- Research Grants
|Support type:||Scholarships in Brazil - Post-Doctorate|
|Effective date (Start):||March 01, 2014|
|Effective date (End):||November 30, 2016|
|Field of knowledge:||Biological Sciences - Parasitology - Protozoology of Parasites|
|Principal Investigator:||Adriana Karaoglanovic Carmona|
|Home Institution:||Instituto Nacional de Farmacologia (INFAR). Universidade Federal de São Paulo (UNIFESP). São Paulo , SP, Brazil|
Calcium as a second-messenger is essential for Plasmodium falciparum. Many aspects of intracellular signaling are unknown in the parasite, however some of the calcium effectors, as calmodulin, are annotated in the genome of Plasmodium. Calmodulin is an enzyme present in all eukaryotes and may be responsible for the activation of kinases, ionic channels and regulation of calcium homeostasis. The in silico prediction of the domains which bind calmodulin is seldom precise, due to the variability of these regions. The objectives of the project are to identify enzymes activated by calmodulin in Plasmodium. We will characterize the participation of calmodulin in the calcium homeostasis and proteolitic activity of the parasite, as well as the role of calmodulin in the generation of bioactive peptides that act as extracellular signals for the host.