Early childhood interventions and trajectories of cognitive, social and emotional development

• Grant number: 16/22455-8
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2018
• End date: March 31, 2024
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Guilherme Vanoni Polanczyk
• Grantee: Guilherme Vanoni Polanczyk
• Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais: Alicia Matijasevich Manitto
• Associated researchers: Alexandre Archanjo Ferraro ; Anna Maria Chiesa ; Eliane Correa Miotto ; Eurípedes Constantino Miguel Filho ; Helena Paula Brentani ; Kette Dualibi Ramos Valente ; Lislaine Aparecida Fracolli ; Luis Augusto Paim Rohde ; Marina Leite Puglisi
• Associated research grant(s): 18/17225-9 - Multi-user equipment approved in grant 2016/22455-8: EEG system 128 channel, AP.EMU
• Associated scholarship(s): 22/10629-2 - Assessment of the impact of the SARS-CoV-2 pandemic on child cognitive development, BP.IC; 22/06817-8 - The impact of climate change on the mental health of children and adolescents: a systematic review, BP.IC; 21/12439-3 - Exploring digital phenotypes associated with depression and anxiety using smartphone sensors in randomized clinical trials, BP.PD; + associated scholarships 21/08540-0 - Evaluation of the effects of treatment with methylphenidate compared with parental training in preschool children with ADHD on the path of cognitive, social, emotional and psychopathological development, BP.DD; 19/07422-4 - The effect of an intervention program over the maternal reflective ability, emotional availability and stress level, BP.PD; 19/00351-4 - Trajectories of symptoms of inattention, hyperactivity and impulsivity over a treatment for Attention Deficit Hyperactivity Disorder, BP.IC; 16/13451-9 - Developing ecological and frequent measures of cognitive and psychosocial stimulation in childhood in the context of a home visitation program for pregnant youth, BP.PD - associated scholarships

Abstract

The main objective of this thematic project is to deepen the knowledge on early childhood interventions and their effects on the trajectories of cognitive, social and emotional development until the school age. Special emphasis is given to the emergence of mental disorders as the primary phenotypic outcome. Therefore, we will test three early childhood intervention programs with different characteristics: a preschool curriculum to promote socio-emotional skills and to prevent behavioral problems, a home visitation program for pregnant adolescents highly vulnerable and their children during the first two years of life in order to develop parenting skills, and two therapeutic modalities for early intervention of attention-deficit/hyperactivity disorder. We will investigate the effects of the programs over underlying biological measures of developmental trajectories, specifically electrophysiological patterns, brain structure, and activity. Thus, we will generate new data on how early childhood intervention programs impact the cognitive, social and emotional development and what are its effects on the prevention of mental disorders throughout childhood. Through these objectives, we will consolidate a platform for conducting randomized controlled trials in childhood mental health in our country and establish a developmental neuroscience laboratory to characterize the trajectory of brain development and the effects of early childhood interventions. (AU)

Scientific publications

(26)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JORDANA VERANO DE OLIVEIRA; DANIEL FATORI; ELIZABETH SHEPHARD; MAURO XAVIER NETO; ALICIA MATIJASEVICH; ALEXANDRE ARCHANJO FERRARO; LUIS AUGUSTO ROHDE; ANNA MARIA CHIESA; EURIPEDES CONSTANTINO MIGUEL; GUILHERME V. POLANCZYK. Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life. Revista Brasileira de Psiquiatria, 2022-06-24. (16/22455-8)

SUGAYA, LUISA SHIGUEMI; KIRCANSKI, KATHARINA; STRINGARIS, ARGYRIS; POLANCZYK, GUILHERME V.; LEIBENLUFT, ELLEN. Validation of an irritability measure in preschoolers in school-based and clinical Brazilian samples. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, JAN 2021. (16/22455-8)

FARHAT, LUIS C.; BRENTANI, HELENA; DE TOLEDO, VICTOR HUGO CALEGARI; SHEPHARD, ELIZABETH; MATTOS, PAULO; BARON-COHEN, SIMON; THAPAR, ANITA; CASELLA, ERASMO; POLANCZYK, GUILHERME V.. DHD and autism symptoms in youth: a network analysi. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, v. 63, n. 2, p. 143-151, FEB 2022. (16/22455-8, 18/22396-7, 19/27680-8)

SHEPHARD, ELIZABETH; FATORI, DANIEL; MAURO, LARISSA REZENDE; DE MEDEIROS FILHO, V, MAURO; HOEXTER, MARCELO Q.; CHIESA, ANNA M.; FRACOLLI, LISLAINE A.; BRENTANI, HELENA; FERRARO, ALEXANDRE A.; NELSON, III, CHARLES A.; et al. Effects of Maternal Psychopathology and Education Level on Neurocognitive Development in Infants of Adolescent Mothers Living in Poverty in Brazil. BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING, v. 4, n. 10, p. 925-934, OCT 2019. (16/22455-8, 17/17718-2)

SHEPHARD, ELIZABETH; ZUCCOLO, PEDRO F.; IDREES, IMAN; GODOY, PRISCILLA B. G.; SALOMONE, ERICA; FERRANTE, CAMILLA; SORGATO, PAOLA; CATAO, LUIS F. C. C.; GOODWIN, AMY; BOLTON, PATRICK F.; et al. Systematic Review and Meta-analysis: The Science of Early-Life Precursors and Interventions for Attention-Deficit/Hyperactivity Disorder. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, v. 61, n. 2, p. 187-226, FEB 2022. (16/22455-8, 18/22396-7, 19/24819-5)

EUCLYDES, VERONICA; BRAGA, CAIO I. S.; GOUVEIA, GISELE; MARTINEZ, RAQUEL C. R.; CAMILO, CAROLINE; SIMOES, SERGIO N.; MARTINS-JR, DAVID C.; FRACOLLI, LISLAINE; ARGEU, ADRIANA; FERRARO, ALEXANDRE; et al. Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach. BRAIN, BEHAVIOR, & IMMUNITY - HEALTH, v. 40, p. 11-pg., 2024-08-05. (18/18560-6, 20/16376-3, 23/01343-0, 16/22455-8, 18/21934-5, 20/15590-1, 21/00485-0)

WILEY, KYLE S.; CAMILO, CAROLINE; GOUVEIA, GISELE; EUCLYDES, VERONICA; PANTER-BRICK, CATHERINE; MATIJASEVICH, ALICIA; FERRARO, ALEXANDRE ARCHANJO; FRACOLLI, LISLAINE APARECIDA; CHIESA, ANNA MARIA; MIGUEL, EURIPEDES CONSTANTINO; et al. Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother-infant pairs. DEVELOPMENTAL PSYCHOBIOLOGY, v. 65, n. 1, p. 16-pg., 2023-01-01. (16/22455-8, 18/18560-6)

FATORI, DANIEL; ZUCCOLO, PEDRO FONSECA; POLANCZYK, GUILHERME V.. A global challenge: maternal depression and offspring mental disorders. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 29, n. 5, p. 3-pg., 2020-05-08. (16/13451-9, 16/22455-8)

FARHAT, LUIS C.; BRENTANI, HELENA; POLANCZYK, GUILHERME V.. Editorial: Polygenic Risk as a Biomarker for Attention-Deficit/Hyperactivity Disorder. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, v. 59, n. 8, p. 3-pg., 2020-08-01. (16/22455-8)

POLANCZYK, GUILHERME V.. Building the Evidence to Treat Preschoolers With ADHD in Real-Life Settings. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, v. 57, n. 8, p. 3-pg., 2018-08-01. (16/22455-8)

RIBEIRO, TATIANE CRISTINA; FARHAT, LUIS C.; CASELLA, ERASMO B.; GRAEFF-MARTINS, ANA SOLEDADE; BARON-COHEN, SIMON; ALLISON, CARRIE; POLANCZYK, GUILHERME, V. Brazilian Portuguese Childhood Autism Spectrum Test an investigation of the factor structure of autistic traits in school-aged children. Revista Brasileira de Psiquiatria, v. 44, n. 6, p. 5-pg., 2022-11-01. (21/08540-0, 16/22455-8)

PEREIRA ALARCAO, FERNANDA SPEGGIORIN; SHEPHARD, ELIZABETH; FATORI, DANIEL; AMAVEL, RENATA; CHIESA, ANNA; FRACOLLI, LISLAINE; MATIJASEVICH, ALICIA; BRENTANI, HELENA; NELSON, CHARLES A.; LECKMAN, JAMES; et al. Promoting mother-infant relationships and underlying neural correlates: Results from a randomized controlled trial of a home-visiting program for adolescent mothers in Brazil. DEVELOPMENTAL SCIENCE, APR 2021. (16/22455-8, 18/22396-7, 14/50917-0)

AGNEW-BLAIS, JESSICA C.; WERTZ, JASMIN; ARSENEAULT, LOUISE; BELSKY, DANIEL W.; DANESE, ANDREA; PINGAULT, JEAN-BAPTISTE; POLANCZYK, GUILHERME, V; SUGDEN, KAREN; WILLIAMS, BENJAMIN; MOFFITT, TERRIE E.. Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, v. 63, n. 10, p. 11-pg., 2022-07-14. (16/22455-8)

SUGAYA, LUISA SHIGUEMI; KIRCANSKI, KATHARINA; STRINGARIS, ARGYRIS; POLANCZYK, GUILHERME V.; LEIBENLUFT, ELLEN. Validation of an irritability measure in preschoolers in school-based and clinical Brazilian samples. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 31, n. 4, p. 11-pg., 2021-01-02. (16/22455-8)

ZUCCOLO, PEDRO FONSECA; CASELLA, CAIO BORBA; FATORI, DANIEL; SHEPHARD, ELIZABETH; SUGAYA, LUISA; GURGEL, WAGNER; FARHAT, LUIS CARLOS; ARGEU, ADRIANA; TEIXEIRA, MONIKE; OTOCH, LUARA; et al. Children and adolescents' emotional problems during the COVID-19 pandemic in Brazil. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. N/A, p. 13-pg., 2022-05-27. (16/22455-8)

FATORI, DANIEL; ZUCCOLO, PEDRO FONSECA; SHEPHARD, ELIZABETH; BRENTANI, HELENA; MATIJASEVICH, ALICIA; ARCHANJO FERRARO, ALEXANDRE; APARECIDA FRACOLLI, LISLAINE; CHIESA, ANNA MARIA; LECKMAN, JAMES; CONSTANTINO MIGUEL, EURIPEDES; et al. A randomized controlled trial testing the efficacy of a Nurse Home Visiting Program for Pregnant Adolescents. SCIENTIFIC REPORTS, v. 11, n. 1, JUL 13 2021. (16/13451-9, 16/22455-8, 18/22396-7)

PEREIRA ALARCAO, FERNANDA SPEGGIORIN; SHEPHARD, ELIZABETH; FATORI, DANIEL; AMAVEL, RENATA; CHIESA, ANNA; FRACOLLI, LISLAINE; MATIJASEVICH, ALICIA; BRENTANI, HELENA; NELSON, CHARLES A.; LECKMAN, JAMES; et al. Promoting mother-infant relationships and underlying neural correlates: Results from a randomized controlled trial of a home-visiting program for adolescent mothers in Brazil. DEVELOPMENTAL SCIENCE, v. 24, n. 6, NOV 2021. (14/50917-0, 18/22396-7, 16/22455-8)

GODOY, PRISCILLA B. G.; SHEPHARD, ELIZABETH; ARGEU, ADRIANA; SILVEIRA, LETICIA R.; SALOMONE, ERICA; ALDRED, CATHERINE; GREEN, JONATHAN; POLANCZYK, GUILHERME, V; MATIJASEVICH, ALICIA. Social communication therapy for children at risk for neurodevelopmental difficulties: Protocol for a clinical trial. Annals of the New York Academy of Sciences, v. 1514, n. 1, p. 12-pg., 2022-05-04. (16/22455-8)

BUITELAAR, JAN; BOLTE, SVEN; BRANDEIS, DANIEL; CAYE, ARTHUR; CHRISTMANN, NINA; CORTESE, SAMUELE; COGHILL, DAVID; FARAONE, STEPHEN V.; FRANKE, BARBARA; GLEITZ, MARKUS; et al. Toward Precision Medicine in ADHD. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 16, p. 25-pg., 2022-07-06. (16/22455-8)

JORDANA VERANO DE OLIVEIRA; DANIEL FATORI; ELIZABETH SHEPHARD; MAURO XAVIER NETO; ALICIA MATIJASEVICH; ALEXANDRE ARCHANJO FERRARO; LUIS AUGUSTO ROHDE; ANNA MARIA CHIESA; EURIPEDES CONSTANTINO MIGUEL; GUILHERME V. POLANCZYK. Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life. Revista Brasileira de Psiquiatria, v. 44, n. 4, p. 388-400, 2022-06-24. (16/22455-8)

TATIANE CRISTINA RIBEIRO; LUIS C. FARHAT; ERASMO B. CASELLA; ANA SOLEDADE GRAEFF-MARTINS; SIMON BARON-COHEN; CARRIE ALLISON; GUILHERME V. POLANCZYK. Brazilian Portuguese Childhood Autism Spectrum Test: an investigation of the factor structure of autistic traits in school-aged children. Revista Brasileira de Psiquiatria, 2022-10-24. (21/08540-0, 16/22455-8)

GURGEL, WAGNER; GARCIA-ARGIBAY, MIGUEL; D'ONOFRIO, BRIAN M.; LARSSON, HENRIK; POLANCZYK, GUILHERME V.. Predictors of preschool attention-deficit/hyperactivity disorder diagnosis: a population-based study using national registers. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, v. N/A, p. 12-pg., 2024-12-15. (16/22455-8)

OLFSON, EMILY; FARHAT, LUIS C.; LIU, WENZHONG; VITULANO, LAWRENCE A.; ZAI, GWYNETH; LIMA, MONICKE O.; PARENT, JUSTIN; POLANCZYK, GUILHERME V.; CAPPI, CAROLINA; KENNEDY, JAMES L.; et al. Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes. NATURE COMMUNICATIONS, v. 15, n. 1, p. 10-pg., 2024-07-12. (16/22455-8)

FARAONE, STEPHEN V.; BELLGROVE, MARK A.; BRIKELL, ISABELL; CORTESE, SAMUELE; HARTMAN, CATHARINA A.; HOLLIS, CHRIS; NEWCORN, JEFFREY H.; PHILIPSEN, ALEXANDRA; POLANCZYK, GUILHERME V.; RUBIA, KATYA; et al. Attention-deficit/hyperactivity disorder. NATURE REVIEWS DISEASE PRIMERS, v. 10, n. 1, p. 21-pg., 2024-02-22. (16/22455-8)

FARHAT, LUIS C.; BLAKEY, RACHEL; SMITH, GEORGE DAVEY; FUJITA, ANDRE; SHEPHARD, ELIZABETH; STERGIAKOULI, EVIE; ELEY, THALIA C.; THAPAR, ANITA; POLANCZYK, GUILHERME V.. Networks of Neurodevelopmental Traits, Socioenvironmental Factors, Emotional Dysregulation in Childhood, and Depressive Symptoms Across Development in Two UK Cohorts. American Journal of Psychiatry, v. 180, n. 10, p. 11-pg., 2023-10-01. (16/22455-8, 21/08540-0, 20/05964-1)

FATORI, DANIEL; POLANCZYK, GUILHERME V.. The role of digital technology in bridging the child mental health care gap. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, v. 28, n. 4, p. 2-pg., 2019-04-01. (16/13451-9, 16/22455-8)