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Identification of phenolic compounds and protective action of Rosmarinus officinallis supplementation on oxidative stress in rats submitted to myocardial infarction

Grant number: 12/23759-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): July 08, 2013
Effective date (End): July 07, 2014
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal researcher:Sergio Alberto Rupp de Paiva
Grantee:Bruna Paola Murino Rafacho
Supervisor abroad: Xiang-Dong Wang
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Research place: Tufts University, United States  
Associated to the scholarship:11/08956-0 - Influence of diet rosemary supplementation (Rosmarinus officinalis L.) on cardiac remodeling in rats subjected to acute myocardial infarction, BP.DR


An increased oxidative status is described after myocardial infarction. On the other hand, many beneficial effects have been attributed to constituents of plant foods, especially antioxidants. Rosemary is one of the most widely used herbs, known for its antioxidant effect. To support its use, it is of great relevance to characterize its compounds and its antioxidant actions. Objectives: identify phenolic compounds present in the rosemary extract used for supplementation in the main project and to determine the antioxidant status after rosemary supplementation in circulation as well as target tissue, cardiac tissue. Methods: rosemary extract produced in Brazil will be tested for antioxidant activity of fat and water soluble components and characterization of phenolic compounds using LC/UV/ESI-MS/MS analysis. Serum and heart tissue collected from animals used on the main project will be analyzed for protein carbonyl determination and total antioxidant performance. Values of the comparison between heart and serum analysis will be presented as mean ± SEM and comparisons will be made by two-way ANOVA test, with significance level of 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PAOLA MURINO RAFACHO, BRUNA; STICE, CAMILLA; LIU, CHUN; GREENBERG, ANDREW; AUSMAN, LYNNE; WANG, XIANG-DONG. Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice. HEPATOBILIARY SURGERY AND NUTRITION, v. 4, n. 2, 1, p. 124-134, . (12/23759-0)

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