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Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy

Grant number: 15/03756-4
Support type:Research Projects - Thematic Grants
Duration: March 01, 2017 - February 28, 2022
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Eloisa Silva Dutra de Oliveira Bonfá
Grantee:Eloisa Silva Dutra de Oliveira Bonfá
Home Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Co-Principal Investigators:Clovis Artur Almeida da Silva ; Nádia Emi Aikawa ; Sandra Gofinet Pasoto
Assoc. researchers:Alberto José da Silva Duarte ; Ana Cristina de Medeiros Ribeiro ; Carla Gonçalves Schahin Saad ; Eduardo Ferreira Borba Neto ; Esper Georges Kallás ; Gilberto de Nucci ; Pedro Carlos Carricondo ; Rosa Maria Rodrigues Pereira ; Valdemir Melechco Carvalho ; Vilma dos Santos Trindade Viana
Associated grant(s):17/03983-6 - Liquid chromatography coupled to mass spectrometry (2015/03756-4), AP.EMU
Associated scholarship(s):19/21211-6 - Salivary hydroxychloroquine levels: relevance in juvenile systemic lupus erythematosus (JSLE) disease activity and renal disease activity in adult systemic lupus erythematosus, BP.IC
19/21173-7 - Evaluation of the treatment of cutaneous lupus erythematosus with thalidomide: clinical, laboratory and histological factors associated with clinical response and adverse effects, BP.IC
19/17272-0 - Relevance of monitoring blood levels compared to salivar levels of drugs used in rheumatic autoimmune diseases: adherence and understanding the possible underlying mechanisms involved in effectiveness and in adverse effects, BP.PD
+ associated scholarships 18/21594-0 - Analysis of the immune profile of saliva and serum of patients with primary Sjögren's syndrome, BP.IC
18/09937-9 - Analysis of the immune profile of saliva and serum of patients with primary Sjogren's Syndrome, BP.DD
17/14352-7 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, BP.PD
17/11516-9 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, BP.PD
17/11854-1 - Assessment of serum levels of anti-tumor necrosis factor (anti-TNF) and anti-drug antibodies (ADA) in patients with chronic inflammatory arthritis: ankylosing spondylitis and psoriatic arthritis, BP.IC
17/11644-7 - Blood and salivary levels of hydroxychloroquine: relevance in juvenile systemic lupus erythematosus disease (JSLE), in kidney disease in adult SLE activity and in alpha-interferon / TNF production by plasmacytoid dendritic cells, BP.TT
17/07966-9 - Assessment of serum levels of anti-tumor necrosis factor (anti-TNF) and anti-drug antibodies (ADA) in patients with chronic inflammatory arthritis: ankylosing spondylitis and psoriatic arthritis, BP.IC
17/07964-6 - Evaluation of serum levels of anti-tumor necrosis factor (antiTNF) and anti-drug (ada) antibodies in patients with chronic inflammatory arthritis - juvenile idiopathic arthritis, BP.IC - associated scholarships

Abstract

No drug treatment is completely free of risk and lack of response, adverse events and poor adherence may affect its effectiveness. There is also a large inter-individual variability in response to treatments with regard to efficacy and toxicity, and for many drugs, there is also a period of weeks to months to establish its efficacy. Within this context, this project aims to evaluate the importance of monitoring blood levels and salivary drug used in rheumatic autoimmune diseases in the monitoring of adherence to therapy. In addition, this project intends to use the monitoring of drug levels, based on pharmacokinetic studies and pharmacokinetics/pharmacodynamics modeling, to broaden the understanding of the possible cellular, tissue and immunological mechanisms involved in efficacy and adverse effects of these drugs with the prospect of reducing the damage and maintain therapeutic efficacy. The high-performance liquid chromatography (HPLC) coupled to mass spectrometry, which will be used to evaluate hydroxychloroquine, thalidomide, glucocorticoids, is considered the gold standard technology to qualitative and quantitative analysis of drugs in blood and its comparison with the dosage in the saliva is an improvement in simplification of the process. The implementation of this methodology dedicated to research in our center, with the necessary training of human resources, will enable the standardization and availability of this advanced technology to other muldisciplinary projects in various areas of science. For biological agents the focus will be on the understanding the loss of efficacy and the possible role of anti-TNF antibodies using ELISA capture methodology.This thematic project will be divided into four sections with their respective sub-projects according to the medications that will be studied: hydroxychloroquine, thalidomide, biologic agents and glucocorticoids. (AU)

Scientific publications (31)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MENDES, CRISTIANE; VIANA, VILMA S. T.; PASOTO, SANDRA G.; LEON, ELAINE P.; BONFA, ELOISA; SAMPAIO-BARROS, PERCIVAL D. Clinical and laboratory features of African-Brazilian patients with systemic sclerosis. CLINICAL RHEUMATOLOGY, v. 39, n. 1, p. 9-17, JAN 2020. Web of Science Citations: 0.
CAROLINE GOUVEIA BUFF PASSONE; SANDRA JOSEFINA GRISI; SYLVIA COSTA FARHAT; THAIS DELLA MANNA; ANTONIO CARLOS PASTORINO; RENATA ANTUNES ALVENO; CAROLINE VASCONCELOS SÁ MIRANDA; AURORA ROSARIA WAETGE; MARIANA NUTTI CORDON; VICENTE ODONE-FILHO; UENIS TANNURI; WERTHER BRUNOW CARVALHO; MAGDA CARNEIRO-SAMPAIO; CLOVIS ARTUR SILVA. COMPLEXITY OF PEDIATRIC CHRONIC DISEASE: CROSS-SECTIONAL STUDY WITH 16,237 PATIENTS FOLLOWED BY MULTIPLE MEDICAL SPECIALTIES. Revista Paulista de Pediatria, v. 38, p. -, 2020.
FERREIRA, V, GABRIELA R.; TOMIOKA, RENATO B.; QUEIROZ, LIGIA B.; KOZU, KATIA; AIKAWA, NADIA E.; SALLUM, ADRIANA M. E.; SERAFINI, PAULO; TACLA, MARICY; BARACAT, EDMUND C.; PEREIRA, ROSA M. R.; BONFA, ELOISA; SILVA, CLOVIS A. Lower genital tract infections in young female juvenile idiopathic arthritis patients. ADVANCES IN RHEUMATOLOGY, v. 59, n. 1 NOV 15 2019. Web of Science Citations: 0.
BRUNELLI, JULIANA BARBOSA; SILVA, CLOVIS ALMEIDA; PASOTO, SANDRA GOFINET; SCHAHIN SAA, CARLA GONCALVES; KOZU, KATIA TOMIE; GOLDENSTEIN-SCHAINBERG, CLAUDIA; LEON, ELAINE PIRES; VENDRAMINI, MARGARETE B. G.; FONTOURA, NICOLE; BONFA, ELOISA; AIKAWA, NADIA EMI. Anti-adalimumab antibodies kinetics: an early guide for juvenile idiopathic arthritis (JIA) switching. CLINICAL RHEUMATOLOGY, NOV 2019. Web of Science Citations: 1.
FIOROT, FERNANDA J.; ISLABAO, ALINE G.; PEREIRA, ROSA M.; TERRERI, MARIA T.; SAAD-MAGALHAES, CLAUDIA; NOVAK, V, GLAUCIA; MOLINARI, BEATRIZ C.; SAKAMOTO, ANA P.; AIKAWA, NADIA E.; CAMPOS, LUCIA M.; PERACCHI, OCTAVIO A.; APPENZELLER, SIMONE; FERRIANI, VIRGINIA P.; SILVA, MARCO F.; FONSECA, ADRIANA R.; SZTAJNBOK, FLAVIO R.; PAIM, LUCIANA B.; FRAGA, MELISSA M.; OKUDA, EUNICE M.; BICA, BLANCA E.; SENA, EVALDO G.; MORAES, ANA J.; ROLIM, ANA M.; SPELLING, PAULO F.; SCHEIBEL, ILOITE M.; CAVALCANTI, ANDRE S.; MATOS, ERICA N.; ROBAZZI, TERESA C.; GUIMARAES, LUCIANO J.; SANTOS, FLAVIA P.; RAMOS, VALERIA C.; CARNEIRO-SAMPAIO, MAGDA; BONFA, ELOISA; SILVA, CLOVIS A.; LUP, BRAZILIAN CHILDHOOD-ONSET SYST. Disease presentation of 1312 childhood-onset systemic lupus erythematosus: influence of ethnicity. CLINICAL RHEUMATOLOGY, v. 38, n. 10, p. 2857-2863, OCT 2019. Web of Science Citations: 0.
FERREIRA, GABRIELA R. V.; TOMIOKA, RENATO B.; AIKAWA, NADIA E.; LEON, ELAINE P.; MACIEL, GUSTAVO A. R.; SERAFINI, PAULO C.; BARACAT, EDMUND C.; GOLDENSTEIN-SCHAINBERG, CLAUDIA; PEREIRA, ROSA M. R.; BONFA, ELOISA; SILVA, CLOVIS A. Ovarian reserve in young juvenile idiopathic arthritis patients. MODERN RHEUMATOLOGY, v. 29, n. 3, p. 447-451, MAY 4 2019. Web of Science Citations: 2.
BRUNNER, HERMINE I.; HOLLAND, MICHAEL J.; BERESFORD, MICHAEL W.; ARDOIN, STACY P.; APPENZELLER, SIMONE; SILVA, CLOVIS A.; FLORES, FRANCISCO; AYDIN, PINAR OZGE AVAR; WENDERFER, SCOTT E.; LEVY, DEBORAH M.; RAVELLI, ANGELO; KHUBCHANDANI, RAJU; AVCIN, TADEJ; KLEIN-GITELMAN, MARISA S.; RUPERTO, NICOLINO; FELDMAN, BRIAN M.; YING, JUN; BATTAGLIOTTI, CRISTINA; BRUSCO, MARIA ISABEL; CUTTICA, RUBEN; DE CUNTO, CARMEN; ESPADA, GRACIELA; FARFAN, MAXIMILIANO; GARAY, STELLA; MARCANTONI, MARIA; MARCELA, ALVAREZ; MEIORIN, SILVIA; RAMA, MARIA ELENA; RUSSO, RICARDO; WALSH, CAROLINA TORRE; ZAMPARO, CELSO; ADIB, NAVID; AKIKUSA, JONATHAN; BOROS, CHRISTINA; LEE, SENQ J.; MCKAY, DAMIEN; PIPER, SUSAN; JOOS, RIK; BICA, BLANCA; CAMPOS, LEONARDO; CAVALCANTI, ANDRE; DO PRADO, ROGERIO; DONNER-MALIKI, AMANDA; FERNANDES, TACIANA; FONSECA, ADRIANA; DE ALMEIDA, ROZANA GASPARELLO; GUARIENTO, ANDRESSA; GUSMAN, CATHERINE; FIOROT, FERNANDA JUSAN; OLIVEIRA, SHEILA KNUPP; LEN, CLAUDIO; CAMPOS, LUCIA M. ARRUDA; MACHADO, SANDRA; MARQUES, LUCIANA; DE CARVALHO, LUCIANA MARTINS; MOULIN, RODRIGO; PEDROSO, SORAYA; PILEGGI, GECILMARA; ROMANELLI, PAULO ROBERTO S.; SAAD-MAGALHAES, CLAUDIA; SAKAMOTO, ANA; SANTOS, MARIA CAROLINA; SILVA, MARCO FELIPE; SPELLING, PAULO; SZTAJNBOK, SLAVIO; TERRERI, MARIA; CABRAL, DAVID; CHEDEVILLE, GAELLE; ELLSWORTH, JANET; HUBER, ADAM; TUCKER, LORI; HOUGHTON, KRISTIN; BORZUTZKY, ARTURO; LADINO, MABEL; NORAMBUENA, XIMENA; ERASO, RUTH; MOSQUERA, ANGELA; VELASQUEZ, MONICA; HARJACEK, MIROSLAV; JELUSIC, MARIJA; HERMOSILLA, CECILIA COTO; DOLEZALOVA, PAVLA; NIELSEN, SUSAN; TINEO, CARMEN; ALEGRIA, MAURICIO; DRESSLER, FRANK; FOELL, DIRK; GANSER, GERD; HINZE, CLAAS; HUFNAGEL, MARKUS; LUTZ, THOMAS; TRAUZEDDEL, RALF; BOIU, SORINA; TRACHANA, MARIA; TSITSAMI, ELENA; CIFUENTES, MAYRA; ORBAN, ILONKA; AGGARWAL, AMITA; SAWHNEY, SUJATA; AVIEL, YONATAN BUTBUL; CIMAZ, ROLANDO; MAGGIO, MARIA CRISTINA; RUMBA-ROZENFELDE, INGRID; HASHAD, SOAD; LIM, SERN CHIN; ABUD, CARLOS; BURGOS-VARGAS, RUBEN; CARRENO-MANJARREZ, ROBERTO; ENCISO PELAEZ, SANDRA; HERNANDEZ-HUIRACHE, HAYDE; MALDONADO VELAZQUEZ, ROCIO; OROZCO, JAVIER; RODRIGUEZ-LOZANO, ANA LUISA; ROJAS PACHECO, OMAR ERNESTO; SUAREZ LARIOS, LUZ MARIA; VEGA, GABRIEL; RAMIREZ MIRAMONTES, JULIA VERONICA; RUIZ LOPEZ, IVON KARINA; KAMPHUIS, SYLVIA; SCHONENBERG-MEINEMA, DIENEKE; CONCANNON, ANTHONY; YAN, JAQUELINE; JAIME, MARTHA JARQUIN; AL ABRAWI, SAFIYA; VEGA, CYNTHIA; LOPEZ-BENITEZ, JORGE; ESTRELLA, AMPARO IBANEZ; MIRAVAL, TATIANA; DANS, LEONIA; KIMSENG, KAREN JOY; OPOKA-WINIARSKA, VIOLETTA; RUTKOWSKA-SAK, LIDIA; SMOLEWSKA, ELZBIETA; CONDE, MARTA; GUEDES, MARGARIDA; DEL VALLE, ENID; QUINTERO-DEL RIO, ANA; AILIOAIE, CONSTANTIN; SPARCHEZ, MIHAELA; ALEKSEEVA, EKATERINA; KELTSEV, VLADIMIR; AL-MAYOUF, SULAIMAN; ASIRI, ABDURHMAN; SUWAIRI, WAFAA; SUSIC, GORDANA; VIJATOV-DJURIC, GORDANA; ANG, ELIZABETH; ARKACHAISRI, THASCHAWEE; BOTEANU, ALINA-LUCICA; LOPEZ-ROBLEDILLO, JUAN CARLOS; SAN ILDEFONSO, MARTA MEDRANO; MODESTO, CONSUELO; CALVO, INMACULADA; SOTOCA-FERNANDEZ, JORGE; BOLT, ISABEL; VILAIYUK, SOAMARAT; AL-ABADI, ESLAM; BAILDAM, EILEEN; FOTIS, LAMPROS; PAIN, CLARE; PILKINGTON, CLARISSA; ABULABAN, KHALID; BARBAR-SMILEY, FATIMA; BINSTADT, BRYCE; BOHNSACK, JOHN; BONEPARTH, ALEXIS; BROWN, DIANE; CHIRA, PETER; CRON, RANDY; DEDEOGLU, FATMA; EBERHARD, ANNE; GEDALIA, ABRAHAM; GROM, ALEXEI; GOILAV, BEATRICE; HENRICKSON, MICHAEL; HOM, CHRISTINE; HUGGINS, JENNIFER; JERATH, RITA; JONES, JORDAN; JUNG, LAWRENCE; KINGSBURY, DANIEL; LAI, JAMIE; LOVELL, DANIEL; NANDA, KABITA; NOCTON, JAMES; OLSON, JUDYANN; O'NEIL, KATHLEEN; ONEL, KAREN; PUNARO, LYNN; ROUSTER-STEVENS, ANDREAS REIFF KELLY; RUTH, NATASHA; SCHIKLER, KEN; SCHMIDT, KARA MURPHY; SCHULERT, GRANT; SHAHAM, BRACHA; SINGER, NORA; SMITH, JUDITH; SUNDEL, ROBERT; SYVERSON, GRANT; VEGA-FERNANDEZ, PATRICIA; VEHE, RICHARD; WAGNER-WEINER, LINDA; CAMETO, JUAN; JURADO, ROSARIO; MALDONADO, IRAMA; ORG, PAEDIAT RHEUMATOLOGY INT TRIAL; COLLABORATIVE, PEDIAT RHEUMATOLOGY. American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus. ARTHRITIS CARE & RESEARCH, v. 71, n. 5, p. 579-590, MAY 2019. Web of Science Citations: 0.
PITTA, ANA CLAUDIA; VIOLA FERREIRA, GABRIELA RIBEIRO; TOMIOKA, RENATO BUSSADORI; RODRIGUES LOURENCO, DANIELA MENCARONI; KOZU, KATIA; AIKAWA, NADIA EMI; ELIAS SALLUM, ADRIANA MALUF; ARRUDA CAMPOS, LUCIA MARIA; NAJJAR ABDO, CARMITA HELENA; RODRIGUES PEREIRA, ROSA MARIA; BARACAT, EDMUND CHADA; BONFA, ELOISA; SILVA, CLOVIS ARTUR. Sexual function in female juvenile idiopathic arthritis patients. ADVANCES IN RHEUMATOLOGY, v. 59, MAR 22 2019. Web of Science Citations: 0.
KUHNE, A. C. A.; PITTA, A. C.; GALASSI, S. C.; GONCALVES, A. M. F.; CARDOSO, A. C. A.; PAZ, J. A.; CAMPOS, L. M. A.; SILVA, C. A. Munchausen by proxy syndrome mimicking childhood-onset systemic lupus erythematosus. Lupus, v. 28, n. 2, p. 249-252, FEB 2019. Web of Science Citations: 0.
TISEO, B. C.; BONFA, E.; BORBA, E. F.; MUNHOZ, G. A.; WOOD, G. J. A.; SROUGI, M.; SILVA, C. A.; COCUZZA, M. Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients. Lupus, v. 28, n. 1, p. 59-65, JAN 2019. Web of Science Citations: 1.
CLOVIS ARTUR SILVA. POOR ADHERENCE TO DRUG TREATMENT IN CHILDREN AND ADOLESCENTS WITH AUTOIMMUNE RHEUMATIC DISEASES. Revista Paulista de Pediatria, v. 37, n. 2, p. 138-139, Abr. 2019.
ETRUSCO ZARONI SANTOS, ANA CAROLINA; LUGLIO, MICHELE; DELGADO, ARTUR FIGUEIREDO; SANTO VIEIRA SCHUWARTZ, CONSTANCE DELL; SOUSA MARQUES, HELOISA HELENA; DE MIRANDA VALOES, CLARISSA CARVALHO; CABRERA DOMINGUEZ, MARIA ANDREINA; DE CARVALHO, WERTHER BRUNOW; SILVA, CLOVIS ARTUR; DUARTE-NETO, AMARO NUNES. Acute petrified myocardium associated with meningococcal sepsis in childhood-onset systemic lupus erythematous: a fatal case. Revista do Instituto de Medicina Tropical de São Paulo, v. 61, 2019. Web of Science Citations: 0.
GABRIEL F. RAMOS; VANESSA P. RIBEIRO; MARIANA P. MERCADANTE; MAIRA P. RIBEIRO; ARTUR F. DELGADO; SYLVIA C.L. FARHAT; MARTA M. LEAL; HELOISA H. MARQUES; VICENTE ODONE-FILHO; UENIS TANNURI; WERTHER B. CARVALHO; SANDRA J. GRISI; MAGDA CARNEIRO-SAMPAIO; CLOVIS A. SILVA. Mortality in adolescents and young adults with chronic diseases during 16 years: a study in a Latin American tertiary hospital. Jornal de Pediatria, v. 95, n. 6, p. 667-673, Dez. 2019. Web of Science Citations: 1.
PASOTO, SANDRA GOFINET; DE OLIVEIRA MARTINS, VICTOR ADRIANO; BONFA, ELOISA. Sjogren's syndrome and systemic lupus erythematosus: links and risks. OPEN ACCESS RHEUMATOLOGY-RESEARCH AND REVIEWS, v. 11, p. 33-45, 2019. Web of Science Citations: 4.
BALBI, VERENA A.; MONTENEGRO, BARBARA; PITTA, ANA C.; SCHMIDT, ANA R.; FARHAT, SYLVIA C.; COELHO, LAILA P.; FERREIRA, JULIANA C. O.; PEREIRA, ROSA M. R.; TERRERI, MARIA T.; SAAD-MAGALHAES, CLAUDIA; AIKAWA, NADIA E.; SAKAMOTO, ANA P.; KOZU, KATIA; CAMPOS, LUCIA M.; SALLUM, ADRIANA M.; FERRIANI, VIRGINIA P.; PIOTTO, DANIELA P.; BONFA, ELOISA; SILVA, CLOVIS A. Autoimmune hepatitis in 847 childhood- onset systemic lupus erythematosus population: a multicentric cohort study. ADVANCES IN RHEUMATOLOGY, v. 58, DEC 13 2018. Web of Science Citations: 1.
SHIMABUCO, ANDREA Y.; GONCALVES, CELIO R.; MORAES, JULIO C. B.; WAISBERG, MARIANA G.; RIBEIRO, ANA CRISTINA DE M.; SAMPAIO-BARROS, PERCIVAL D.; GOLDENSTEIN-SCHAINBERG, CLAUDIA; BONFA, ELOISA; SAAD, CARLA G. S. Factors associated with ASDAS remission in a long-term study of ankylosing spondylitis patients under tumor necrosis factor inhibitors. ADVANCES IN RHEUMATOLOGY, v. 58, DEC 4 2018. Web of Science Citations: 0.
FERREIRA, JULIANA C. O. A.; TRINDADE, VITOR C.; ESPADA, GRACIELA; MOREL, ZOILO; BONFA, ELOISA; MAGALHAES, CLAUDIA S.; SILVA, CLOVIS ARTUR. Epidemiology and management practices for childhood-onset systemic lupus erythematosus patients: a survey in Latin America. CLINICAL RHEUMATOLOGY, v. 37, n. 12, p. 3299-3307, DEC 2018. Web of Science Citations: 0.
BUSCATTI, IZABEL M.; ABRAO, HENRIQUE M.; KOZU, KATIA; MARQUES, VICTOR L. S.; GOMES, ROBERTA C.; SALLUM, ADRIANA M. E.; SILVA, CLOVIS A. Characterization of scrotal involvement in children and adolescents with IgA vasculitis. ADVANCES IN RHEUMATOLOGY, v. 58, NOV 3 2018. Web of Science Citations: 2.
HOLLAND, MICHAEL J.; BERESFORD, MICHAEL W.; FELDMAN, BRIAN M.; HUGGINS, JENNIFER; NORAMBUENA, XIMENA; SILVA, CLOVIS A.; SUSIC, GORDANA; SZTAJNBOK, FLAVIO; UZIEL, YOSEF; APPENZELLER, SIMONE; ARDOIN, STACY P.; AVCIN, TADEJ; FLORES, FRANCISCO; GOILAV, BEATRICE; KHUBCHANDANI, RAJU; KLEIN-GITELMAN, MARISSA; LEVY, DEBORAH; RAVELLI, ANGELO; WENDERFER, SCOTT E.; YING, JUN; RUPERTO, NICOLINO; BRUNNER, HERMINE I.; INVESTIGATORS, PRINTO PRCSG. Measuring Disease Damage and Its Severity in Childhood-Onset Systemic Lupus Erythematosus. ARTHRITIS CARE & RESEARCH, v. 70, n. 11, p. 1621-1629, NOV 2018. Web of Science Citations: 1.
TOMIOKA, RENATO B.; FERREIRA, GABRIELA R. V.; AIKAWA, NADIA E.; MACIEL, GUSTAVO A. R.; SERAFINI, PAULO C.; SALLUM, ADRIANA M.; CAMPOS, LUCIA M. A.; GOLDESTEIN-SCHAINBERG, CLAUDIA; BONFA, ELOISA; SILVA, CLOVIS A. Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients. CLINICAL RHEUMATOLOGY, v. 37, n. 10, p. 2869-2873, OCT 2018. Web of Science Citations: 1.
SILVA, CLOVIS A.; TERRERI, MARIA T.; BONFA, ELOISA; SAAD-MAGALHAES, CLAUDIA. Pediatric rheumatic disease patients: time to extend the age limit of adolescence?. ADVANCES IN RHEUMATOLOGY, v. 58, SEP 18 2018. Web of Science Citations: 1.
ALVENO, RENATA A.; MIRANDA, V, CAROLINE; PASSONE, CAROLINE G.; WAETGE, AURORA R.; HOJO, ELZA S.; FARHAT, SYLVIA C. L.; ODONE-FILHO, VICENTE; TANNURI, UENIS; CARVALHO, WERTHER B.; CARNEIRO-SAMPAIO, MAGDA; SILVA, CLOVIS A. Pediatric chronic patients at outpatient clinics: a study in a Latin American University Hospital. Jornal de Pediatria, v. 94, n. 5, p. 539-545, SEP-OCT 2018. Web of Science Citations: 1.
NOVAK, V, G.; MOLINARI, B. C.; FERREIRA, J. C.; SAKAMOTO, A. P.; TERRERI, M. T.; PEREIRA, R. M. R.; SAAD-MAGALHAES, C.; AIKAWA, N. E.; CAMPOS, L. M.; LEN, C. A.; APPENZELLER, S.; FERRIANI, V. P.; SILVA, M. F.; OLIVEIRA, S. K.; ISLABDO, A. G.; SZTAJNBOK, F. R.; PAIM, L. B.; BARBOSA, C. M.; SANTOS, M. C.; BICA, B. E.; SENA, E. G.; MORAES, A. J.; ROLIM, A. M.; SPELLING, P. F.; SCHEIBEL, I. M.; CAVALCANTI, A. S.; MATOS, E. N.; ROBAZZI, T. C.; GUIMARACS, L. J.; SANTOS, F. P.; SILVA, C. T.; BONFA, E.; SILVA, C. A.; SYSTEMIC, BRAZILIAN CHILDHOOD-ONSET. Characteristics of 1555 childhood-onset lupus in three groups based on distinct time intervals to disease diagnosis: a Brazilian multicenter study. Lupus, v. 27, n. 10, p. 1712-1717, SEP 2018. Web of Science Citations: 2.
SETOUE, DEBORA N.; PITTA, ANA C.; FIOROT, FERNANDA J.; NASTRI, MARIANA M.; NOVAK, GLAUCIA V.; MOLINARI, BEATRIZ C.; OLIVEIRA, JULIANA C.; GORMEZANO, NATALI W.; SAKAMOTO, ANA P.; TERRERI, MARIA T.; PEREIRA, ROSA M.; SAAD-MAGALHAES, CLAUDIA; SALLUM, ADRIANA M.; KOZU, KATIA; FRAGA, MELISSA M.; PIOTTO, DANIELA P.; CLEMENTE, GLEICE; MARINI, ROBERTO; GOMES, HUGO R.; RABELO-JUNIOR, CARLOS N.; FELIX, MARTA M.; RIBEIRO, MARIA C.; ALMEIDA, ROZANA G.; ASSAD, ANA P.; SACCHETTI, SILVANA B.; BARROS, LEANDRA C.; BONFA, ELOISA; SILVA, CLOVIS A.; SYSTEMIC, BRAZILIAN CHILDHOOD-ONSET. Symptomatic polyautoimmunity at diagnosis of 1463 childhood-onset lupus: A Brazilian multicenter study. AUTOIMMUNITY REVIEWS, v. 17, n. 8, p. 836-839, AUG 2018. Web of Science Citations: 3.
BRUNNER, HERMINE I.; HOLLAND, MICHAEL; BERESFORD, MICHAEL W.; ARDOIN, STACY P.; APPENZELLER, SIMONE; SILVA, CLOVIS A.; FLORES, FRANCISCO; GOILAV, BEATRICE; WENDERFER, SCOTT E.; LEVY, DEBORAH M.; RAVELLI, ANGELO; KHUNCHANDANI, RAJU; AVCIN, TADEJ; KLEIN-GITELMAN, MARISA S.; FELDMAN, BRIAN M.; RUPERTO, NICOLINO; YING, JUN; INVESTIGATORS, PRCSG PRINTO. American College of Rheumatology Provisional Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus. ARTHRITIS CARE & RESEARCH, v. 70, n. 6, p. 813-822, JUN 2018. Web of Science Citations: 4.
BUSCATTI, IZABEL M.; CASELLA, BEATRIZ B.; AIKAWA, NADIA E.; WATANABE, ANDREA; FARHAT, SYLVIA C. L.; CAMPOS, LUCIA M. A.; SILVA, CLOVIS ARTUR. Henoch-Schonlein purpura nephritis: initial risk factors and outcomes in a Latin American tertiary center. CLINICAL RHEUMATOLOGY, v. 37, n. 5, p. 1319-1324, MAY 2018. Web of Science Citations: 7.
BENATTI, FABIANA B.; MIYAKE, CINTIA N. H.; DANTAS, WAGNER S.; ZAMBELLI, VANESSA O.; SHINJO, SAMUEL K.; PEREIRA, ROSA M. R.; SILVA, MARIA ELIZABETH R.; SA-PINTO, ANA LUCIA; BORBA, EDUARDO; BONFA, ELOISA; GUALANO, BRUNO. Exercise Increases Insulin Sensitivity and Skeletal Muscle AMPK Expression in Systemic Lupus Erythematosus: A Randomized Controlled Trial. FRONTIERS IN IMMUNOLOGY, v. 9, APR 27 2018. Web of Science Citations: 3.
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