High Risk Cohort Study for Psychiatric Disorders in Childhood: 3-year follow-up neuroimaging study

• Grant number: 13/08531-5
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2014
• End date: March 31, 2017
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Andrea Parolin Jackowski
• Grantee: Andrea Parolin Jackowski
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated researchers: Eurípedes Constantino Miguel Filho ; João Ricardo Sato ; Luis Augusto Paim Rohde ; Rodrigo Affonseca Bressan
• Associated research grant(s): 15/50469-0 - Incidence and effects of toxic stress on neurodevelopmental,cognitive and socioemotional outcomes in children and adolescents:a cross national comparative collaboration. (sprint 3/2015), AP.R SPRINT

Abstract

It has been suggested that psychiatric disorders can evolve from an atypical neurodevelopmental process. It is crucial to understand the typical trajectory of neurodevelopment and their periods of greatest vulnerability to study the possible implications of deviations in the pathophysiology of mental disorders. This study aims to evaluate the differences in the trajectories of brain development in healthy children, children at high-risk for mental disorders, children diagnosed with psychopathology at baseline and at three years of follow up. This cohort consists of 750 children aged 7-15 years from the National Institute for Developmental Psychiatry for Children and Adolescents (INCT-INPD). The INPD is the largest national cohort study, and one of the largest international cohorts whose objective is to evaluate the origin of neurodevelopmental atypical trajectory and their expression as mental illness, and also to establish new strategies for prevention and treatment for these disorders. From the initial sample, all subjects will be reassessed 3 years after the baseline using the same battery questionnaires. Clinical evaluation includes, but is not limited to the re-application of DAWBA, M.I.N.I., stressors evaluation and symptom scale. The same individuals who underwent to a Magnetic Resonance Imaging (MRI) at baseline in Sao Paulo (n=375 from a total of 750 of the original cohort) will be invited to repeat the procedure. With the follow-up study we aim to evaluate and identify the profiles of developmental trajectory for both structural and functional aspects of the brain and thus advance the understanding of the pathogenesis of psychiatric disorders. We believe that this study will contribute significantly to new approaches for early detection and risk factors related to mental disorders (AU)

Scientific publications

(25)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

BIAZOLI JR, CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; REBELLO, KEILA; MOURA, LUCIANA MONTEIRO; PAN, PEDRO MARIO; BRIETZKE, ELISA; MIGUEL, EURIPEDES CONSTANTINO; ROHDE, LUIS AUGUSTO; BRESSAN, RODRIGO AFFONSECA; et al. Socioeconomic status in children is associated with spontaneous activity in right superior temporal gyrus. BRAIN IMAGING AND BEHAVIOR, v. 14, n. 4, p. 961-970, AUG 2020. (13/00506-1, 13/08531-5, 13/10498-6, 08/57896-8)

SATO, JOAO RICARDO; BIAZOLI, CLAUDINEI EDUARDO; ZUGMAN, ANDRE; PAN, PEDRO MARIO; ARANTES BUENO, ANA PAULA; MOURA, LUCIANA MONTEIRO; GADELHA, ARY; PICON, FELIPE ALMEIDA; AMARO JR, EDSON; SALUM, GIOVANNI ABRAHAO; et al. Long-term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence. European Journal of Neuroscience, v. 54, n. 6, SEP 2021. (18/21934-5, 16/19376-9, 13/08531-5, 14/50917-0, 18/04654-9)

VATTIMO, EDOARDO F. Q.; DOS SANTOS, ALLAN CHRISTIANO; HOEXTER, MARCELO Q.; FRUDIT, PAULA; MIGUEL, EURIPEDES C.; SHAVITT, ROSELI G.; BATISTUZZO, MARCELO C.. Higher volumes of hippocampal subfields in pediatric obsessive-compulsive disorder. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 307, JAN 30 2021. (09/09949-8, 13/08531-5, 14/50917-0)

SATO, JOAO RICARDO; BIAZOLI JR, CLAUDINEI EDUARDO; MOURA, LUCIANA MONTEIRO; CROSSLEY, NICOLAS; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; HOEXTER, MARCELO QUEIROZ; AMARO JR, EDSON; MIGUEL, EURIPEDES CONSTANTINO; ROHDE, LUIS AUGUSTO; et al. Association Between Fractional Amplitude of Low-Frequency Spontaneous Fluctuation and Degree Centrality in Children and Adolescents. BRAIN CONNECTIVITY, v. 9, n. 5, p. 379-387, JUN 1 2019. (16/04983-7, 13/08531-5, 18/21934-5, 14/50917-0, 18/04654-9)

DE MOURA, ADRIANA MIYAZAKI; LOPEZ PINAYA, WALTER HUGO; GADELHA, ARY; ZUGMAN, ANDRE; NOTO, CRISTIANO; CORDEIRO, QUIRINO; BELANGERO, SINTIA IOLE; JACKOWSKI, ANDREA P.; BRESSAN, RODRIGO A.; SATO, JOAO RICARDO. Investigating brain structural patterns in first episode psychosis and schizophrenia using MRI and a machine learning approach. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 275, p. 14-20, MAY 30 2018. (13/10498-6, 13/08531-5, 14/07280-1, 13/05168-7)

SATO, JOAO RICARDO; BIAZOLI, JR., CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; et al. Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation. DEVELOPMENTAL COGNITIVE NEUROSCIENCE, v. 20, p. 2-11, AUG 2016. (13/00506-1, 13/08531-5, 13/10498-6, 08/57896-8)

LEFFA, DOUGLAS TEIXEIRA; CAYE, ARTHUR; BELANGERO, SINTIA I.; GADELHA, ARY; PAN, PEDRO MARIO; SALUM, GIOVANNI ABRAHAO; ROHDE, LUIS AUGUSTO. The synergistic effect of genetic and environmental factors in the development of attention-deficit/hyperactivity disorder symptoms in children and adolescents. DEVELOPMENT AND PSYCHOPATHOLOGY, v. N/A, p. 11-pg., 2023-04-24. (14/50917-0, 13/08531-5)

PAN, PEDRO MARIO; SATO, JOAO R.; MARTINOT, MARIE-LAURE PAILLERE; MARTINOT, JEAN-LUC; ARTIGES, ERIC; PENTTILA, JANI; GRIMMER, YVONNE; VAN NOORT, BETTEKE M.; BECKER, ANDREAS; BANASCHEWSKI, TOBIAS; et al. Longitudinal Trajectory of the Link Between Ventral Striatum and Depression in Adolescence. American Journal of Psychiatry, v. 179, n. 7, p. 12-pg., 2022-07-01. (13/08531-5, 14/50917-0)

ANDRÉ ZUGMAN; JOÃO R. SATO; ANDREA P. JACKOWSKI. Crisis in neuroimaging: is neuroimaging failing 15 years after the decade of the brain?. Revista Brasileira de Psiquiatria, v. 38, n. 4, p. 267-269, 2016-12-00. (13/00506-1, 13/10498-6, 13/08531-5)

VATTIMO, EDOARDO F. Q.; BARROS, VIVIAN B.; REQUENA, GUARACI; SATO, JOAO R.; FATORI, DANIEL; MIGUEL, EURIPEDES C.; SHAVITT, ROSELI G.; HOEXTER, MARCELO Q.; BATISTUZZO, MARCELO C.. Caudate volume differences among treatment responders, non-responders and controls in children with obsessive-compulsive disorder. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 28, n. 12, p. 1607-1617, DEC 2019. (13/08531-5, 18/21934-5, 18/04654-9, 14/50917-0, 09/09949-8)

REBELLO, KEILA; MOURA, LUCIANA M.; XAVIER, GABRIELA; SPINDOLA, LETICIA M.; CARVALHO, CAROLINA MUNIZ; HOEXTER, MARCELO QUEIROZ; GADELHA, ARY; PICON, FELIPE; PAN, PEDRO MARIO; ZUGMAN, ANDRE; et al. Association between spontaneous activity of the default mode network hubs and leukocyte telomere length in late childhood and early adolescence. JOURNAL OF PSYCHOSOMATIC RESEARCH, v. 127, DEC 2019. (13/08531-5, 18/21934-5, 14/50917-0, 14/07280-1, 18/04654-9)

DE ARAUJO, CELIA MARIA; ZUGMAN, ANDRE; SWARDFAGER, WALTER; NOGUEIRA BELANGERO, SINTIA IOLE; OTA, VANESSA KIYOMI; SPINDOLA, LETICIA MARIA; HAKONARSON, HAKON; PELLEGRINO, RENATA; GADELHA, ARY; SALUM, GIOVANNI ABRAHAO; et al. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. JOURNAL OF PSYCHIATRIC RESEARCH, v. 98, p. 51-58, MAR 2018. (13/08531-5, 14/07280-1, 14/50917-0)

SATO, JOAO RICARDO; BIAZOLI JR, CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; et al. Associations between children's family environment, spontaneous brain oscillations, and emotional and behavioral problems. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 28, n. 6, p. 835-845, JUN 2019. (13/10498-6, 13/08531-5, 13/00506-1)

DIAS, TACIANA G. COSTA; SATO, JOAO R.; FAIR, DAMIEN A.; SALUM, GIOVANNI A.; ROHDE, LUIS A.; BRESSAN, RODRIGO A.; PAN, PEDRO M.; JACKOWSKI, ANDREA P.; POLANCZYK, GUILHERME V.. CATEGORICAL AND DIMENSIONAL ASSESSMENT OF NUCLEUS ACCUMBENS AND AMYGDALA CONNECTIVITY IN DISRUPTIVE BEHAVIOR DISORDERS AND ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD). JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, v. 56, n. 10, p. 1-pg., 2017-10-01. (14/50917-0, 13/08531-5)

DORETTO, VICTORIA FOGACA; SALTO, ANA BEATRIZ RAVAGNANI; SCHIVOLETTO, SANDRA; ZUGMAN, ANDRE; OLIVEIRA, MELAINE CRISTINA; BRANAS, MARCELO; CROCI, MARCOS; ITO, LUCAS TOSHIO; SANTORO, MARCOS; JACKOWSKI, ANDREA P.; et al. Childhood maltreatment and the structural development of hippocampus across childhood and adolescence. PSYCHOLOGICAL MEDICINE, v. 54, n. 16, p. 9-pg., 2025-01-08. (13/08531-5, 14/50917-0, 21/02451-6)

MOURA, L. M.; CROSSLEY, N. A.; ZUGMAN, A.; PAN, P. M.; GADELHA, A.; DEL AQUILLA, M. A. G.; PICON, F. A.; ANES, M.; AMARO, JR., E.; DE JESUS MARI, J.; et al. Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation. BRAIN IMAGING AND BEHAVIOR, v. 11, n. 3, p. 808-817, JUN 2017. (13/00506-1, 13/08531-5, 13/10498-6, 08/57896-8)

SATO, JOAO RICARDO; BIAZOLI, JR., CLAUDINEI EDUARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; et al. Association between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v. 19, n. 2, p. 119-129, 2018. (13/08531-5, 08/57896-8, 13/10498-6, 13/00506-1)

BATISTUZZO, MARCELO C.; SOTTILI, BRUNA A.; SHAVITT, ROSELI G.; LOPES, ANTONIO C.; CAPPI, CAROLINA; DE MATHIS, MARIA ALICE; PASTORELLO, BRUNO; DINIZ, JULIANA B.; SILVA, RENATA M. F.; MIGUEL, EURIPEDES C.; et al. Lower Ventromedial Prefrontal Cortex Glutamate Levels in Patients With Obsessive-Compulsive Disorder. FRONTIERS IN PSYCHIATRY, v. 12, JUN 8 2021. (11/21357-9, 13/08531-5, 14/50917-0, 16/05865-8)

HOEXTER, MARCELO Q.; BIAZOLI, JR., CLAUDINEI E.; ALVARENGA, PEDRO G.; BATISTUZZO, MARCELO C.; SALUM, GIOVANNI A.; GADELHA, ARY; PAN, PEDRO M.; ANES, MAURICIO; MANCINI-MARTINS, LETICIA; MOURA, LUCIANA M.; et al. Low frequency fluctuation of brain spontaneous activity and obsessive compulsive symptoms in a large school-age sample. JOURNAL OF PSYCHIATRIC RESEARCH, v. 96, p. 224-230, JAN 2018. (13/08531-5, 08/57896-8, 13/00506-1, 16/05865-8, 16/02246-5, 12/50722-0, 13/10498-6)

MOURA, LUCIANA MONTEIRO; KEMPTON, MATTHEW; BARKER, GARETH; SALUM, GIOVANNI; GADELHA, ARY; PAN, PEDRO MARIO; HOEXTER, MARCELO; GOMES DEL AQUILLA, MARCO ANTONIO; PICON, FELIPE ALMEIDA; ANES, MAURICIO; et al. Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence. MAGNETIC RESONANCE IMAGING, v. 34, n. 4, p. 529-534, MAY 2016. (13/00506-1, 13/08531-5, 13/10498-6)

PAN, PEDRO MARIO; SATO, JOAO R.; SALUM, GIOVANNI A.; ROHDE, LUIS A.; GADELHA, ARY; ZUGMAN, ANDRE; MARI, JAIR; JACKOWSKI, ANDREA; PICON, FELIPE; MIGUEL, EURIPEDES C.; et al. Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample. American Journal of Psychiatry, v. 174, n. 11, p. 1112-1119, NOV 1 2017. (13/08531-5, 14/50917-0)

SATO, JOAO RICARDO; SALUM, GIOVANNI ABRAHAO; GADELHA, ARY; CROSSLEY, NICOLAS; VIEIRA, GILSON; MANFRO, GISELE GUS; ZUGMAN, ANDRE; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; HOEXTER, MARCELO QUEIROZ; et al. Default mode network maturation and psychopathology in children and adolescents. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, v. 57, n. 1, p. 55-64, JAN 2016. (13/00506-1, 13/08531-5, 13/10498-6)

DE ARAUJO, CELIA MARIA; SWARDFAGER, WALTER; ZUGMAN, ANDRE; COGO-MOREIRA, HUGO; BELANGERO, SINTIA I.; OTA, VANESSA K.; SPINDOLA, LETICIA M.; HAKONARSON, HAKON; PELLEGRINO, RENATA; GADELHA, ARY; et al. Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?. CNS SPECTRUMS, v. 25, n. 6, p. 790-796, DEC 2020. (14/07280-1, 13/08531-5, 16/04983-7, 14/50917-0)

SATO, JOAO RICARDO; BIAZOLI, CLAUDINEI EDUARDO; BUENO, ANA PAULA ARANTES; CAYE, ARTHUR; PAN, PEDRO MARIO; SANTORO, MARCOS; HONORATO-MAUER, JESSICA; SALUM, GIOVANNI ABRAHAO; HOEXTER, MARCELO QUEIROZ; BRESSAN, RODRIGO AFFONSECA; et al. Polygenic risk score for attention-deficit/hyperactivity disorder and brain functional networks segregation in a community-based sample. GENES BRAIN AND BEHAVIOR, v. N/A, p. 9-pg., 2023-02-21. (18/04654-9, 16/13737-0, 13/08531-5, 21/05332-8, 16/04983-7, 18/21934-5)

RIBEIRO, SAHAMIA MARTINS; CAYE, ARTHUR; FITZPATRICK, CAROLINE; DA SILVA-JR, FRANCISCO; HAAS, LETICIA MULLER; DE GIUSTI, CARINA; SALTO, ANA BEATRIZ RAVAGNANI; BRESSAN, RODRIGO AFFONSECA; MIGUEL, EURIPEDES CONSTANTINO; ROHDE, LUIS AUGUSTO; et al. Incidence and persistence of internalizing disorders from late childhood to young adulthood: an 8-year follow-up analysis of a community-based cohort. Journal of Affective Disorders, v. 392, p. 10-pg., 2025-09-03. (13/08531-5, 21/12901-9, 20/06172-1, 14/50917-0, 21/05332-8, 23/00437-1)