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Separation of bioactive compounds from black tea and mate by on-line coupling of pressurized liquid extraction with an adsorbent and evaluation of their antimicrobial potential

Grant number: 18/17089-8
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2019
Effective date (End): May 31, 2022
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal researcher:Maurício Ariel Rostagno
Grantee:Mariana Corrêa de Souza
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Associated scholarship(s):19/18772-6 - Development of fast methods for analysis and characterization chemical profile of compounds in black tea and mate leaves, BE.EP.DD


Tea is one of the most consumed beverages in the world, being considered one of the oldest drinks produced by biotechnology developed by the human being. Its use occurs in the form of infusions and its ample consumption is related to its sensorial and stimulating properties. The chemical composition of the leaves of black tea (Camellia sinensis) and mate (Ilex paraguariensis) is quite diverse with the presence of a wide variety of components. Black tea (Camellia sinensis) has high concentrations of compounds that have antimicrobial properties, as well as the herb mate (Ilex paraguariensis), and can be exploited for the use of preservatives in foods, for example. In order to use these natural products it is necessary to carry out an extraction process to remove the biologically active compounds from the raw material matrix and for this different techniques and extraction methods can be used. These extraction techniques range from the simplest, such as maceration, to advanced processes such as pressurized liquids (PLE). Conventional methods of extraction have disadvantages, such as low selectivity, low concentration of compounds of interest, delay in extraction time and high solvent consumption to obtain the compounds. In contrast, modern extraction techniques allow the process to be carried out more quickly with lower solvent consumption and extracts with higher concentration and less contaminants. The aim of this work is to study the combination of pressurized fluid extraction and solid phase extraction for the purification of phenolic compounds from black and matte tea, as well as to evaluate the antimicrobial potential of the flavonoid fraction and its use against pathogenic and deteriorating microorganisms. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TAMBORLIN, LETICIA; SUMERE, BEATRIZ ROCCHETTI; DE SOUZA, MARIANA CORREA; PESTANA, NATHALIE FORTES; AGUIAR, ANA CAROLINA; EBERLIN, MARCOS NOGUEIRA; SIMABUCO, FERNANDO MOREIRA; ROSTAGNO, MAURICIO ARIEL; LUCHESSI, AUGUSTO DUCATI. Characterization of pomegranate peel extracts obtained using different solvents and their effects on cell cycle and apoptosis in leukemia cells. FOOD SCIENCE & NUTRITION, v. 8, n. 10, . (18/17089-8, 15/18119-0, 19/06951-3, 10/18095-0, 18/14818-9, 17/21914-1, 13/04304-4)
DA SILVA, LAISE C.; VIGANO, JULIANE; DE SOUZA MESQUITA, LEONARDO M.; BAIAO DIAS, ARTHUR L.; DE SOUZA, MARIANA C.; SANCHES, VITOR L.; CHAVES, JAISA O.; PIZANI, RODRIGO S.; CONTIERI, LETICIA S.; ROSTAGNO, MAURICIO A.. Recent advances and trends in extraction techniques to recover polyphenols compounds from apple by-products. FOOD CHEMISTRY-X, v. 12, . (20/08421-9, 20/03623-2, 19/24537-0, 20/15774-5, 19/18772-6, 19/13496-0, 18/17089-8, 20/04067-6, 18/14582-5)
VIGANO, JULIANE; SANCHES, VITOR L.; MESQUITA, LEONARDO M. DE SOUZA; DE SOUZA, MARIANA C.; DA SILVA, LAISE C.; CHAVES, JAISA O.; FORSTER-CARNEIRO, TANIA; ROSTAGNO, MAURICIO A.. Comprehensive analysis of phenolic compounds from natural products: Integrating sample preparation and analysis. Analytica Chimica Acta, v. 1178, . (19/24537-0, 18/14582-5, 19/18772-6, 20/08421-9, 18/17089-8, 13/04304-4, 18/14938-4, 20/15774-5)
DA SILVA, LAISE C.; SOUZA, MARIANA C.; SUMERE, BEATRIZ R.; SILVA, LUIZ G. S.; DA CUNHA, DIOGO T.; BARBERO, GERARDO F.; BEZERRA, ROSANGELA M. N.; ROSTAGNO, MAURICIO A.. Simultaneous extraction and separation of bioactive compounds from apple pomace using pressurized liquids coupled on-line with solid-phase extraction. Food Chemistry, v. 318, . (18/14582-5, 16/19930-6, 18/17089-8, 19/24537-0)
SILVA, CAMILA TELLES; DA SOUZA, MARIANA CORREA; DA FONSECA MACHADO, ANA PAULA; DO NASCIMENTO, ROBERTO DE PAULA; DA CUNHA, DIOGO THIMOTEO; NEVES BEZERRA, ROSANGELA MARIA; ROSTAGNO, MAURICIO ARIEL. Thermal stability and sensory evaluation of a bioactive extract from roasted coffee (Coffea arabica) beans added at increasing concentrations to conventional bread. JOURNAL OF FOOD PROCESSING AND PRESERVATION, v. 45, n. 11, . (18/14582-5, 16/19930-6, 17/23657-6, 13/04304-4, 18/17089-8)
SOUZA, MARIANA C.; SANTOS, MARIANA P.; SUMERE, BEATRIZ R.; SILVA, LAISE C.; CUNHA, DIOGO T.; MARTINEZ, JULIAN; BARBERO, GERARDO F.; ROSTAGNO, MAURICIO A.. Isolation of gallic acid, caffeine and flavonols from black tea by on-line coupling of pressurized liquid extraction with an adsorbent for the production of functional bakery products. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 117, . (16/20016-7, 16/19930-6, 18/17089-8)
PENA, FABIOLA L.; SOUZA, MARIANA C.; VALLE, MARIA CAROLINA P. R.; BEZERRA, ROSANGELA M. N.; ROSTAGNO, MAURICIO A.; ANTUNES, ADRIANE E. C.. Probiotic fermented milk with high content of polyphenols: Study of viability and bioaccessibility after simulated digestion. INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY, v. 74, n. 1, . (16/19930-6, 15/07299-7, 18/17089-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, Mariana Corrêa de. Extracción y purificación en línea y análisis de compuestos bioactivos del té negro (Camellia sinensis) y mate (Ilex paraguariensis): aplicación en alimentos y evaluación del potencial biológico. 2022. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.

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