Antiproliferative effects and main molecular mechanisms of Brazilian native fruits and their by-products on lung cancer

Author(s)

Machado, Ana Paula da Fonseca ; Alves, Mariana da Rocha ; Nascimento, Roberto de Paula do ; Reguengo, Livia Mateus ; Marostica Jr, Mario Roberto

• Document type: Journal article
• Source: Food Research International; v. 162, p. 9-pg., 2022-12-01.

Abstract

Lung Cancer (LC) is an emergent disease widespread globally. Compared to other types of cancer, LC has one of the lowest survival rates (18%). As some risk factors associated with the development of lung carcinogenesis are still unavoidable, researchers have been trying to find efficient and safe alternatives that can help prevent LC or even attenuate its rapid evolution after diagnosis. Studies with natural products promise to offer biological effects against several types of cancers, including LC. The uncountable types of plant matrices dispersed in nature, or even their extracts, contain a powerful composition of bioactive compounds with promising biological effects on LC. The biomes in Brazil are examples of regions with a great biodiversity of bioactive compounds-rich fruits. Therefore, this review aimed to present the potential anticancer effect of Brazilian native fruits, their fractions, and by-products on LC through the elucidation of the main molecular mechanisms involved. The Brazilian plant matrices discussed here (acai, achiote, araticum, camu camu, cocoa, jaboticaba, genipap, guarana, and pequi) showed promising evidence by inducing cellular apoptosis, reducing cancer cell viability and tumor growth, and regulating cell cycle. (AU)

• FAPESP's process: 17/23657-6 - Development of microparticles containing grape skin extract through the emerging technique SAS and evaluation of their antioxidant and anti-inflammatory effects in the treatment of induced Colitis in rats
• Grantee: Ana Paula da Fonseca Machado
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/03228-9 - Preventive effects of the consumption of freeze-dried jaboticaba peel in BALB/c mice with Colorectal Cancer induced by azoxymethane/dextran sodium sulfate
• Grantee: Roberto de Paula do Nascimento
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
• Grantee: Glaucia Maria Pastore
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/12244-8 - Effect of jabuticaba (Plinia jaboticaba) peel supplementation on metabolic profile in obese pre-diabetic subjects: a randomized, double-blinded, controlled trial
• Grantee: Marina Vilar Geraldi
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants