Brazilian Berry Extract Chemopreventive Action: Hormone Receptors as a Target to Mitigate Aging Prostatic Disorders.

Author(s)

Longo, Marjorie Barcha ; Lamas, Celina de Almeida ; Rossetto, Isabela Urra ; Nogueira-Lima, Ellen ; Collares-Busatto, Carla Beatriz ; Marostica Junior, Mario Roberto ; Alves Cagnon Quitete, Valeria Helena

• Document type: Journal article
• Source: Brazilian Archives of Biology and Technology; v. 66, p. 12-pg., 2023-01-01.

Abstract

The Brazilian berry, also known as jaboticaba, has a great antioxidant and anti-inflammatory potential, besides demonstrating positive effects on hormonal regulation and weight loss. Nowadays, both aging and overweight are considered public health issues, promoting metabolic and hormonal changes that have a substantial role in prostate injury. We demonstrated herein that a low dose of jaboticaba peel extract (PJE) is enough to limit the onset of damages and hormone receptor alterations on the anterior prostate in the senile or high-fat diet (HFD) groups. The senile mice (11-months old) received the PJE and/or a HFD for 60 days. The anterior prostates were collected for histopathological, immunohistochemistry and western -blotting analysis. The PJE treatment reduced the epithelium atrophy and inflammatory infiltrate frequencies besides decreasing the androgen receptor (AR); estrogen receptor alpha (ER alpha); and insulin-like growth factor 1 receptor (IGFR-1) immunoexpression; in the anterior prostate of both senile and HFD-senile mice. However, low prostatic intraepithelial neoplasia (PIN) frequency, reduced immunoexpression of stromal AR and epithelium IGFR-1 were only observed in the anterior prostate of the PJE and HFD-treated groups. HFD intake intensified the aging-induced histopathological and hormonal alterations by further increasing the AR, ER alpha and IGFR-1 immunoexpression, as well as the PIN lesion incidence in the anterior prostate. Thus, the PJE was able to interfere in the hormonal signaling mediators, protecting the anterior prostate microenvironment and preventing lesion development due to aging associated or not with HFD intake. (AU)

• FAPESP's process: 15/25714-1 - Effects of jaboticaba peel extract therapy on the prostate biology and metabolic parameters of the mice FVB in relation to aging and hyperlipidic diet
• Grantee: Valéria Helena Alves Cagnon Quitete
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/24793-5 - Morphology and MMP-9, AR and IFGR-1 evaluation on the anterior prostate lobe of the aging mice (FVB) submitted to hyperlipidic diet and treated with Jaboticaba peel extract
• Grantee: Marjorie Barcha Longo
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 18/04579-7 - Jaboticaba Extract: In vivo response of prostatic adenocarcinoma in TRAMP mice associated with hyperlipic diet intake and in vitro response of tumoral human prostatic cells
• Grantee: Valéria Helena Alves Cagnon Quitete
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
• Grantee: Glaucia Maria Pastore
• Support Opportunities: Research Projects - Thematic Grants