converted into muscle carnosine appears to be low. Understanding of carnosine and beta-alanine metabolism and the factors that influence muscle carnosine synthesis with supplementation may provide insight into how beta-alanine supplementation may be optimized. Herein we discuss modifiable factors that may further enhance the increase of muscle carnosine in response to beta-alanine supplementation including, (i) dose; (ii) duration; (iii) beta-alanine formulation; (iv) dietary influences; (v) exercise; and (vi) co-supplementation with other substances. The aim of this narrative review is to outline the processes involved in muscle carnosine metabolism, discuss theoretical and mechanistic modifiable factors which may optimize the muscle carnosine response to beta-alanine supplementation and to make recommendations to guide future research. (AU)

FAPESP's process: 19/05616-6 - The bone response to exercise: a translational research program exploring clinical and mechanistic aspects
Grantee:Eimear Bernadette Dolan
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 18/19981-5 - Influence of timing of creatine intake in relation to strength training on body composition, hypertrophy, and strength performance
Grantee:Felipe Ribeiro Dainese Candido
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/01594-5 - Blood and muscle responses to sodium bicarbonate supplementation and subsequent exercise performance
Grantee:Pedro Henrique Lopes Perim
Support type: Scholarships in Brazil - Master
FAPESP's process: 17/15314-1 - The influence of the CYP1A2 polymorphism on the physiological responses and performance following acute supplementation with caffeine
Grantee:Gabriel Henrique Castanho Barreto
Support type: Scholarships in Brazil - Master
FAPESP's process: 17/04973-4 - Nutritional supplementation and exercise to optimise exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Scholarships in Brazil - Young Researchers