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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19

Full text
Author(s):
Rogero, Marcelo M. [1, 2] ; Leao, Matheus de C. [3] ; Santana, Tamires M. [2, 3] ; Pimentel, Mariana V. de M. B. [3] ; Carlini, Giovanna C. G. [3] ; Silveira, Tayse F. F. da [3] ; Goncalves, Renata C. [4] ; Castro, Inar A. [2, 3]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Nutr Genom & Inflammat Lab, BR-01246904 Sao Paulo - Brazil
[2] Sao Paulo Res Fdn, Res Innovat & Disseminat Ctr, CEPID FAPESP, Food Res Ctr FoRC, BR-05468140 Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, LADAF, Av Lineu Prestes 580, B14, BR-05508900 Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Review article
Source: Free Radical Biology and Medicine; v. 156, p. 190-199, AUG 20 2020.
Web of Science Citations: 3
Abstract

Studies have shown that infection, excessive coagulation, cytokine storm, leukopenia, lymphopenia, hypoxemia and oxidative stress have also been observed in critically ill Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) patients in addition to the onset symptoms. There are still no approved drugs or vaccines. Dietary supplements could possibly improve the patient's recovery. Omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), present an anti-inflammatory effect that could ameliorate some patients need for intensive care unit (ICU) admission. EPA and DHA replace arachidonic acid (ARA) in the phospholipid membranes. When oxidized by enzymes, EPA and DHA contribute to the synthesis of less inflammatory eicosanoids and specialized pro-resolving lipid mediators (SPMs), such as resolvins, maresins and protectins. This reduces inflammation. In contrast, some studies have reported that EPA and DHA can make cell membranes more susceptible to non-enzymatic oxidation mediated by reactive oxygen species, leading to the formation of potentially toxic oxidation products and increasing the oxidative stress. Although the inflammatory resolution improved by EPA and DHA could contribute to the recovery of patients infected with SARS-CoV-2, Omega-3 fatty acids supplementation cannot be recommended before randomized and controlled trials are carried out. (AU)

FAPESP's process: 19/24023-6 - Chemical characterization of Echium plantagineum seed oil obtained by three process of extraction
Grantee:Giovanna Calixto Garcia Carlini
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/08066-1 - Application of phenolipids to increase oxidative stability of n-3 polyunsaturated fatty acids emulsions
Grantee:Tayse Ferreira Ferreira da Silveira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/07914-8 - FoRC - Food Research Center
Grantee:Bernadette Dora Gombossy de Melo Franco
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC