Multi-User Equipment approved in grant 2017/25588-1: cromatógrafo Acquity UPLC I-Class

• Grant number: 19/00098-7
• Support Opportunities: Multi-user Equipment Program
• Start date: March 01, 2019
• End date: February 28, 2026
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Daniel Martins-de-Souza
• Grantee: Daniel Martins-de-Souza
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• City of the host institution: Campinas
• Associated research grant: 17/25588-1 - From the basic understanding to clinical biomarkers to schizophrenia: a neuroproteomics-centered multidisciplinary study, AP.TEM
• EMU web page: https://www.ib.unicamp.br/extensao/espectrometroUPLC
• Type of equipment: Caracterização de Materiais - Análises Químicas - Cromatografia líquida acoplada a espectrômetro de massa
• Manufacturer: Waters
• Model: SYNAPT G2-Si HDMS com nanoACQUITY UPLC

Abstract

This equipment will enable the establishment of a lipidomic platform for the study of brain diseases, in particular psychiatric disorders. This equipment will be combined with the mass spectrometer also funded by FAPESP (2014 / 10068-4). (AU)

Scientific publications

(30)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

VELASQUEZ, ERIKA; MARTINS-DE-SOUZA, DANIEL; VELASQUEZ, INGRID; ALVES CARNEIRO, GABRIEL REIS; SCHMITT, ANDREA; FALKAI, PETER; DOMONT, GILBERTO B.; NOGUEIRA, FABIO C. S.. Quantitative Subcellular Proteomics of the Orbitofrontal Cortex of Schizophrenia Patients. JOURNAL OF PROTEOME RESEARCH, v. 18, n. 12, SI, p. 4240-4253, DEC 2019. (17/25588-1, 19/00098-7)

RUBIO, MARCELO VENTURA; FANCHINI TERRASAN, CESAR RAFAEL; CONTESINI, FABIANO JARES; ZUBIETA, MARIANE PALUDETTI; GERHARDT, JAQUELINE ALINE; OLIVEIRA, LEANDRO CRISTANTE; DE SOUZA SCHMIDT GONCALVES, ANY ELISA; ALMEIDA, FAUSTO; SMITH, BRADLEY JOSEPH; MARTINS FERREIRA DE SOUZA, GUSTAVO HENRIQUE; et al. Redesigning N-glycosylation sites in a GH3 beta-xylosidase improves the enzymatic efficiency. BIOTECHNOLOGY FOR BIOFUELS, v. 12, n. 1, NOV 14 2019. (12/20549-4, 13/08293-7, 16/16306-0, 17/22669-0, 17/10083-1, 19/00098-7, 14/15403-6, 13/24988-5)

DIAS, THOMAZ LUSCHER; SCHUCH, VIVIANE; BALEEIRO BELTRAO-BRAGA, PATRICIA CRISTINA; MARTINS-DE-SOUZA, DANIEL; BRENTANI, HELENA PAULA; FRANCO, GLORIA REGINA; NAKAYA, HELDER IMOTO. Drug repositioning for psychiatric and neurological disorders through a network medicine approach. TRANSLATIONAL PSYCHIATRY, v. 10, n. 1, MAY 12 2020. (17/25588-1, 18/03673-0, 14/10068-4, 19/00098-7, 18/16748-8)

DE ALMEIDA, VALERIA; ALEXANDRINO, GUILHERME L.; AQUINO, ADRIANO; GOMES, ALEXANDRE F.; MURGU, MICHAEL; DOBROWOLNY, HENRIK; GUEST, PAUL C.; STEINER, JOHANN; MARTINS-DE-SOUZA, DANIEL. Changes in the blood plasma lipidome associated with effective or poor response to atypical antipsychotic treatments in schizophrenia patients. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 101, JUL 13 2020. (17/25588-1, 15/08201-0, 14/10068-4, 17/18242-1, 15/09159-8, 19/00098-7)

MARTINS-DE-SOUZA, DANIEL; GUEST, PAUL C.; REIS-DE-OLIVEIRA, GUILHERME; SCHMITT, ANDREA; FALKAI, PETER; TURCK, CHRISTOPH W.. An overview of the human brain myelin proteome and differences associated with schizophrenia. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v. 22, n. 4, JUL 2020. (19/00098-7, 18/01410-1, 17/25588-1)

COSTA, MARCELO N.; GOTO-SILVA, LIVIA; NASCIMENTO, JULIANA M.; DOMITH, IVAN; KARMIRIAN, KARINA; FEILDING, AMANDA; TRINDADE, PABLO; MARTINS-DE-SOUZA, DANIEL; K. REHEN, STEVENS. LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids. ACS OMEGA, v. 9, n. 34, p. 16-pg., 2024-08-16. (17/25588-1, 19/00098-7)

DE SOUZA, WILLIAM M.; FUMAGALLI, MARCILIO J.; DE LIMA, SHIRLENE T. S.; PARISE, PIERINA L.; CARVALHO, DEYSE C. M.; HERNANDEZ, CRISTIAN; DE JESUS, RONALDO; DELAFIORI, JEANY; CANDIDO, DARLAN S.; CARREGARI, VICTOR C.; et al. Pathophysiology of chikungunya virus infection associated with fatal outcomes. CELL HOST & MICROBE, v. 32, n. 4, p. 26-pg., 2024-04-10. (19/24251-9, 17/26908-0, 22/04420-3, 18/14389-0, 19/27333-6, 19/05155-9, 18/17176-8, 17/25588-1, 19/00098-7, 13/08293-7, 19/05718-3)

DE ALMEIDA, VALERIA; SEABRA, GABRIELA; REIS-DE-OLIVEIRA, GUILHERME; ZUCCOLI, GIULIANA S.; RUMIN, PRISCILA; FIORAMONTE, MARIANA; SMITH, BRADLEY J.; ZUARDI, ANTONIO W.; HALLAK, JAIME E. C.; CAMPOS, ALLINE C.; et al. Cannabinoids modulate proliferation, differentiation, and migration signaling pathways in oligodendrocytes. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v. 272, n. 7, p. 13-pg., 2022-05-27. (17/25588-1, 17/18242-1, 18/25818-0, 19/00098-7, 18/03673-0)

TRINDADE, PABLO; NASCIMENTO, JULIANA MINARDI; CASAS, BARBARA S.; MONTEVERDE, TOMAS; GASPAROTTO, JUCIANO; RIBEIRO, CAMILA TIEFENSEE; DEVALLE, SYLVIE; SAUMA, DANIELA; FONSECA MOREIRA, JOSE CLAUDIO; GELAIN, DANIEL PENS; et al. Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization. MOLECULAR PSYCHIATRY, v. N/A, p. 12-pg., 2022-10-24. (17/25588-1, 19/00098-7, 14/21035-0)

CARREGARI, VICTOR C.; REIS-DE-OLIVEIRA, GUILHERME; CRUNFLI, FERNANDA; SMITH, BRADLEY J.; DE SOUZA, GABRIELA FABIANO; MURARO, STEFANIE PRIMON; SAIA-CEREDA, VERONICA M.; VENDRAMINI, PEDRO H.; BALDASSO, PAULO A.; SILVA-COSTA, LICIA C.; et al. Diving into the proteomic atlas of SARS-CoV-2 infected cells. SCIENTIFIC REPORTS, v. 14, n. 1, p. 14-pg., 2024-03-28. (13/07607-8, 13/07559-3, 20/05601-6, 14/10068-4, 17/25588-1, 13/08216-2, 19/11457-8, 19/00098-7, 20/04919-2, 20/04860-8, 20/04746-0)

VELASQUEZ, ERIKA; MARTINS-DE-SOUZA, DANIEL; VELASQUEZ, INGRID; ALVES CARNEIRO, GABRIEL REIS; SCHMITT, ANDREA; FALKAI, PETER; DOMONT, GILBERTO B.; NOGUEIRA, FABIO C. S.. Quantitative Subcellular Proteomics of the Orbitofrontal Cortex of Schizophrenia Patients. JOURNAL OF PROTEOME RESEARCH, v. 18, n. 12, p. 14-pg., 2019-12-01. (17/25588-1, 19/00098-7)

SMITH, BRADLEY J.; GUEST, PAUL C.; MARTINS-DE-SOUZA, DANIEL. Maximizing Analytical Performance in Biomolecular Discovery with LC-MS: Focus on Psychiatric Disorders. ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, v. 17, p. 22-pg., 2024-01-01. (19/00098-7, 19/25957-2)

SMITH, BRADLEY J.; MARTINS-DE-SOUZA, DANIEL; SIMIONATO, AVC. Biological Applications for LC-MS-Based Proteomics. SEPARATION TECHNIQUES APPLIED TO OMICS SCIENCES: FROM PRINCIPLES TO RELEVANT APPLICATIONS, v. 1336, p. 13-pg., 2021-01-01. (14/10068-4, 16/07948-8, 19/05747-3, 19/00098-7, 17/25588-1)

FIORAMONTE, MARIANA; REIS-DE-OLIVEIRA, GUILHERME; BRANDAO-TELES, CAROLINE; MARTINS-DE-SOUZA, DANIEL. A glimpse on the architecture of hnRNP C1/C2 interaction network in cultured oligodendrocytes. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1869, n. 12, DEC 2021. (18/01410-1, 16/18715-4, 17/25588-1, 19/00098-7, 17/25055-3)

NASCIMENTO, JULIANA MINARDI; GOUVEA-JUNQUEIRA, DANIELLE; ZUCCOLI, GIULIANA S.; GOUVEIA PEDROSA, CAROLINA DA SILVA; BRANDAO-TELES, CAROLINE; CRUNFLI, FERNANDA; ANTUNES, ANDRE S. L. M.; CASSOLI, JULIANA S.; KARMIRIAN, KARINA; SALERNO, JOSE ALEXANDRE; et al. Zika Virus Strains and Dengue Virus Induce Distinct Proteomic Changes in Neural Stem Cells and Neurospheres. Molecular Neurobiology, v. N/A, p. 15-pg., 2022-06-22. (18/25439-9, 14/21035-0, 17/25055-3, 18/14666-4, 19/00098-7, 20/10282-7, 17/25588-1)

ORNELAS, ISIS M.; CINI, FELIPE A.; WIESSNER, ISABEL; MARCOS, ENCARNI; ARAUJO, DRAULIO B.; GOTO-SILVA, LIVIA; NASCIMENTO, JULIANA; SILVA, SERGIO R. B.; COSTA, MARCELO N.; FALCHI, MARCELO; et al. Nootropic effects of LSD: Behavioral, molecular and computational evidence. Experimental Neurology, v. 356, p. 14-pg., 2022-07-12. (14/10068-4, 17/25588-1, 13/07699-0, 19/00098-7)

SEABRA, GABRIELA; DE ALMEIDA, VALERIA; REIS-DE-OLIVEIRA, GUILHERME; CRUNFLI, FERNANDA; LEAO MARCELO ANTUNES, ANDRE SARAIVA; MARTINS-DE-SOUZA, DANIEL. Ubiquitin-proteasome system, lipid metabolism and DNA damage repair are triggered by antipsychotic medication in human oligodendrocytes: implications in schizophrenia. SCIENTIFIC REPORTS, v. 10, n. 1, JUL 28 2020. (19/22398-2, 17/25588-1, 14/10068-4, 17/18242-1, 19/03271-1, 19/00098-7, 18/03673-0)

FALVELLA, ANA CAROLINE BRAMBILLA; SMITH, BRADLEY JOSEPH; SILVA-COSTA, LICIA C.; VALENCA, ALINE G. F.; CRUNFLI, FERNANDA; ZUARDI, ANTONIO W.; HALLAK, JAIME E.; CRIPPA, JOSE A.; ALMEIDA, VALERIA DE; MARTINS-DE-SOUZA, DANIEL. Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. FRONTIERS IN MOLECULAR NEUROSCIENCE, v. 14, MAY 28 2021. (18/03422-7, 08/09009-2, 17/18242-1, 19/00098-7, 17/25588-1, 19/22398-2, 18/10362-0, 18/03450-0, 18/03673-0)

PINTO, LEONARDO DA SILVA; ALVES JUNIOR, RONALDO SILVA; PEREIRA LOPES, BRUNO RAFAEL; DA SILVA, GABRIEL SOARES; MENEZES, GABRIELA DE LIMA; MOREIRA, PEDRO; DE OLIVEIRA, JULIANA; DA SILVA, ROOSEVELT ALVES; LOUSA, DIANA; TOLEDO, KARINA ALVES. MPO interacts with hRSV particles, contributing to the virucidal effects of NETs against clinical and laboratory hRSV isolates. International Journal of Biological Macromolecules, v. 283, p. 7-pg., 2024-11-18. (21/05107-4, 18/09021-4, 19/00098-7, 22/14220-1)

ZUCCOLI, GIULIANA S.; REIS-DE-OLIVEIRA, GUILHERME; GARBES, BRUNA; FALKAI, PETER; SCHMITT, ANDREA; NAKAYA, I, HELDER; MARTINS-DE-SOUZA, DANIEL. Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, MAR 2021. (17/25588-1, 19/00098-7, 18/01410-1, 13/08216-2, 18/14666-4, 12/19278-6, 17/50137-3)

JOSEPH SMITH, BRADLEY; BRANDAO-TELES, CAROLINE; ZUCCOLI, GIULIANA S.; REIS-DE-OLIVEIRA, GUILHERME; FIORAMONTE, MARIANA; SAIA-CEREDA, VERONICA M.; MARTINS-DE-SOUZA, DANIEL. Protein Succinylation and Malonylation as Potential Biomarkers in Schizophrenia. JOURNAL OF PERSONALIZED MEDICINE, v. 12, n. 9, p. 15-pg., 2022-09-01. (14/10068-4, 16/07948-8, 17/25055-3, 15/23049-0, 18/01410-1, 18/14666-4, 19/05747-3, 16/07332-7, 13/08711-3, 19/00098-7, 17/25588-1)

SILVA-COSTA, LICIA C.; SMITH, BRADLEY J.; CARREGARI, VICTOR CORASOLLA; SOUZA, GUSTAVO H. M. F.; VIEIRA, ERICA M.; MENDES-SILVA, ANA PAULA; ALMEIDA, VALERIA DE; CARVALHO, BENILTON S.; DINIZ, BRENO S.; MARTINS-DE-SOUZA, DANIEL. Plasma proteomic signature of major depressive episode in the elderly. JOURNAL OF PROTEOMICS, v. 269, p. 9-pg., 2022-10-30. (14/10068-4, 19/05155-9, 17/18242-1, 20/09165-6, 16/07948-8, 19/05747-3, 17/25588-1, 19/00098-7, 18/03422-7)

SACCON, TATIANA DANDOLINI; MOUSOVICH-NETO, FELIPPE; LUDWIG, RAISSA GUIMARAES; CARREGARI, VICTOR CORASOLLA; DOS ANJOS SOUZA, ANA BEATRIZ; DOS PASSOS, AMANDA STEPHANE CRUZ; MARTINI, MATHEUS CAVALHEIRO; BARBOSA, PRISCILLA PASCHOAL; DE SOUZA, GABRIELA FABIANO; MURARO, STEFANIE PRIMON; et al. SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner. NATURE COMMUNICATIONS, v. 13, n. 1, p. 15-pg., 2022-09-29. (20/08716-9, 20/04558-0, 19/05155-9, 21/10373-5, 13/07607-8, 20/04919-2, 20/04746-0, 17/01184-9, 17/23920-9, 16/24163-4, 16/00194-8, 18/21635-8, 19/00098-7, 20/05040-4, 17/08264-8, 20/04579-7, 19/26119-0, 19/04726-2, 20/04583-4, 20/15959-5)

CODO, ANA CAMPOS; DAVANZO, GUSTAVO GASTAO; MONTEIRO, LAUAR DE BRITO; DE SOUZA, GABRIELA FABIANO; MURARO, STEFANIE PRIMON; VIRGILIO-DA-SILVA, JOAO VICTOR; PRODONOFF, JULIANA SILVEIRA; CARREGARI, VICTOR CORASOLLA; OLIVEIRA DE BIAGI JUNIOR, CARLOS ALBERTO; CRUNFLI, FERNANDA; et al. Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1 alpha/Glycolysis-Dependent Axis. Cell Metabolism, v. 32, n. 3, p. 15-pg., 2020-09-01. (19/00098-7, 20/04558-0, 20/04522-5, 19/06372-3, 16/18031-8, 15/15626-8, 16/23328-0, 17/01184-9, 20/04919-2, 20/04583-4, 20/04579-7, 18/22505-0, 20/04746-0)

BOLDARINE, VALTER T.; PEDROSO, AMANDA P.; BRANDAO-TELES, CAROLINE; LOTURCO, EDSON G.; NASCIMENTO, CLAUDIA M. O.; OYAMA, LILA M.; BUENO, ALLAIN A.; MARTINS-DE-SOUZA, DANIEL; RIBEIRO, ELIANE B.. Ovariectomy modifies lipid metabolism of retroperitoneal white fat in rats: a proteomic approach. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 319, n. 2, p. 11-pg., 2020-08-01. (12/03172-4, 19/00098-7, 14/10068-4)

BRUNETTI, NATALIA S.; DAVANZO, GUSTAVO G.; DE MORAES, DIOGO; FERRARI, ALLAN J. R.; SOUZA, GABRIELA F.; MURARO, STEFANIE PRIMON; KNITTEL, THIAGO L.; BOLDRINI, VINICIUS O.; MONTEIRO, LAUAR B.; VIRGILIO-DA-SILVA, JOO VICTOR; et al. SARS-CoV-2 uses CD4 to infect T helper lymphocytes. eLIFE, v. 12, p. 26-pg., 2023-07-31. (20/04558-0, 15/15626-8, 19/06459-1, 19/04726-2, 19/16116-4, 19/05155-9, 19/13552-8, 16/18031-8, 19/00098-7, 20/04583-4, 16/00194-8, 21/08354-2, 19/17007-4, 19/22398-2, 17/01184-9, 19/14465-1, 20/04579-7, 13/08293-7, 18/14933-2, 17/23920-9, 19/06372-3, 16/24163-4, 16/23328-0, 20/04919-2, 20/04746-0)

REIS-DE-OLIVEIRA, G.; ZUCCOLI, G. S.; FIORAMONTE, M.; SCHIMITT, A.; FALKAI, P.; ALMEIDA, V; MARTINS-DE-SOUZA, D.. Digging deeper in the proteome of different regions from schizophrenia brains. JOURNAL OF PROTEOMICS, v. 223, JUL 15 2020. (17/25588-1, 18/14666-4, 18/03673-0, 17/18242-1, 19/00098-7, 16/18715-4, 18/01410-1, 14/10068-4)

ZUCCOLI, GIULIANA S.; REIS-DE-OLIVEIRA, GUILHERME; GARBES, BRUNA; FALKAI, PETER; SCHMITT, ANDREA; NAKAYA, I, HELDER; MARTINS-DE-SOUZA, DANIEL. Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v. 271, n. 8, p. 1579-1586, DEC 2021. (18/01410-1, 17/25588-1, 13/08216-2, 19/00098-7, 12/19278-6, 17/50137-3, 18/14666-4)

NASCIMENTO, JULIANA MINARDI; SAIA-CEREDA, VERONICA M.; ZUCCOLI, GIULIANA S.; REIS-DE-OLIVEIRA, GUILHERME; CARREGARI, VICTOR CORASOLLA; SMITH, BRADLEY J.; REHEN, STEVENS K.; MARTINS-DE-SOUZA, DANIEL. Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains. CELL AND BIOSCIENCE, v. 12, n. 1, p. 16-pg., 2022-12-01. (17/25588-1, 19/25957-2, 14/21035-0, 19/05747-3, 18/14666-4, 19/00098-7, 18/01410-1, 16/07332-7)

KOCAK, GAMZE; DIMAS, MYLLA M.; SILVA, LUIZ F. S. E.; SILVA-AMARAL, DANYELLE; SUN, CONGXIN; CRUDDAS, SOPHIE; BARRETT, TIMOTHY; MARTINS-DE-SOUZA, DANIEL; CUNHA-NETO, EDECIO; BROCARDO, PATRICIA S.; et al. Autophagy-NAD⁺ axis: emerging insights into neuronal homeostasis and neurodegenerative diseases. FRONTIERS IN MOLECULAR BIOSCIENCES, v. 12, p. 17-pg., 2025-11-26. (22/00758-0, 23/00841-7, 24/03869-2, 19/00098-7, 17/25588-1, 24/22132-0)