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Study of limiting factors to physical exercise and the effects of adjuncts to rehabilitation on cardiorespiratory disease: a multicentre approach

Grant number: 15/26501-1
Support type:Research Projects - Thematic Grants
Duration: December 01, 2017 - November 30, 2022
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Audrey Borghi e Silva
Grantee:Audrey Borghi e Silva
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos, SP, Brazil
Co-Principal Investigators:Renata Gonçalves Mendes
Assoc. researchers: Claudio Ricardo de Oliveira ; Fabíola Paula Galhardo Rizzatti ; Meliza Goi Roscani ; Renata Trimer
Associated scholarship(s):18/03314-0 - Follow-up of cardiorrespiratory changes and its impact on capacity of physical exercise in patients with heart failure and COPD overlap, BP.DD
18/11989-7 - Study of limiting factors to physical exercise and effects of rehabilitation facilities in chronic cardiorespiratory diseases: a multicentric approach, BP.TT
18/08198-8 - Investigation of functional capacity and arterial function during exercise in patients with COPD, BP.IC
18/03233-0 - Study of cardiorespiratory interaction and the supply of peripheral and cerebral oxygen as modulators of exercise capacity during bilevel application in the coexistence of COPD-CHF, BP.DD


This proposal comes up for a thematic project involving 2 subprojects of interdependent research and 15 researchers, 6 associate research, 5 international researchers and 3 national researchers from other institutions. In this theme, we propose as the original study a patient follow-up study with COPD, CHF and its coexistence, assessing the impact on morbidity and disability. Also we will investigate prognostic markers from cardiopulmonary exercise testing, through an international partnership, the Consortium Friends, in the context of these diseases and its coexistence. The mechanistic investigation of the limiting factors to exercise on cardiorespiratory function and diaphragmatic, peripheral muscle oxygenation and brain will be important for the integrated understanding of the systems to chronic cardiorespiratory dysfunction in these patients, constituting an important physiological study. We also propose as unpublished essay, the assessment of functional capacity through simple field tests, but on a prototype developed in our institution as well as its construction, expanding its clinical use. In the research line on the adjunct effects of rehabilitation in chronic cardiorespiratory diseases, we propose as original trial, a randomized study evaluating the effects of non-invasive ventilation in patients with CHF + COPD in the chronic phase as well as during exacerbations in different clinical and cardiovascular outcomes. For this, we gathered groups of notorious researchers know to help us in this great proposal, which will surely bring great impact in the scientific field. (AU)