Acute intake of lipids and changes in cerebral perfusion in obese patients

• Grant number: 12/03485-2
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2012
• End date: August 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Julio Sergio Marchini
• Grantee: Julio Sergio Marchini
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Carla Barbosa Nonino ; Lauro Wichert Ana

Abstract

Obesity and related illnesses emerge as public health problem worldwide since the mid 80's. Characterized by the accumulation of body fat, its pathophysiology can not be solely explained by an imbalance between energy intake and consumption. There are a number of genetic, humoral, environmental and behavioral interconnected but not fully elucidated, contributing to positive energy balance and subsequent weight gain. Not much is known about the interaction between nutrient intake and physical changes of the central nervous system. Objective: To identify, through Single-Photon Emission Tomography (SPECT) after stimulation of water and lipid solution, which are the brain anatomical structures involved in lipid intake. Compare the cerebral perfusion of obese volunteers to their non-obese controls. Finally, increase the knowledge about how does the acute intake of isolated macronutrients, in this case the lipid, influence the obesity pathophysiology. Methodology: A crossed case control study, where ten obese and ten non-obese volunteers will be evaluated by clinical examination, underwent to indirect calorimetry (IC), bioelectrical impedance analysis (BIA), laboratory tests (glucose, insulin, leptin and triglycerides) and SPECT after stimulation of water and lipid solution. The results will be compared with the existing literature in order to better clarify how a single macronutrient, in this case, the lipid, contributes to pathophysiology of obesity. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVAH, JOSE HENRIQUE; MARCHINI, JULIO SERGIO; MARTIRES LIMA, CRISTIANE MARIA; NICOLETTI, CAROLINA FERREIRA; SANTOS, LEONARDO ALEXANDRE; ITIKAWA, EMERSON NOBUYUKI; TREVISAN, ANA CAROLINA; PITELLA, FELIPE ARRIVA; KATO, MERY; IUCIF JUNIOR, NELSON; et al. Regional cerebral blood flow at rest in obesity. NUTRITION, v. 79-80, NOV-DEC 2020. (12/21579-4, 10/19821-6, 12/03485-2, 12/21626-2)