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Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing

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Borges, Felipe Azevedo ; Drago, Bruno de Camargo ; Baggio, Luis Otavio ; de Barros, Natan Roberto ; Pegorin Brasil, Giovana Sant'Ana ; Scontri, Mateus ; Mussagy, Cassamo Ussemane ; da Silva Ribeiro, Matheus Cicero ; Pereira Milori, Debora Marcondes Bastos ; de Morais, Carla Pereira ; Marangoni, Bruno Spolon ; Nicolodelli, Gustavo ; Mecwan, Marvin ; Mandal, Kalpana ; Guerra, Nayrim Brizuela ; Menegatti, Carlos Renato ; Herculano, Rondinelli Donizetti
Total Authors: 17
Document type: Journal article
Source: International Journal of Biological Macromolecules; v. 211, p. 12-pg., 2022-05-18.
Abstract

Gold nanoparticles (AuNPs) have shown interesting properties and specific biofunctions, providing benefits and new opportunities for controlled release systems. In this research, we demonstrated the use of natural rubber latex (NRL) from Hevea brasiliensis as a carrier of AuNPs and the antibiotic metronidazole (MET). We prepared AuNP-MET-NRL and characterized by physicochemical, biological and in vitro release assays. The effect of AuNPs on MET release was evaluated using UV-Vis and Laser-Induced Breakdown Spectroscopy (LIBS) techniques. AuNPs synthesized by Turkevich and Frens method resulted in a spherical shape with diameters of 34.8 +/- 5.5 nm. We verified that there was no emergence or disappearance of new vibrational bands. Qualitatively and quantitatively, we showed that the MET crystals dispersed throughout the NRL. The Young's modulus and elongation values at dressing rupture were in the range appropriate for human skin application. 64.70% of the AuNP-MET complex was released within 100 h, exhibiting a second-order exponential release profile. The LIBS technique allowed monitoring of the AuNP release, indicating the Au emission peak reduction at 267.57 nm over time. Moreover, the dressing displayed an excellent hemocompatibility and fibroblast cell viability. These results demonstrated that the AuNP-MET-NRL wound dressing is a promising approach for dermal applications. (AU)

FAPESP's process: 12/12958-1 - Evaluation of drug and nanoparticle delivery system using natural latex as carrier
Grantee:Bruno de Camargo Drago
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 14/17526-8 - Development of a novel system employing natural rubber latex as releasing of vegetable extracts incorporated with nanoparticles: physical chemical and biological characterization
Grantee:Rondinelli Donizetti Herculano
Support Opportunities: Regular Research Grants
FAPESP's process: 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier
Grantee:Rondinelli Donizetti Herculano
Support Opportunities: Regular Research Grants
FAPESP's process: 20/08655-0 - Development of a sustainable and biocompatible technology for Astaxanthin recovery and purification: a powerful antioxidant with economic value
Grantee:Cassamo Ussemane Mussagy
Support Opportunities: Scholarships in Brazil - Post-Doctoral