| Full text | |
| Author(s): Show less - |
Mariacaterina Lianza
;
Maria Helena Verdan
[2]
;
Jean Paulo de Andrade
;
Ferruccio Poli
[4]
;
Larissa C. de Almeida
[5]
;
Leticia V. Costa-Lotufo
[6]
;
Álvaro Cunha Neto
[7]
;
Sarah C. C. Oliveira
[8]
;
Jaume Bastida
[9]
;
Andrea N. L. Batista
[10]
;
João M. Batista Jr.
[11]
;
Warley S. Borges
[12]
Total Authors: 12
|
| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 31, n. 10, p. 2135-2145, 2020-10-09. |
| Abstract | |
The phytochemical study of Hippeastrum goianum led to the identification of 13 compounds by means of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Compounds 7-demethoxy-9-O-methylhostasine (1) and 7-deoxi-trans-dihydronarciclasine (2) had their absolute configurations determined by vibrational circular dichroism (VCD). This is the first time that compound 1 is described in the Amaryllidaceae family. The cytotoxicity of all isolated compounds was tested against colorectal carcinoma (HCT 116), breast carcinoma (MCF-7), and non-tumor human retinal pigment epithelium (RPE) cell lines. The half-maximum inhibitory concentration (IC50) of compound 2 against each cell line was equivalent to the positive control (doxorubicin), indicating a considerable cytotoxic activity. (AU) | |
| FAPESP's process: | 15/17177-6 - Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds |
| Grantee: | Leticia Veras Costa Lotufo |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 14/25222-9 - Vibrational chiroptical spectroscopy for stereochemical characterization of small molecules and macromolecules |
| Grantee: | João Marcos Batista Junior |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/50926-0 - INCT 2014: biodiversity and natural products |
| Grantee: | Vanderlan da Silva Bolzani |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 18/17595-0 - Study of pradimicina-IRD molecular interaction with DNA and its tumor cell mechanism of action |
| Grantee: | Larissa Costa de Almeida |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |