| Full text | |
| Author(s): |
Costa-Fernandez, Sandra
[1]
;
Matos, Jenyffer K. R.
[1]
;
Scheunemann, Gaby S.
[1]
;
Salata, Giovanna C.
[1]
;
Chorilli, Marlus
[2]
;
Watanabe, Il-Sei
[1]
;
de Araujo, Gabriel L. B.
[3]
;
Santos, Marinilce F.
[1]
;
Ishida, Kelly
[1]
;
Lopes, Luciana B.
[1]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Inst Ciencias Biomed, Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil
[3] Univ Sao Paulo, Fac Ciencias Farmacaut, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | International Journal of Biological Macromolecules; v. 183, p. 668-680, JUL 31 2021. |
| Web of Science Citations: | 4 |
| Abstract | |
The high incidence and costs of chronic wounds in the elderly have motivated the search for innovations to improve product performance and the healing process while reducing costs. In this study, bioadhesive nanostructured lipid carriers (NLC) were developed for the co-encapsulation of compounds with antioxidant (a-tocopherol and quercetin) and antimicrobial (tea tree oil) activity for management of wounds. The NLC was produced with shea butter and argan oil, and modified with sodium alginate or chitosan to confer bioadhesive properties. Spherical nanoparticles of similar to 307-330 nm and zeta potential varying from -21.2 to +11.8 mV were obtained. Thermal analysis demonstrated that the lipid matrix reduced tea tree oil thermal loss (similar to 1.8-fold). Regardless of the type of polysaccharide employed, the NLCs promoted cutaneous localization of antioxidants in damaged (subjected to incision) skin, with a similar to 74 to 180-fold higher delivery into the skin compared to percutaneous delivery. This result is consistent with the similar bioadhesive properties of chitosan or sodium alginate-modified NLC. Nanoencapsulation of tea tree oil did not preclude its antimicrobial effects against susceptible and resistant strains of S. aureus and P. aeruginosa, while co-encapsulation of antioxidants increased the NLC-induced fibroblasts migration, supporting their potential usefulness for management of wounds. (C) 2021 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach |
| Grantee: | Maria Vitória Lopes Badra Bentley |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/26048-6 - Development and application of multifunctional nanocarriers for intraductal delivery of chemotherapy aiming at Breast Cancer treatment |
| Grantee: | Giovanna Cassone Salata |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/16617-7 - Nanostructured systems for topical delivery and co-localization of chemopreventive and chemoterapeutic agents in the skin and breast tissue |
| Grantee: | Luciana Biagini Lopes |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 17/19059-6 - Avaliação da irritação local e segurança de nanocarreadores para administração intraductal |
| Grantee: | Jenyffer Kelly Rocha de Matos |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 15/07993-0 - ENCAPSULATION OF MILTEFOSINE INTO MICROPARTICLES OF ALGINATE AND EVALUATION OF EFFECTS "IN VITRO" AND "IN VIVO" ON MURINE MODEL OF PULMONARY CRYPTOCOCCOSIS |
| Grantee: | Kelly Ishida |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/19374-9 - Echinocandins in the control of infections associated to polymicrobial biofilms of Candida spp. and bacteria such as Stapholococcus aureus and Pseudomonas aeruginosa |
| Grantee: | Kelly Ishida |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/13877-1 - Nanocarriers for localized treatment and chemoprevention of breast tumors |
| Grantee: | Luciana Biagini Lopes |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |