Chemoprevention with a tea from hawthorn (Crataegus oxyacantha) leaves and flowers attenuates colitis in rats by reducing inflammation and oxidative stress

Author(s):Show less -

de Paula do Nascimento, Roberto ^[1] ; da Fonseca Machado, Ana Paula ^[1] ; Lima, Verena Silva ^{[1, 2]} ; Tomazini Munhoz Moya, Amanda Maria ^[1] ; Reguengo, Livia Mateus ^[1] ; Bogusz Junior, Stanislau ^[3] ; Leal, Raquel Franco ^[4] ; Cao-Ngoc, Phu ; Rossi, Jean Christophe ^[5] ; Leclercq, Laurent ^[5] ; Cottet, Herve ^[5] ; Betim Cazarin, Cinthia Bau ^[1] ; Marostica Junior, Mario Roberto ^[1]

Affiliation

^[1] Univ Estadual Campinas, Sch Food Engn, Campinas, SP - Brazil

^[2] Univ Fed Amazonas, Inst Hlth & Biotechnol, Coari, Amazonas - Brazil

^[3] Univ Sao Paulo, Inst Chem Sao Carlos, Sao Carlos, SP - Brazil

^[4] Univ Estadual Campinas, Sch Med Sci, Surg Dept, Colorectal Surg Unit, IBD Res Lab, Campinas, SP - Brazil

^[5] Phu Cao-Ngoc, Univ Montpellier, ENSCM, CNRS, IBMM, Montpellier - France

• Document type: Journal article
• Source: FOOD CHEMISTRY-X; v. 12, DEC 30 2021.
• Web of Science Citations: 0

Abstract

The purpose of the study was to determine the effects of a tea from the leaves and flowers of Crataegus oxyacantha in rats with colitis. Colitis was induced by administration of 2,4,6-trinitrobenzene sulfonic acid. Hawthorn tea (HT) (100 mg/kg) was given via gavage for 21 days and the mesalamine drug (100 mg/kg) was administrated during the period of disease onset. HT was rich in total phenolic compounds (16.5%), flavonoids (1.8%), and proanthocyanidins (1.5%); vitexin-2-O-rhamnoside was the main compound detected. Mesalamine and the HT diminished the length of the lesions formed in the colon, in addition to reducing the levels of myeloperoxidase and interleukin-1 beta. Mesalamine was able to significantly reverse the body weight loss, while HT improved the activity of glutathione reductase and catalase. Histological scoring was not changed by the interventions, but it was highly correlated with the necrotic area. HT given at 100 mg/kg can be effective against colitis. (AU)

• FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
• Grantee: Glaucia Maria Pastore
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
• Grantee: Mário Roberto Maróstica Junior
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/23657-6 - Development of microparticles containing grape skin extract through the emerging technique SAS and evaluation of their antioxidant and anti-inflammatory effects in the treatment of induced Colitis in rats
• Grantee: Ana Paula da Fonseca Machado
• Support Opportunities: Scholarships in Brazil - Post-Doctoral