Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling

Author(s)

Lima, Aline de Freitas ^[1] ; Pegorin, Giovana Sant'Ana ^{[2, 1]} ; Romeiro Miranda, Matheus Carlos ^[3] ; Cachaneski-Lopes, Joao Paulo ^[4] ; Silva, William de Melo ^[5] ; Borges, Felipe Azevedo ^[1] ; Guerra, Nayrim Brizuela ^[6] ; Herculano, Rondinelli Donizetti ^[1] ; Batagin-Neto, Augusto ^{[1, 7]}

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Biotechnol & Bioproc Engn, Rodovia Araraquara Jau, Km 01, BR-14800903 Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Chem, Dept Biochem & Chem Technol, Araraquara, SP - Brazil

^[3] Univ Aveiro, Ctr Environm & Marine Studies CESAM, Aveiro - Portugal

^[4] Sao Paulo State Univ UNESP, Sch Sci, Postgrad Program Sci & Technol Mat POSMAT, Bauru, SP - Brazil

^[5] Sao Paulo State Univ UNESP, Inst Biotechnol IBTEC, Dept Bioproc & Biotechnol, Botucatu, SP - Brazil

^[6] Univ Caxias do Sul UCS, Dept Exact Sci & Engn, Caxias Do Sul, RS - Brazil

^[7] Sao Paulo State Univ UNESP, Campus Itapeva, Itapeva - Brazil

• Document type: Journal article
• Source: JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS; v. 19, MAR 2021.
• Web of Science Citations: 0

Abstract

The incorporation of drugs and bioactive compounds in the natural rubber latex (NRL) matrix has been an alternative for the development of transdermal release membranes. Ibuprofen (IBF) is known to be used to treat inflammatory diseases, but when administered orally, high concentrations can cause some adverse problems. In this work, the incorporation of IBF in the NRL membranes was evaluated by physical-chemical, in vitro permeation, hemocompatibility and molecular modeling assays. In addition, the in vitro release profile of IBF in acid and basic media was analyzed during 96 h. The IBF-NRL membrane exhibited the absence of intermolecular bonding that could hinder drug release and presented compatible mechanical properties for applications as a cutaneous adhesive (0.58 and 1.12 MPa to Young's modulus and rupture tension, respectively). The IBF-NRL system did not present a significant hemolysis degree (1.67%) within 24 h. The release test indicated that in the first hours of the study, 48.5% IBF was released at basic pH and 22.5% at acidic pH, which is characteristic of a burst effect. Then, a stable release profile was observed until the end of the assay, with total IBF release of 60% in alkaline medium and 50% in acidic medium. The drug permeation results indicated that the IBF-NRL membranes can be used for the local skin treatment with permeation of 3.11% of IBF. Dynamic Molecular simulations indicated a pronounced electric dipole in the ionized form of IBF, which suggests a more effective interaction with water, explaining the efficient drug release in alkaline solutions. In general, the results demonstrate that the IBF-NRL membrane has great potential for a new adhesive that can be used for the treatment of inflammatory processes and injuries. (AU)

• FAPESP's process: 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/17526-8 - Development of a novel system employing natural rubber latex as releasing of vegetable extracts incorporated with nanoparticles: physical chemical and biological characterization
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/19603-8 - Development of a novel patch containing latex and barbatimam e fractions and study of signaling pathways in cutaneous wound repair
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants