No Associations Between Physical Activity and Immunogenicity in SARS-CoV-2 Seropositive Patients With Autoimmune Rheumatic Diseases Prior to and After Vaccination

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Smaira, Fabiana Infante ; Mazzolani, Bruna Caruso ; Lemes, italo Ribeiro ; da Silva, Rafael Pires ; Pinto, Ana J. ; Sieczkowska, Sofia M. ; Aikawa, Nadia E. ; Pasoto, Sandra G. ; Medeiros-Ribeiro, Ana C. ; Saad, Carla G. S. ; Yuk, Emily F. N. ; Silva, Clovis A. ; Swinton, Paul ; Kupa, Leonard de Vinci Kanda ; Hallal, Pedro C. ; Roschel, Hamilton ; Gualano, Bruno ; Bonfa, Eloisa

• Document type: Journal article
• Source: JOURNAL OF PHYSICAL ACTIVITY & HEALTH; v. N/A, p. 4-pg., 2023-06-08.

Abstract

Aim: To investigate the association between physical activity and immunogenicity among SARS-CoV-2 seropositive patients with autoimmune rheumatic diseases prior to and following a 2-dose schedule of CoronaVac (Sinovac inactivated vaccine). Methods: This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial conducted in Sao Paulo, Brazil. In this substudy, only SARS-CoV-2 seropositive patients were included. Immunogenicity was assessed by seroconversion rates of total anti-SARS-CoV-2 S1/S2 immunoglobulin G (IgG), geometric mean titers of anti-S1/S2 IgG, frequency of positive neutralizing antibodies, and neutralizing activity before and after vaccination. Physical activity was assessed through a questionnaire. Model-based analyses were performed controlling for age (<60 or>_60 y), sex, body mass index (<25, 25-30, and >30 kg/m2), and use of prednisone, immunosuppressants, and biologics. Results: A total of 180 seropositive autoimmune rheumatic disease patients were included. There was no association between physical activity and immunogenicity before and after vaccination. Conclusions: This study suggests that the positive association between physical activity and greater antibody responses seen in immunocompromised individuals following vaccination is overridden by previous SARS-CoV-2 infection, and does not extend to natural immunity. (AU)

• FAPESP's process: 17/23688-9 - High-intensity intermittent training and beta-alanine supplementation: effects on carnosine metabolism in skeletal muscle and exercise performance and capacity
• Grantee: Rafael Pires da Silva
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/14820-6 - Healthy lifestyle promotion in patients with Systemic Lupus Erythematosus: effects on life quality and psychological aspects
• Grantee: Bruna Caruso Mazzolani
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 17/13552-2 - Reducing sedentary time in clinical populations: the take a stand for health study
• Grantee: Bruno Gualano
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/26937-4 - Studies on physical (in)activity in patients with rheumatoid arthritis: characterization, associations with disease and effects of breaking up sedentary time
• Grantee: Ana Jéssica Pinto
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 15/03756-4 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy
• Grantee: Eloisa Silva Dutra de Oliveira Bonfá
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/04877-8 - Impact of interleukin-6 receptor blockade on acute response to exercise on insulin sensitivity and muscle glucose uptake in patients with Rheumatoid Arthritis
• Grantee: Ítalo Ribeiro Lemes
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/14819-8 - Promotion of healthy lifestyle in patients with Systemic Lupus Erythematosus: assessment of safety, efficiency and feasibility of the study 'Vivendo bem com Lúpus' (Living well with Lupus)
• Grantee: Fabiana Infante Smaira
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 19/15231-4 - Promotion of healthy lifestyle in patients with Systemic Erythematosus Lupus: effects on cardiometabolic risks factors the randomized and controlled clinical trial living well with Lupus
• Grantee: Sofia Mendes Sieczkowska
• Support Opportunities: Scholarships in Brazil - Doctorate