| Full text | |
| Author(s): Show less - |
Candido, Darlan S.
[1, 2]
;
Claro, Ingra M.
[2, 3]
;
de Jesus, Jaqueline G.
[2, 3]
;
Souza, William M.
[4]
;
Moreira, Filipe R. R.
[5]
;
Dellicour, Simon
[6, 7]
;
Mellan, Thomas A.
[8]
;
du Plessis, Louis
[1]
;
Pereira, Rafael H. M.
[9]
;
Sales, Flavia C. S.
[2, 3]
;
Manuli, Erika R.
[2, 3]
;
Theze, Julien
[10]
;
Almeida, Luiz
[11]
;
Menezes, Mariane T.
[5]
;
Voloch, Carolina M.
[5]
;
Fumagalli, Marcilio J.
[4]
;
Coletti, Thais M.
[2, 3]
;
Silva, Camila A. M.
[2, 3]
;
Ramundo, Mariana S.
[2, 3]
;
Amorim, Mariene R.
[12]
;
Hoeltgebaum, Henrique H.
[13]
;
Mishra, Swapnil
[8]
;
Gill, Mandev S.
[7]
;
Carvalho, Luiz M.
[14]
;
Buss, Lewis F.
[2]
;
Prete Jr, Carlos A.
;
Ashworth, Jordan
[15]
;
Nakaya, I, Helder
;
Peixoto, Pedro S.
[16]
;
Brady, Oliver J.
[17, 18]
;
Nicholls, Samuel M.
[19]
;
Tanuri, Amilcar
[5]
;
Rossi, Atila D.
[5]
;
Braga, V, Carlos K.
;
Gerber, Alexandra L.
[11]
;
Guimaraes, Ana Paula de C.
[11]
;
Gaburo Jr, Nelson
;
Alencar, Cecila Salete
[20]
;
Ferreira, Alessandro C. S.
[21]
;
Lima, Cristiano X.
[22, 23]
;
Levi, Jose Eduardo
[24]
;
Granato, Celso
[25]
;
Ferreira, Giulia M.
[26]
;
Francisco Jr, Ronaldo S.
;
Granja, Fabiana
[12, 27]
;
Garcia, Marcia T.
[28]
;
Moretti, Maria Luiza
[28]
;
Perroud Jr, Mauricio W.
;
Castineiras, Terezinha M. P. P.
[29]
;
Lazari, Carolina S.
[30]
;
Hill, Sarah C.
[1, 31]
;
de Souza Santos, Andreza Aruska
[32]
;
Simeoni, Camila L.
[12]
;
Forato, Julia
[12]
;
Sposito, Andrei C.
[33]
;
Schreiber, Angelica Z.
[34]
;
Santos, Magnun N. N.
[34]
;
de Sa, Camila Zolini
[35]
;
Souza, Renan P.
[35]
;
Resende-Moreira, Luciana C.
[36]
;
Teixeira, Mauro M.
[37]
;
Hubner, Josy
[38]
;
Leme, Patricia A. F.
[39]
;
Moreira, Rennan G.
[40]
;
Nogueira, Mauricio L.
[41]
;
Ferguson, Neil M.
[8]
;
Costa, Silvia F.
[2, 3]
;
Proenca-Modena, Jose Luiz
[12]
;
Vasconcelos, Ana Tereza R.
[42]
;
Bhatt, Samir
[8]
;
Lemey, Philippe
[7]
;
Wu, Chieh-Hsi
[43]
;
Rambaut, Andrew
[44]
;
Loman, Nick J.
[19]
;
Aguiar, Renato S.
[35]
;
Pybus, Oliver G.
[1]
;
Sabino, Ester C.
[3]
;
Faria, Nuno Rodrigues
[2, 8]
;
Discovery, Brazil-UK Ctr Arbovirus
Total Authors: 79
|
| Affiliation: Show less - | [1] Univ Oxford, Dept Zool, Oxford - England
[2] Univ Sao Paulo, Fac Med, Inst Med Trop, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Dept Molestias Infecciosas & Parasitaries, Sao Paulo - Brazil
[4] Fac Med Ribeirao Preto, Ctr Pesquisa Virol, Ribeirao Preto - Brazil
[5] Univ Fed Rio de Janeiro, Dept Genet, Inst Biol, Rio De Janeiro - Brazil
[6] Univ Libre Bruxelles, Spatial Epidemiol Lab, Brussels - Belgium
[7] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Rega Inst, Leuven - Belgium
[8] Imperial Coll London, MRC Ctr Global Infect Dis Anal, J IDEA, London - England
[9] V, Inst Appl Econ Res, Brasilia, DF - Brazil
[10] Univ Clermont Auvergne, VetAgro Sup, INRAE, UMR EPIA, St Genes Champanelle - France
[11] Lab Bioinformat, Lab Natl Comp Cient, Petropolis - Brazil
[12] Univ Estadual Campinas, Dept Genet Evolucao Microbiol & Imunol, Inst Biol, Campinas - Brazil
[13] Imperial Coll London, Dept Math, London - England
[14] Fundacao Getalio Vargas, Escola Matemat Aplicada EMAp, Rio De Janeiro - Brazil
[15] Univ Edinburgh, Usher Inst, Edinburgh, Midlothian - Scotland
[16] Univ Sao Paulo, Inst Matemat & Estat, Dept Matemat Aplicada, Sao Paulo - Brazil
[17] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, Fac Epidemiol & Populat Hlth, London - England
[18] London Sch Hyg & Trop Med, Ctr Math Modelling Infect Dis, London - England
[19] Univ Birmingham, Inst Microbiol & Infect, Birmingham, W Midlands - England
[20] Univ Sao Paulo, LIM Lab Med Lab 03, Hosp Clin, Fac Med, Sao Paulo - Brazil
[21] Inst Hermes Pardini, Belo Horizonte, MG - Brazil
[22] Univ Fed Minas Gerais, Fac Med, Dept Cirurgia, Belo Horizonte, MG - Brazil
[23] Simile Inst Imunol Aplicada Ltda, Belo Horizonte, MG - Brazil
[24] Lab DASA, Sao Paulo - Brazil
[25] Lab Fleury, Sao Paulo - Brazil
[26] Univ Fed Uberlandia, Inst Glandes Biomed, Lab Virol, Uberlandia, MG - Brazil
[27] Univ Fed Roraima, Ctr Estudos Biodiversidade, Boa Vista, Parana - Brazil
[28] Univ Estadual Campinas, Fac Ciencias Med, Div Doences Infecciacas, Campinas, SP - Brazil
[29] Univ Fed Rio de Janeiro, Fac Med, Dept Doencas Infeccioses & Parasitarias, Rio De Janeiro - Brazil
[30] Univ Sao Paulo, Cent Hosp Clin, Fac Med, Div Lab, Sao Paulo - Brazil
[31] Royal Vet Coll, Dept Pathobiol & Populat Sci, Hatfield, Herts - England
[32] Univ Oxford, Latin Amer Ctr, Oxford Sch Global & Area Studies, Oxford - England
[33] Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med, Campinas, SP - Brazil
[34] Univ Estadual Campinas, Dept Patol, Fac Ciencias Med, Campinas, SP - Brazil
[35] Univ Fed Minas Gerais, Dept Genet Ecol & Evolucao, Inst Ciencias Biol, Belo Horizonte, MG - Brazil
[36] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bot, Belo Horizonte, MG - Brazil
[37] Univ Fed Minas Gerais, Dept Bioquim & Imunol, Belo Horizonte, MG - Brazil
[38] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Celular, Belo Horizonte, MG - Brazil
[39] Univ Estadual Campinas, Ctr Saude Comunidade, Campinas, SP - Brazil
[40] Univ Fed Minas Gerais, Ctr Labs Multiusuarios, Inst Ciencias Biol, Belo Horizonte, MG - Brazil
[41] Fac Med Sao Jose do Rio Preto, Lab Pesquisas Virol, Sao Jose Do Rio Preto, SP - Brazil
[42] Francisco Jr, Jr., Ronaldo S., Lab Bioinformat, Lab Natl Comp Cient, Petropolis - Brazil
[43] Univ Southampton, Math Sci, Southampton, Hants - England
[44] Univ Edinburgh, Inst Evolutionary Biol, Edinburgh, Midlothian - Scotland
Total Affiliations: 44
|
| Document type: | Journal article |
| Source: | Science; v. 369, n. 6508, SI, p. 1255+, SEP 4 2020. |
| Web of Science Citations: | 124 |
| Abstract | |
Brazil currently has one of the fastest-growing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemics in the world. Because of limited available data, assessments of the impact of nonpharmaceutical interventions (NPIs) on this virus spread remain challenging. Using a mobility-driven transmission model, we show that NPIs reduced the reproduction number from >3 to 1 to 1.6 in Sao Paulo and Rio de Janeiro. Sequencing of 427 new genomes and analysis of a geographically representative genomic dataset identified >100 international virus introductions in Brazil. We estimate that most (76%) of the Brazilian strains fell in three clades that were introduced from Europe between 22 February and 11 March 2020. During the early epidemic phase, we found that SARS-CoV-2 spread mostly locally and within state borders. After this period, despite sharp decreases in air travel, we estimated multiple exportations from large urban centers that coincided with a 25% increase in average traveled distances in national flights. This study sheds new light on the epidemic transmission and evolutionary trajectories of SARS-CoV-2 lineages in Brazil and provides evidence that current interventions remain insufficient to keep virus transmission under control in this country. (AU) | |
| FAPESP's process: | 20/04558-0 - Characterization of intrinsic risk factors and the development of new diagnostic and treatment alternatives for COVID-19 |
| Grantee: | José Luiz Proença Módena |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/00194-8 - Pathogenesis and neurovirulence of emerging viruses in Brazil |
| Grantee: | José Luiz Proença Módena |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 19/21301-5 - Flavivirus and Alphavirus identification in mosquitoes (Diptera: Culicidae) collected in the city of São Paulo |
| Grantee: | Camila Alves Maia da Silva |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 18/14389-0 - Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE) |
| Grantee: | Ester Cerdeira Sabino |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/14933-2 - Integrative biology applied to human health |
| Grantee: | Helder Takashi Imoto Nakaya |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 17/13981-0 - Characterization, genomics and diagnostic of viruses with importance for public health in Brazil by high throughput sequencing |
| Grantee: | William Marciel de Souza |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 20/04836-0 - Clinical and epidemiological study of SARS-CoV-2 in a prospective population and hospitalar cohorts in São José do Rio Preto, SP, Brazil in 2020 |
| Grantee: | Maurício Lacerda Nogueira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/25468-9 - Analysis of the human endogenous retrovirus in HTLV infected patients |
| Grantee: | Flavia Cristina da Silva Sales |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 16/18445-7 - Numerical methods for the next generation weather and climate models |
| Grantee: | Pedro da Silva Peixoto |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 18/09383-3 - Study about Flavivirus epitopes with medical importance in Brazil and its antibodies |
| Grantee: | Marcilio Jorge Fumagalli |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/17176-8 - Real-time, rapid detection and sequencing of arboviruses in Brazil: Zika, Dengue, Chikungunya and Yellow Fever |
| Grantee: | Ingra Morales Claro |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 19/12000-1 - Modeling of the spatiotemporal dispersion of emergent arboviruses using heterogeneous data sources in the State of São Paulo |
| Grantee: | Jaqueline Goes de Jesus |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/07544-2 - Mosquito field collections and COI barcode identification using MinION technology |
| Grantee: | Thaís de Moura Coletti |
| Support Opportunities: | Scholarships in Brazil - Technical Training Program - Technical Training |
| FAPESP's process: | 19/24251-9 - Multi-omic approaches for the study of Chikungunya disease |
| Grantee: | William Marciel de Souza |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |