Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise

Author(s)

Batitucci, Gabriela ; Abud, Gabriela Ferreira ; Ortiz, Gabriela Ueta ; Belisario, Lucas Fernandes ; Travieso, Sofia Germano ; Viliod, Marcela Coffacci de Lima ; Venturini, Ana Claudia Rossini ; de Freitas, Ellen Cristini

• Document type: Journal article
• Source: AGEING RESEARCH REVIEWS; v. 101, p. 16-pg., 2024-09-19.

Abstract

Enigmatic sarcopenic obesity is still a challenge for science and adds to the global public health burden. The progressive accumulation of body fat combined with a dysfunctional skeletal muscle structure and composition, oxidative stress, mitochondrial dysfunction, and anabolic resistance, among other aggravating factors, together represent the seriousness and complexity of treating the metabolic disorder of sarcobesity in aging. For this reason, further studies are needed that encourage the support of therapeutic management. It is along these lines that we direct the reader to therapeutic approaches that demonstrate important, but still obscure, outcomes in the physiological conditions of sarcobesity, such as the role of taurine in modulating inflammatory and antioxidant mechanisms in muscle and adipose tissue, as well as the management of gut microbiota, able to systemically re-establish the structure and function of the gut-muscle axis, in addition to the merits of physical exercise as an instrument to improve muscular health and lifestyle quality. (AU)

• FAPESP's process: 22/06638-6 - Metabolic and molecular responses under the effect of taurine supplementation with and without multicomponent training in elderly women with sarcopenic obesity using the metabolomics approach.
• Grantee: Gabriela Ferreira Abud
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 22/00221-6 - Taurine supplementation associated or not with physical exercise: effect on the browning of white adipose tissue in elderly women with Sarcopenic Obesity
• Grantee: Gabriela Ueta Ortiz
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 22/15078-4 - Taurine supplementation associated or not with multicomponent training: effect on white adipose tissue browning and metabolic and molecular responses using the metabolomics approach in elderly women with Sarcopenic Obesity
• Grantee: Ellen Cristini de Freitas
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/17947-7 - Effects of intermittent fasting and physical exercise on modulation of the gut microbiota, energy metabolism and inflammatory cytokines in Obesity
• Grantee: Gabriela Batitucci Miranda
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 24/01271-2 - Effects of high-intensity interval exercise with hypoxic recovery and taurine supplementation on metabolic and mitochondrial parameters in women with obesity
• Grantee: Marcela Coffacci de Lima Viliod
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/11820-5 - Nr1d1 function on the aging-associated Sarcopenia
• Grantee: Adelino Sanchez Ramos da Silva
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 23/01611-5 - Evaluation of the DNA methylation pattern in healthy, sarcopenic, obese and obese sarcopenic older adults: a cross-cross-cross study
• Grantee: Ellen Cristini de Freitas
• Support Opportunities: Regular Research Grants
• FAPESP's process: 23/09554-0 - Evaluation of the DNA methylation pattern in healthy, sarcopenic, obese and obese sarcopenic older adults: a cross-cross-cross study
• Grantee: Ana Claudia Rossini Venturini
• Support Opportunities: Scholarships in Brazil - Support Program for Fixating Young Doctors