Review on the potential application of non-phenolic compounds from native Latin American food byproducts in inflammatory bowel diseases

Author(s)

do Nascimento, Roberto de Paula ^[1] ; Moya, Amanda Maria Tomazini Munhoz ^[1] ; Machado, Ana Paula da Fonseca ^[1] ; Geraldi, Marina Vilar ^[1] ; Diez-Echave, Patricia ^[2] ; Vezza, Teresa ^[2] ; Galvez, Julio ^[2] ; Cazarin, Cinthia Bail Betim ^[1] ; Marostica, Jr., Mario Roberto ^[1]

Affiliation

^[1] Univ Campinas UNICAMP, Fac Sch Engn FEA, Sao Paulo - Brazil

^[2] Univ Granada, Inst Biosanitary Res Granada Ibs GRANADA, Biomed Res Ctr CIBM, Dept Pharmacol, CIBER EHD, Campus Salud, Granada 18071 - Spain

• Document type: Review article
• Source: Food Research International; v. 139, JAN 2021.
• Web of Science Citations: 0

Abstract

Inflammatory bowel diseases (IBDs), mainly Crohn's disease and ulcerative colitis, are high-prevalent chronic gastrointestinal disorders that may cause an important reduction in life quality. Such diseases are characterized by their immune-mediated inflammatory, oxidative and dysbiotic events, which can lead to important symptoms in patients, such as abdominal pain, bloody diarrhea and body weicght loss. In the last years, alternative natural options have been postulated for the prevention or treatment of IBDs, since common drug therapy may not be well accepted due to recurrent adverse effects and/or partial efficacy. Among those new natural products, agroindustrial byproducts, such as the peel and seed of foods, are emerging as cheap and pro-ecological options, as they are rich in bioactive compounds, such as polyphenols, but also in non-phenolic compounds, like unsaturated fatty acids, dietary fibers and prebiotics, carotenoids, bioactive peptides, and vitamins. In that sense, Latin America is rich in little explored native fruits and vegetables, from which great amounts of byproducts can be produced. Studies have shown that the byproducts from Latin American vegetables, such as passion-fruit (Passiflora edulis), pineapple (Ananas comosus) and pumpkin (Cucurbita spp.), for example, could represent interesting tools against IBDs, judging by the results of in vitro and animal studies. Therefore, the aim of this review is to discuss the potential role of non-phenolic compounds from native Latin American food byproducts in the prevention or treatment of IBDs, by highlighting their anti-inflammatory, anti-oxidative and/or anti-dysbiotic effects. (AU)

• FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
• Grantee: Glaucia Maria Pastore
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• FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/12244-8 - Effect of jabuticaba (Plinia jaboticaba) peel supplementation on metabolic profile in obese pre-diabetic subjects: a randomized, double-blinded, controlled trial
• Grantee: Marina Vilar Geraldi
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/23657-6 - Development of microparticles containing grape skin extract through the emerging technique SAS and evaluation of their antioxidant and anti-inflammatory effects in the treatment of induced Colitis in rats
• Grantee: Ana Paula da Fonseca Machado
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants