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Full text
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Author(s):
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Rezende, Nathalia Saffioti
[1]
;
Swinton, Paul
[2]
;
de Oliveira, Luana Farias
[1]
;
da Silva, Rafael Pires
[1]
;
da Eira Silva, Vinicius
[1]
;
Nemezio, Kleiner
[1]
;
Yamaguchi, Guilherme
[1]
;
Artioli, Guilherme Giannini
[1]
;
Gualano, Bruno
[3, 1]
;
Saunders, Bryan
[1]
;
Dolan, Eimear
[1]
Total Authors: 11
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| Affiliation: | [1] Univ Sao Paulo, Fac Med FMUSP, Appl Physiol & Nutr Res Grp, Sch Phys Educ & Sport, Rheumatol Div, Sao Paulo - Brazil
[2] Robert Gordon Univ, Sch Hlth Sci, Aberdeen - Scotland
[3] Univ Sao Paulo, Food Res Ctr, Sao Paulo - Brazil
Total Affiliations: 3
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| Document type: |
Review article
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| Source: |
FRONTIERS IN PHYSIOLOGY;
v. 11,
AUG 14 2020.
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| Web of Science Citations: |
0
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| Abstract |
Beta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and has many proven, and purported, ergogenic, and therapeutic benefits. Currently, many questions on the nature of the MCarn response to supplementation are open, and the response to these has considerable potential to enhance the efficacy and application of this supplementation strategy. To address these questions, we conducted a systematic review with Bayesian-based meta-analysis of all published aggregate data using a dose response (Emax) model. Meta-regression was used to consider the influence of potential moderators (including dose, sex, age, baseline MCarn, and analysis method used) on the primary outcome. The protocol was designed according to PRISMA guidelines and a three-step screening strategy was undertaken to identify studies that measured the MCarn response to BA supplementation. Additionally, we conducted an original analysis of all available individual data on the MCarn response to BA supplementation from studies conducted within our lab (n= 99). The Emax model indicated that human skeletal muscle has large capacity for non-linear MCarn accumulation, and that commonly used BA supplementation protocols may not come close to saturating muscle carnosine content. Neither baseline values, nor sex, appeared to influence subsequent response to supplementation. Analysis of individual data indicated that MCarn is relatively stable in the absence of intervention, and effectually all participants respond to BA supplementation (99.3% response {[}95%CrI: 96.2-100]). (AU) |
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| FAPESP's process: |
19/05616-6 - The bone response to exercise: a translational research program exploring clinical and mechanistic aspects
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| Grantee: | Eimear Bernadette Dolan |
| Support type: |
Research Grants - Young Investigators Grants
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| FAPESP's process: |
17/09635-0 - Factors determining the carnosine content of human skeletal muscle: Influence of age and sex
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| Grantee: | Eimear Bernadette Dolan |
| Support type: |
Scholarships in Brazil - Post-Doctorate
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| FAPESP's process: |
14/11948-8 - Life without carnosine: development and characterization of a KO rat model for studying the physiological role of carnosine and its implications to physical exercise and muscle metabolism
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| Grantee: | Guilherme Giannini Artioli |
| Support type: |
Research Grants - Young Investigators Grants
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| FAPESP's process: |
17/23688-9 - High-intensity intermittent training and beta-alanine supplementation: effects on carnosine metabolism in skeletal muscle and exercise performance and capacity
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| Grantee: | Rafael Pires da Silva |
| Support type: |
Scholarships in Brazil - Post-Doctorate
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| FAPESP's process: |
13/14746-4 - Carnosine metabolism in skeletal muscle: a multi-approach study
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| Grantee: | Bruno Gualano |
| Support type: |
Research Projects - Thematic Grants
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| FAPESP's process: |
15/23176-2 - The kinetics of muscle carnosine washout after beta-alanine supplementation
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| Grantee: | Guilherme de Carvalho Yamaguchi |
| Support type: |
Scholarships in Brazil - Master
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| FAPESP's process: |
19/27758-7 - To investigate the relationship between pH and bone metabolic markers during a prolonged exercise test interspersed with high-intensity sprints
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| Grantee: | Nathália Saffioti Rezende |
| Support type: |
Scholarships in Brazil - Scientific Initiation
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| FAPESP's process: |
17/04973-4 - Nutritional supplementation and exercise to optimise exercise performance: focus on individual responses and a step towards personalized sports nutrition
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| Grantee: | Bryan Saunders |
| Support type: |
Scholarships in Brazil - Young Researchers
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