Passion fruit peel intake decreases inflammatory response and reverts lipid peroxidation and adiposity in diet-induced obese rats

Author(s)

Vuolo, Milena Morandi ^[1] ; Lima, Glaucia Carielo ^[2] ; Batista, Angela Giovana ^[3] ; Betim Carazin, Cinthia Bau ^[1] ; Cintra, Dennys Esper ^[4] ; Prado, Marcelo Alexandre ^[1] ; Marostica Junior, Mario Roberto ^[1]

Affiliation

^[1] Univ Estadual Campinas, Sch Food Engn, Food & Nutr Dept, Monteiro Lobato 80, Campinas 13083862, SP - Brazil

^[2] Univ Fed Goias, Nutr Sch, 227 St, Qd 68, S-N Setor Leste Univ, Goiania 74605080, Go - Brazil

^[3] Fed Univ Santa Maria UFSM, Dept Food & Nutr, Palmeira Das Missoes 98300000, RS - Brazil

^[4] Univ Estadual Campinas, Sch Appl Sci, Pedro Zaccaria 1300, Limeira 13484350, SP - Brazil

• Document type: Journal article
• Source: Nutrition Research; v. 76, p. 106-117, APR 2020.
• Web of Science Citations: 0

Abstract

This study investigated Passiflora edulis peel flour (PEPF) intake and its effect against high-fat diet- induced obesity. PEPF is a source of fiber and phenolic compounds, which can decrease oxidative stress and inflammatory cytokines, both linked to chronic inflammatory response and fat deposition in obesity. Therefore, we hypothesized that PEPF intake could decrease inflammatory cytokines and oxidative stress observed in obesity, leading to decrease of fatness and chronic inflammatory response. The aims of the study were to evaluate the lipid peroxidation, the expression of antioxidants enzymes, and inflammatory parameters in obese rats. Male Sprague-Dawley rats were divided into 3 groups (n = 8 per group) according to the diets: control (based on AIN-93G), high-fat (HF, 35% fat w/w), and HF with PEPF (HFPF), and the experiment lasted for 10 weeks. PEPF showed high dietary fiber content and bioactive compounds, such as ferulic acid, and beta-carotene. PEPF intake was effective in reducing body weight gain (13.31%) and total body fat (22.58%). The lipid peroxidation in the liver and adipose tissue decreased in the HFPF group compared to HF-fed animals, whereas hepatic glutathione peroxidase and glutathione reductase activity and their expressions in the liver were higher in HFPF than HF. In addition, the PEPF intake decreased inflammatory cytokines in serum. These results suggest that PEPF intake decreases oxidative stress, possibly by the increase of antioxidant enzymes expression. Furthermore, PEPF decreases inflammatory response and protects from adiposity. Then, PEPF could act as an adjuvant to control of early parameters in obesity dysfunction. (C) 2019 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/12322-0 - Assessing the effects of yellow passion fruit peel flour (Passiflora edulis) in the treatment and / or prevention of obesity and comorbidities in vivo
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
• Grantee: Glaucia Maria Pastore
• Support Opportunities: Research Projects - Thematic Grants