| Grant number: | 13/04806-0 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | July 01, 2013 |
| End date: | June 30, 2017 |
| Field of knowledge: | Health Sciences - Physical Education |
| Principal Investigator: | Antonio Herbert Lancha Junior |
| Grantee: | Vitor de Salles Painelli |
| Host Institution: | Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract Carnosine is a cytoplasmic dipeptide found in abundance in skeletal muscle. The pH buffering is the best function attributed to carnosine. Cross-sectional studies have shown that athletes engaged in high-intensity, short duration exercises have a higher muscle carnosine content compared to untrained and physically active subjects, supporting the role of carnosine as a buffer, and suggesting that exercise training could modulate the dipeptide intramuscular concentrations. However, the longitudinal studies investigating the effect of exercise training on muscle carnosine content did not observe any effects of this intervention. It is speculated that the lack of dietary control, as well as the use of low intensity and/or duration exercise protocols are potential causes for the lack of effect of exercise training on intramuscular carnosine. Therefore, our group aims to investigate the effects of 12 weeks of high-intensity intermittent training on intramuscular carnosine concentrations. For this purpose, approximately 20 vegetarians volunteers will be recruited, matched for maximal aerobic capacity (VO2máx) and randomly assigned to the Trained (T - n = 10) or Non-Trained (NT - n = 10) group. Before (PRE) and after (POST) the training period, volunteers will undergo a muscle biopsy procedure of the vastus lateralis to assess the intramuscular content of carnosine. Additionally, at PRE and POST volunteers will also undergo a cardiopulmonary exercise test for assessment of physical capacity and VO2máx. Furthermore, they will also be submitted to an assessment of body composition by hydrostatic weighing. The inferential analysis will be conducted by independent T-test and analysis of variance for mixed model with SAS. The level of significance will be p <0.05. (AU) | |
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