Incorporation of polygodial in Langmuir films of selected lipids

Author(s)

Goncalves, Giulia Elisa G. ^[1] ; Morais, Thiago R. ^[1] ; Lago, Joao Henrique G. ^[2] ; Caseli, Luciano ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Chem, Diadema, SP - Brazil

^[2] Fed Univ ABC, Ctr Nat & Human Sci, BR-09210580 Santo Andre - Brazil

• Document type: Journal article
• Source: Thin Solid Films; v. 669, p. 19-28, JAN 1 2019.
• Web of Science Citations: 0

Abstract

Identification of membrane sites capable of drug binding is important to understand the interaction of bioactive compounds with biointerfaces such as microbial cellular membranes. As the exact molecular mechanism of action is yet to be fully understood for many drugs, in this study, polygodial, an antimicrobial compound, was incorporated in Langmuir monolayers of selected lipids that served as cell membrane models. Results from pressure-area isotherms, specific vibrational spectroscopy and Brewster angle microscopy revealed the expansion of the lipid monolayers, but with distinctive effects for each lipid in terms of film compressibility, stability, order of alkyl chains, and topographical morphology. These data can be therefore correlated with the possible bioactivity effect of polygodial in lipidic surfaces of mammalian and microbial membranes. (AU)

• FAPESP's process: 15/23446-0 - Smart surfaces: nanostructured and bioinspired systems for the investigation of molecular interactions in membrane models and for the production of devices for biosensors and environmental analysis
• Grantee: Luciano Caseli
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/07885-1 - Biomolecules from plant species of remnant areas of the Atlantic Forest and Cerrado to treat neglected tropical diseases - chemical and pharmacological aspects
• Grantee: João Henrique Ghilardi Lago
• Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants