Freeze-dried jaboticaba (Myrciaria jaboticaba) peel powder, a rich source of anthocyanins and phenolic acids, mitigates inflammation-driven colorectal cancer in mice

Author(s):Show less -

do Nascimento, Roberto de Paula ; Rizzato, Julia Soto ; Polezi, Gabriele ; Moya, Amanda Maria Tomazini Munhoz ; Silva, Milena Ferreira ; Machado, Ana Paula da Fonseca ; Franchi Junior, Gilberto Carlos ; Borguini, Renata Galhardo ; Santiago, Manuela Cristina Pessanha de Araujo ; Paiotti, Ana Paula Ribeiro ; Pereira, Jose Aires ; Martinez, Carlos Augusto Real ; Marostica Junior, Mario Roberto

• Document type: Journal article
• Source: FOOD BIOSCIENCE; v. 53, p. 10-pg., 2023-04-05.

Abstract

This study aimed to characterize the peel of jaboticaba (Myrciaria jaboticaba (Vell.) O. Berg) by spectrophotometry and chromatography, and investigate its effects on mice with inflammation-driven colorectal cancer (CRC). Freeze-dried jaboticaba peel (FDJP) showed a high antioxidant capacity in vitro, and to be mostly a source of cyanidin-3-O-glucoside, gallic acid, and ellagic acid. In the animal bioassay, FDJP added at 5% in the diet during 114 days completely abolished the formation of adenocarcinoma, which had an incidence of 75% in the non-treated group. Animals consuming FDJP showed low histology damage regarding inflammatory infiltrate, edema, and crypt distortion. FDJP significantly reduced the colonic levels of proinflammatory markers interleukin-1beta and cyclooxygenase-2, and demonstrated a probability to decrease the expressions of inducible nitric oxide synthase and nuclear factor kappa B. In summary, FDJP mitigated CRC, possibly by avoiding triggering inflammation. Such benefit may come from its rich content in anthocyanins and phenolic acids. (AU)

• FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/00414-3 - Preventive effects of freeze-dried jaboticaba peel on experimental colorectal cancer model: clinical and histophysiopathological evaluation
• Grantee: Julia Soto Rizzato
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/03228-9 - Preventive effects of the consumption of freeze-dried jaboticaba peel in BALB/c mice with Colorectal Cancer induced by azoxymethane/dextran sodium sulfate
• Grantee: Roberto de Paula do Nascimento
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
• Grantee: Glaucia Maria Pastore
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/23657-6 - Development of microparticles containing grape skin extract through the emerging technique SAS and evaluation of their antioxidant and anti-inflammatory effects in the treatment of induced Colitis in rats
• Grantee: Ana Paula da Fonseca Machado
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants