Antiplatelet Effects of Bioactive Compounds Present in Tomato Pomace

Author(s)

Fuentes, Eduardo ^[1] ; Trostchansky, Andres ^{[2, 3]} ; Reguengo, Livia M. ^[4] ; Junior, Mario R. M. ^[4] ; Palomo, Ivan ^[1]

Affiliation

^[1] Univ Talca, Fac Hlth Sci, Thrombosis Res Ctr, Sch Med Technol, Dept Clin Biochem & Immunohae, Talca - Chile

^[2] Univ Republica, Fac Med, Dept Bioquim, Montevideo - Uruguay

^[3] Univ Republica, Fac Med, Ctr Free Radical & Biomed Res, Montevideo - Uruguay

^[4] Univ Campinas UNICAMP, Fac Food Engn, BR-13083970 Campinas, SP - Brazil

• Document type: Review article
• Source: CURRENT DRUG TARGETS; v. 22, n. 15, p. 1716-1724, 2021.
• Web of Science Citations: 0

Abstract

Cardiovascular diseases (CVD) currently account for nearly half of non-communicable diseases. Epidemiological studies have demonstrated the cardiovascular protective role of a diet rich in vegetables and fruits. In this context, our research outcomes have demonstrated the antiplatelet activities of fruits and vegetable extracts widely consumed, among which tomato was highlighted in our lab work. Tomato pomace, a major byproduct of tomato paste production, consists of skin and seeds and is a rich source of bioactive compounds. Tomato pomace has potent antithrombotic effects, even greater than the tomato. Given the large volumes of an industrial generation of tomato pomace, there is an opportunity to use this by-product to obtain a functional product with antiaggregant and antithrombotic properties that could be useful as an additive in health foods and thus prevent CVD. This review will focus on the platelet as the target for the antithrombotic actions exerted by the different bioactive compounds present in tomato pomace. (AU)

• FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
• Grantee: Glaucia Maria Pastore
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants