Association between biochemical parameters of the blood serum of pigs fed with different sources of fatty acids and the transcriptomic profile of the liver

• Grant number: 21/06553-8
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Start date: November 01, 2021
• End date: December 14, 2021
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Aline Silva Mello Cesar
• Grantee: Julia Dezen Gomes
• Supervisor: Andreia de Jesus Amaral Gomes Barbosa Fonseca
• Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
• Institution abroad: Universidade de Lisboa, Portugal
• Associated to the scholarship: 20/14148-3 - Evaluation of biochemical parameters of blood serum of swine feeded with different sources of fatty acids, BP.IC

Abstract

Mono (MUFA) and polyunsaturated (PUFA) fatty acids have functional properties, such as anti-inflammatory action, regulation of the immune response, proven effect in the prevention of NCDs, protective effect against viral infections and the development of some types of cancer. There is an important role for PUFAs, such as n-3, in modulating the functions of the immune system, decreasing the severity of inflammatory disorders. The increase in oils rich in PUFAs in the pig diet improves the blood biochemical parameters of the animals. This is due to the fact that these fatty acids have a hypocholesterolemic effect in both humans and pigs. PUFAs increase LDL-cholesterol receptors in cells, increasing secretion of bile acids in bile, that is, increasing the excretion of cholesterol by decreasing its levels in the blood serum. This impact at biochemical level is a consequence of changes at transcriptomic level that still need to be properly investigated. Therefore, it is essential to investigate the changes occurred at transcriptomic level and its relationship with biochemical parameters measured in blood serum for a better understanding of the biological processes involved with metabolic diseases. Thus, the objective of this study is to verify the effect of diets of male pigs immunocastrated in the phases of growth and termination, with different fatty acid profiles, on the biochemical parameters of blood serum and its association with the transcriptomic profile of the liver of these animals. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FANALLI, SIMARA LARISSA; SILVA, BRUNA PEREIRA MARTINS; GOMES, JULIA DEZEN; DURVAL, MARIAH CASTRO; DE ALMEIDA, VIVIAN VEZZONI; MOREIRA, GABRIEL COSTA MONTEIRO; SILVA-VIGNATO, BARBARA; AFONSO, JULIANA; FREITAS, FELIPE ANDRE OLIVEIRA; REECY, JAMES MARK; et al. RNA-seq transcriptome profiling of pigs' liver in response to diet with different sources of fatty acids. FRONTIERS IN GENETICS, v. 14, p. 14-pg., 2023-01-25. (21/06553-8, 20/10042-6, 18/15653-3, 18/26816-0, 14/02493-7, 17/25180-2, 18/26797-6)

FANALLI, SIMARA LARISSA; DA SILVA, BRUNA PEREIRA MARTINS; GOMES, JULIA DEZEN; DE ALMEIDA, VIVIAN VEZZONI; MOREIRA, GABRIEL COSTA MONTEIRO; SILVA-VIGNATO, BARBARA; AFONSO, JULIANA; FREITAS, FELIPE ANDRE OLIVEIRA; REECY, JAMES MARK; KOLTES, JAMES EUGENE; et al. Transcriptome profile of skeletal muscle using different sources of dietary fatty acids in male pigs. FUNCTIONAL & INTEGRATIVE GENOMICS, v. 23, n. 1, p. 19-pg., 2023-03-01. (21/06553-8, 20/10042-6, 18/15653-3, 18/26816-0, 14/02493-7, 17/25180-2, 18/26797-6)