Evaluation of aerobic capacity, quality of life, muscle strength and function in patients with immune-mediated necrotizing myopathy

• Grant number: 17/06794-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2017
• End date: April 30, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Samuel Katsuyuki Shinjo
• Grantee: Letícia Alves Perin
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Immune-mediated necrotizing myopathy (IMNM) is a rare systemic idiopathic inflammatory myopathy associated with high functional disability. It is characterized by an acute/subacute condition of skeletal muscle weakness with elevated serum level of muscle enzymes. It tends to be refractory to conventional drug treatment (glucocorticoid and/or immunosuppressive drugs) and presents frequent relapsing. These manifestations can contribute to both a reduction in strength and functional capacity, and an impairment of aerobic capacity. Differently from other idiopathic inflammatory myopathies (dermatomyositis, polymyositis and inclusion body myositis), to date there are no studies evaluating the effect of physical training on aerobic capacity, strength and muscular function of patients with IMNM. Therefore, the aim of the present study is to assess the physical training impact in patients with IMNM. As control groups, these patients will be compared to patients with polymyositis and also to a healthy group (gender- and age-matched). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE SOUZA, J. M.; DE OLIVEIRA, D. S.; PERIN, L. A.; MISSE, R. G.; DOS SANTOS, A. M.; GUALANO, B.; DE SA PINTO, A. L.; ROSCHEL, H.; LIMA, F. R.; SHINJO, S. K.. Feasibility, safety and efficacy of exercise training in immune-mediated necrotising myopathies: a quasi-experimental prospective study. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 37, n. 2, p. 235-241, MAR-APR 2019. (17/13109-1, 16/23574-0, 17/06794-0, 16/19771-5)