Mechanisms involved in the pathophysiology of rheumatoid arthritis, pain and sepsis

• Grant number: 11/19670-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: May 01, 2012
• End date: June 30, 2017
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Fernando de Queiroz Cunha
• Grantee: Fernando de Queiroz Cunha
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto
• Principal investigators: José Carlos Farias Alves Filho ; Paulo Louzada Junior ; Thiago Mattar Cunha
• Principal investigators: Sérgio Henrique Ferreira
• Associated research grant(s): 13/09434-3 - Immunopharmacological salivary modulators from hematophagous arthropods, AV.EXT
• Associated scholarship(s): 15/22182-9 - The role of the Transient Receptor Potencial vanilloid-1 in the induction and maintenance of herpetic- and post-herpetic neuralgia., BP.IC; 14/09008-7 - The role of pattern recognition receptors like toll-like receptors 4 in the induction and maintenance of herpetic and post-herpetic neuralgia, BP.PD; 13/15316-3 - Investigation of the protective role of interleukin 27 (IL-27) on the genesis and maintenance of neuropathic pain, BP.DR; + associated scholarships 13/04942-0 - Molecular mechanisms involved in the enhancement of Th17 response by aryl hydrocarbon receptor (AHR) - correlation with rheumatoid arthritis, BP.DR; 13/07968-0 - The role of indoleamine 2,3-dioxygenase in supraspinal structures in the induction and maintenance of neuropathic pain, BP.MS; 13/03758-1 - Role of D6 receptor in development and maintenance of chronic neuropathic pain, BP.DR; 12/04132-6 - Role of D6 receptor in the inflammatory response development during sepsis, BP.DR; 12/04076-9 - Role of the aryl hydrocarbon receptor (AhR) in the pathogenesis of sepsis, BP.PD; 11/13097-7 - Role of indoleamine 2,3-dioxygenase in the induction and maintenance of neuropathic pain, BP.PD - associated scholarships

Abstract

For the past 25 years, our group has been studying the physiopathological mechanisms involved in the inflammatory process. In order to continue doing so, in this project we seek to do translational research regarding inflammatory diseases, mainly rheumatoid arthritis, chronic pain and sepsis. All three topics will be investigated in an integrated stand: 1) mechanisms involved in recognizing the triggering agents, focusing in pattern recognition receptors (TLRs and NLRs), their endogenous ligands and the activation of recognition cells (dendritic cells, glial cell, mastocytes, synoviocytes); 2) effector mechanisms, especially regarding cytokines and chemokines roles and their receptors, and effector cells (neutrophils, lymphocytes and macrophages); intracellular signaling, including intracellular receptors (AhR, PPARgama, LXR) and transcription factors (NFkB, AP-1, CREB); and finally 4) immune response modulators, focusing in adenosine, Indoleamine 2,3-dioxygenase, eicosanoids and co-stimulatory molecule CD28. Developing this project will allow the identification of new common biological target to most of the three aforementioned topics, leading to the development of new biological markers and treatment schemes for those diseases. (AU)

Scientific publications

(82)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

COLON, DAVID F.; WANDERLEY, CARLOS W.; FRANCHIN, MARCELO; SILVA, CAMILA M.; HIROKI, CARLOS H.; CASTANHEIRA, FERNANDA V. S.; DONATE, PAULA B.; LOPES, ALEXANDRE H.; VOLPON, LEILA C.; KAVAGUTI, SILVIA K.; et al. Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis. CRITICAL CARE, v. 23, APR 8 2019. (13/08216-2, 11/19670-0)

LOURENCO-GONZALEZ, YURI; FATTORI, VICTOR; DOMICIANO, TALITA P.; ROSSANEIS, ANA C.; BORGHI, SERGIO M.; ZANINELLI, TIAGO H.; BERNARDY, CATIA C. F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; et al. Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation. Mediators of Inflammation, 2019. (13/08216-2, 11/19670-0)

SONEGO, FABIANE; CASTANHEIRA, FERNANDA V. S.; CZAIKOSKI, PAULA G.; KANASHIRO, ALEXANDRE; SOUTO, FABRICIO O.; FRANCA, RAFAEL O.; NASCIMENTO, DANIELE C.; FREITAS, ANDRESSA; SPILLER, FERNANDO; CUNHA, LARISSA D.; et al. MyD88-, but Not Nod1- and/or Nod2-Deficient Mice, Show Increased Susceptibility to Polymicrobial Sepsis due to Impaired Local Inflammatory Response. PLoS One, v. 9, n. 8, AUG 1 2014. (08/11593-4, 11/19670-0)

TAMASHIRO, LETICIA FALEIROS; OLIVEIRA, RENE D. R.; OLIVEIRA, RODRIGO; COMINI FROTA, ELIZABETH REGINA; DONADI, EDUARDO ANTONIO; DEL-BEN, CRISTINA MARTA; TEIXEIRA, ANTONIO LUCIO; LOUZADA-JUNIOR, PAULO. Participation of the neutrophin brain-derived neurotrophic factor in neuropsychiatric systemic lupus erythematosus. RHEUMATOLOGY, v. 53, n. 12, p. 2182-2190, DEC 2014. (13/08216-2, 11/19670-0)

PARRA, ROGERIO S.; LOPES, ALEXANDRE H.; CARREIRA, ELEONORA U.; FEITOSA, MARLEY R.; CUNHA, FERNANDO Q.; GARCIA, SERGIO B.; CUNHA, THIAGO M.; DA ROCHA, JOSE J. R.; FERES, OMAR. Hyperbaric oxygen therapy ameliorates TNBS-induced acute distal colitis in rats. MEDICAL GAS RESEARCH, v. 5, APR 16 2015. (11/19670-0)

SOUZA, GUILHERME R.; CUNHA, THIAGO M.; SILVA, RANGE L.; LOTUFO, CELINA M.; VERRI, JR., WALDICEU A.; FUNEZ, MANI I.; VILLARREAL, CHRISTIANE F.; TALBOT, JHIMMY; SOUSA, LIRLANDIA P.; PARADA, CARLOS A.; et al. Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception. Pharmacology Biochemistry and Behavior, v. 134, p. 49-56, JUL 2015. (13/08216-2, 11/19670-0)

TALBOT, JHIMMY; BIANCHINI, FRANCINE J.; NASCIMENTO, DANILELE C.; OLIVEIRA, RENE D. R.; SOUTO, FABRICIO O.; PINTO, LARISSA G.; PERES, RAPHAEL S.; SILVA, JAQUELINE R.; ALMEIDA, SERGIO C. L.; LOUZADA-JUNIOR, PAULO; et al. CCR2 Expression in Neutrophils Plays a Critical Role in Their Migration Into the Joints in Rheumatoid Arthritis. ARTHRITIS & RHEUMATOLOGY, v. 67, n. 7, p. 1751-1759, JUL 2015. (13/08216-2, 11/19670-0)

SANT'ANNA, MORENA B.; KUSUDA, RICARDO; BOZZO, TIAGO A.; BASSI, GABRIEL S.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; FERREIRA, SERGIO H.; SOUZA, GUILHERME R.; CUNHA, THIAGO M.. Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. SCIENTIFIC REPORTS, v. 6, MAY 27 2016. (13/08216-2, 11/19670-0)

BERTOZZI, MARIANA M.; ROSSANEIS, ANA C.; FATTORI, VICTOR; LONGHI-BALBINOT, DANIELA T.; FREITAS, ANDRESSA; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Diosmin reduces chronic constriction injury-induced neuropathic pain in mice. Chemico-Biological Interactions, v. 273, p. 180-189, AUG 1 2017. (13/08216-2, 11/19670-0)

ZUCOLOTO, AMANDA Z.; MANCHOPE, MARILIA F.; STAURENGO-FERRARI, LARRISA; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; ANTUNES, MAISA M.; MENEZES, GUSTAVO B.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-kappa B activation and cytokine production without antioxidant effects. Inflammation Research, v. 66, n. 7, p. 591-602, JUL 2017. (13/08216-2, 11/19670-0)

PINTO, LARISSA G.; TALBOT, JHIMMY; PERES, RAPHAEL S.; FRANCA, RAFAEL F.; FERREIRA, SERGIO H.; RYFFEL, BERNHARD; AVES-FILHO, JOSE CARLOS F.; FIGUEIREDO, FLORENCIO; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1 beta production. ARTHRITIS RESEARCH & THERAPY, v. 17, SEP 2 2015. (13/08216-2, 11/19670-0)

VERAS, FLAVIO P.; PERES, RAPHAEL S.; SARAIVA, ANDRE L. L.; PINTO, LARISSA G.; LOUZADA-JUNIOR, PAULO; CUNHA, THIAGO M.; PASCHOAL, JONAS A. R.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.. Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway. SCIENTIFIC REPORTS, v. 5, OCT 19 2015. (13/08216-2, 09/54014-7, 11/19670-0)

QUADROS, ANDREZA U.; PINTO, LARISSA G.; FONSECA, MIRIAM M.; KUSUDA, RICARDO; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.. Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice. SCIENTIFIC REPORTS, v. 5, OCT 29 2015. (13/08216-2, 09/54014-7, 11/19670-0)

GUIMARAESI, RAFAELA M.; DAVOLI-FERREIRA, MARCELA; FONSECA, MIRIAM M.; DAMASCENO, LUIS EDUARDO A.; SANTA-CECILIA, V, FLAVIA; KUSUDA, RICARDO; MENEZES, GUSTAVO B.; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.. Frontline Science: Blood-circulating leukocytes fail to infiltrate the spinal cord parenchyma after spared nerve injury. Journal of Leukocyte Biology, v. 106, n. 3, SI, p. 541-551, SEP 2019. (13/08216-2, 11/19670-0)

RUIZ-MIYAZAWA, KENJI W.; STAURENGO-FERRARI, LARISSA; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZANINELLI, TIAGO H.; BADARO-GARCIA, STEPHANIE; BORGHI, SERGIO M.; ANDRADE, KETLEM C.; CLEMENTE-NAPIMOGA, JULIANA T.; ALVES-FILHO, JOSE C.; et al. 15d-PGJ(2)-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice. SCIENTIFIC REPORTS, v. 8, SEP 18 2018. (13/08216-2, 10/15014-9, 11/19670-0)

STAURENGO-FERRARI, LARISSA; RUIZ-MIYAZAWA, KENJI W.; PINHO-RIBEIRO, FELIPE A.; FATTORI, VICTOR; ZANINELLI, TIAGO H.; BADARO-GARCIA, STEPHANIE; BORGHI, SERGIO M.; CARVALHO, THACYANA T.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; et al. Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice. FRONTIERS IN PHARMACOLOGY, v. 9, OCT 2 2018. (13/08216-2, 11/19670-0)

FATTORI, VICTOR; ZARPELON, ANA C.; STAURENGO-FERRARI, LARISSA; BORGHI, SERGIO M.; ZANINELII, TIAGO H.; DA COSTA, FERNANDO B.; AIVES, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; et al. Budlein A, a Sesquiterpene Lactone From Viguiera robusta, Alleviates Pain and Inflammation in a Model o Acute Gout Arthritis in Mice. FRONTIERS IN PHARMACOLOGY, v. 9, SEP 25 2018. (13/08216-2, 11/19670-0)

LOPES, ALEXANDRE H.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIANCHINI, GIANLUCA; SILVA, RANGEL L.; ZAPERLON, ANA C.; VERRI, JR., WALDICEU A.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; TEIXEIRA, MAURO M.; et al. DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain. PHARMACOLOGICAL RESEARCH, v. 103, p. 69-79, JAN 2016. (13/08216-2, 11/19670-0)

RUIZ-MIYAZAWA, KENJI W.; BORGHI, SERGIO M.; PINHO-RIBEIRO, FELIPE A.; STAURENGO-FERRARI, LARISSA; FATTORI, VICTOR; FERNANDES, GLAURA S. A.; CASELLA, ANTONIO M.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; et al. The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NF kappa B and macrophage release of IL-1 beta. Journal of Functional Foods, v. 48, p. 106-116, SEP 2018. (13/08216-2, 11/19670-0, 10/15014-9)

FERREIRA, RAPHAEL G.; RODRIGUES, LILIAN C.; NASCIMENTO, DANIELE C.; KANASHIRO, ALEXANDRE; MELO, PAULO H.; BORGES, VANESSA F.; GOZZI, ALINE; PRADO, DOUGLAS DA SILVA; BORGES, MARCOS C.; RAMALHO, FERNANDO S.; et al. Galectin-3 aggravates experimental polymicrobial sepsis by impairing neutrophil recruitment to the infectious focus. Journal of Infection, v. 77, n. 5, p. 391-397, NOV 2018. (13/08216-2, 11/19670-0)

SONEGO, FABIANE; CASTANHEIRA, FERNANDA V. S.; HORTA, CATARINA V.; KANASHIRO, ALEXANDRE; CZAIKOSKI, PAULA G.; ZAMBONI, DARIO S.; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO Q.. The host control of a clinical isolate strain of P-aeruginosa infection is independent of Nod-1 but depends on MyD88. Inflammation Research, v. 67, n. 5, p. 435-443, MAY 2018. (08/11593-4, 11/19670-0)

FONSECA, MIRIAM D.; CUNHA, FERNANDO Q.; KASHFI, KHOSROW; CUNHA, THIAGO M.. NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain. PHARMACOLOGY RESEARCH & PERSPECTIVES, v. 3, n. 3, JUN 2015. (13/08216-2, 11/19670-0)

NASCIMENTO, DANIELE C.; MELO, PAULO H.; PINEROS, ANNIE R.; FERREIRA, RAPHAEL G.; COLON, DAVID F.; DONATE, PAULA B.; CASTANHEIRA, FERNANDA V.; GOZZI, ALINE; CZAIKOSKI, PAULA G.; NIEDBALA, WANDA; et al. IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population. NATURE COMMUNICATIONS, v. 8, APR 4 2017. (13/08216-2, 11/19670-0)

KANASHIRO, ALEXANDRE; SONEGO, FABIANE; FERREIRA, RAPHAEL G.; CASTANHEIRA, FERNANDA V. S.; LEITE, CAIO A.; BORGES, VANESSA F.; NASCIMENTO, DANIELE C.; COLON, DAVID F.; ALVES-FILHO, JOSE CARLOS; ULLOA, LUIS; et al. Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis. PHARMACOLOGICAL RESEARCH, v. 117, p. 1-8, MAR 2017. (13/08216-2, 12/04237-2, 11/19670-0, 11/20343-4)

FATTORI, VICTOR; SERAFIM, KARLA G. G.; ZARPELON, ANA C.; BORGHI, SERGIO M.; PINHO-RIBEIRO, FELIPE A.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; CASAGRANDE, RUBIA; VERRI, JR., WALDICEU A.. Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice. Journal of Drug Targeting, v. 25, n. 3, p. 264-274, 2017. (13/08216-2, 11/19670-0)

DAVOLI-FERREIRA, MARCELA; DE LIMA, KALIL A.; FONSECA, MIRIAM M.; GUIMARAES, RAFAELA M.; GOMES, I, FRANCISCO; CAVALLINI, MARIA C.; QUADROS, ANDREZA U.; KUSUDA, RICARDO; CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C.; et al. Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury. Pain, v. 161, n. 8, p. 1730-1743, AUG 2020. (13/08216-2, 11/19670-0)

PINTO, LARISSA G.; SOUZA, GUILHERME R.; KUSUDA, RICARDO; LOPES, ALEXANDRE H.; SANT'ANNA, MORENA B.; CUNHA, FERNANDO Q.; FERREIRA, SERGIO H.; CUNHA, THIAGO M.. Non-Peptidergic Nociceptive Neurons Are Essential for Mechanical Inflammatory Hypersensitivity in Mice. Molecular Neurobiology, v. 56, n. 8, p. 5715-5728, AUG 2019. (13/08216-2, 10/04043-8, 11/19670-0)

LOURENCO-GONZALEZ, YURI; FATTORI, VICTOR; DOMICIANO, TALITA P.; ROSSANEIS, ANA C.; BORGHI, SERGIO M.; ZANINELLI, TIAGO H.; BERNARDY, CATIA C. F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; et al. Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation. Mediators of Inflammation, v. 2019, p. 14-pg., 2019-01-01. (13/08216-2, 11/19670-0)

PINTO, LARISSA G.; TALBOT, JHIMMY; PERES, RAPHAEL S.; FRANCA, RAFAEL F.; FERREIRA, SERGIO H.; RYFFEL, BERNHARD; AVES-FILHO, JOSE CARLOS F.; FIGUEIREDO, FLORENCIO; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production. ARTHRITIS RESEARCH & THERAPY, v. 17, p. 13-pg., 2015-09-02. (13/08216-2, 11/19670-0)

SISTI, FLAVIA; WANG, SOUJUAN; BRANDT, STEPHANIE L.; GLOSSON-BYERS, NICOLE; MAYO, LINDSEY D.; SON, YOUNG MIN; STURGEON, SARAH; FILGUEIRAS, LUCIANO; JANCAR, SONIA; WONG, HECTOR; et al. Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis. SCIENCE SIGNALING, v. 11, n. 528, p. 14-pg., 2018-05-01. (13/08216-2, 11/19670-0)

PERES, RAPHAEL SANCHES; LIEW, FOO Y.; TALBOT, JHIMMY; CARREGARO, VANESSA; OLIVEIRA, RENE D.; ALMEIDA, SERGIO L.; FRANCA, RAFAEL F. O.; DONATE, PAULA B.; PINTO, LARISSA G.; FERREIRA, FLAVIA I. S.; et al. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 112, n. 8, p. 6-pg., 2015-02-24. (13/08216-2, 11/19670-0)

MORICONI, ALESSIO; CUNHA, THIAGO M.; SOUZA, GUILHERME R.; LOPES, ALEXANDRE H.; CUNHA, FERNANDO Q.; CARNEIRO, VICTOR L.; PINTO, LARISSA G.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIZZARRI, CINZIA; et al. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 111, n. 47, p. 6-pg., 2014-11-25. (13/08216-2, 11/19670-0)

PERES, RAPHAEL SANCHES; LIEW, FOO Y.; TALBOT, JHIMMY; CARREGARO, VANESSA; OLIVEIRA, RENE D.; ALMEIDA, SERGIO L.; FRANCA, RAFAEL F. O.; DONATE, PAULA B.; PINTO, LARISSA G.; FERREIRA, FLAVIA I. S.; et al. Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America, v. 112, n. 8, p. 2509-2514, FEB 24 2015. (13/08216-2, 11/19670-0)

MORICONI, ALESSIO; CUNHA, THIAGO M.; SOUZA, GUILHERME R.; LOPES, ALEXANDRE H.; CUNHA, FERNANDO Q.; CARNEIRO, VICTOR L.; PINTO, LARISSA G.; BRANDOLINI, LAURA; ARAMINI, ANDREA; BIZZARRI, CINZIA; et al. Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief. Proceedings of the National Academy of Sciences of the United States of America, v. 111, n. 47, p. 16937-16942, NOV 25 2014. (13/08216-2, 11/19670-0)

SISTI, FLAVIA; WANG, SOUJUAN; BRANDT, STEPHANIE L.; GLOSSON-BYERS, NICOLE; MAYO, LINDSEY D.; SON, YOUNG MIN; STURGEON, SARAH; FILGUEIRAS, LUCIANO; JANCAR, SONIA; WONG, HECTOR; et al. Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis. Science Signaling, v. 11, n. 528, MAY 1 2018. (13/08216-2, 11/19670-0)

KANASHIRO, ALEXANDRE; HIROKI, CARLOS HIROJI; DA FONSECA, DENISE MORAIS; BIRBRAIR, ALEXANDER; FERREIRA, RAPHAEL GOMES; BASSI, GABRIEL SHIMIZU; FONSECA, MIRIAN D.; KUSUDA, RICARDO; MARTELOSSI CEBINELLI, GUILHERME CESAR; DA SILVA, KATIUSSIA PINHO; et al. The role of neutrophils in neuro-immune modulation. PHARMACOLOGICAL RESEARCH, v. 151, JAN 2020. (16/08385-7, 13/08216-2, 11/20343-4, 11/19670-0, 12/04237-2)

MAGANIN, ALEXANDRE G.; SOUZA, GUILHERME R.; FONSECA, MIRIAM D.; LOPES, ALEXANDRE H.; GUIMARAES, RAFAELA M.; DAGOSTIN, ANDRE; CECILIO, NERRY T.; MENDES, ATLANTE S.; GONCALVES, WILLIAM A.; SILVA, CONCEICAO E. A.; et al. Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice. Journal of Clinical Investigation, v. 132, n. 23, p. 17-pg., 2022-12-01. (13/08216-2, 11/19670-0)

ZARPELON, ANA C.; RODRIGUES, FRANCIELLE C.; LOPES, ALEXANDRE H.; SOUZA, GUILHERME R.; CARVALHO, THACYANA T.; PINTO, LARISSA G.; XU, DAMO; FERREIRA, SERGIO H.; ALVES-FILHO, JOSE C.; MCINNES, IAIN B.; et al. Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain. FASEB JOURNAL, v. 30, n. 1, p. 54-65, JAN 2016. (13/08216-2, 11/19670-0)

SANTA-CECILIA, V, FLAVIA; FERREIRA, DAVID W.; GUIMARAES, RAFAELA M.; CECILIO, NERRY T.; FONSECA, MIRIAM M.; LOPES, ALEXANDRE H.; DAVOLI-FERREIRA, MARCELA; KUSUDA, RICARDO; SOUZA, GUILHERME R.; NACHBUR, UELI; et al. The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development. Pain, v. 160, n. 1, p. 102-116, JAN 2019. (13/08216-2, 11/19670-0)

SANTA-CECILIA, FLAVIA V.; SOCIAS, BENJAMIN; OUIDJA, MOHAND O.; SEPULVEDA-DIAZ, JULIA E.; ACUNA, LEONARDO; SILVA, RANGEL L.; MICHEL, PATRICK P.; DEL-BEL, ELAINE; CUNHA, THIAGO M.; RAISMAN-VOZARI, RITA. Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways. NEUROTOXICITY RESEARCH, v. 29, n. 4, p. 447-459, MAY 2016. (13/08216-2, 11/19670-0)

FATTORI, VICTOR; HOHMANN, MIRIAM S. N.; ROSSANEIS, ANA C.; MANCHOPE, MARILIA F.; ALVES-FILHO, JOSE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; VERRI, JR., WALDICEU A.. Targeting IL-33/ST2 signaling: regulation of immune function and analgesia. EXPERT OPINION ON THERAPEUTIC TARGETS, v. 21, n. 12, p. 1141-1152, 2017. (13/08216-2, 11/19670-0)

TALBOT, JHIMMY; PERES, RAPHAEL S.; PINTO, LARISSA G.; OLIVEIRA, RENE D. R.; LIMA, KALIL A.; DONATE, PAULA B.; SILVA, JAQUELINE R.; RYFFEL, BERNARD; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; et al. Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells. ARTHRITIS RESEARCH & THERAPY, v. 20, JUN 8 2018. (13/08216-2, 11/19670-0)

BASSI, GABRIEL S.; MALVAR, DAVID DO C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; KANASHIRO, ALEXANDRE. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 389, n. 8, p. 851-861, AUG 2016. (13/08216-2, 12/04237-2, 11/19670-0, 11/20343-4)

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P. MEDEIROS; I.R. DOS SANTOS; A.C. MEDEIROS; J.A. DA SILVA; S.H. FERREIRA; R.L. DE FREITAS; N.C. COIMBRA. Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury. Brazilian Journal of Medical and Biological Research, v. 53, n. 5, 2020-04-27. (12/25167-2, 13/08216-2, 13/12916-0, 17/13560-5, 14/11869-0, 09/17258-5, 14/07902-2, 11/19670-0)

CECILIO, NERRY T.; SOUZA, GUILHERME R.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; CUNHA, THIAGO M.. The PI3K gamma/AKT signaling pathway mediates peripheral antinociceptive action of dipyrone. FUNDAMENTAL & CLINICAL PHARMACOLOGY, v. 35, n. 2, p. 364-370, APR 2021. (13/08216-2, 11/19670-0)

Filed patent(s) as a result of this research project