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Study of limiting factors to physical exercise and the effects of adjuncts to rehabilitation on cardiorespiratory disease: a multicentre approach

Grant number: 15/26501-1
Support type:Research Projects - Thematic Grants
Duration: December 01, 2017 - November 30, 2022
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal researcher:Audrey Borghi e Silva
Grantee:Audrey Borghi e Silva
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Pesquisadores principais:
Renata Gonçalves Mendes
Assoc. researchers: Claudio Ricardo de Oliveira ; Fabíola Paula Galhardo Rizzatti ; Meliza Goi Roscani ; Renata Trimer
Associated scholarship(s):21/02784-5 - Study of factors limiting physical exercise and effects of resources associated with rehabilitation in chronic cardiorrespiratory diseases: a multicentric approach, BP.TT
21/03493-4 - Innovative assessment tool functional and guiding physical exercise prescription in patients with COPD exacerbated: investigation of clinical applicability and vascular and functional benefits, BP.DD
19/23548-8 - Investigation of phenotype in exacerbated COPD: do the major impact and symtomatology reflect in worst heart autonomic modulation, BP.IC
+ associated scholarships 19/20419-2 - Development of a cardiopulmonary health record - Friends Study, BP.EP
19/13068-9 - Validity and reliability of the sleep quality index questionnaire in individuals with chronic obstructive pulmonary disease, BP.IC
19/12515-1 - STUDY OF LIMITING FACTORS TO PHYSICAL EXERCISE AND EFFECTS OF RESOURCES TO REHABILITATION IN CHRONIC HEART DISEASE DISEASES - A MULTICENTRIC APPROACH, BP.TT
19/09828-8 - Analysis of variability of cardiac frequency during constant load exercise with application of binível in COPD-HF patients, BP.IC
18/18133-0 - Evaluation of mechanical ventilatory, cardiocirculatory and metabolic responses in dynamic exercise incremental symptom limited trial - FRIENDS Study, BP.PD
18/03314-0 - Follow-up of cardiorrespiratory changes and its impact on capacity of physical exercise in patients with heart failure and COPD overlap, BP.DD
18/11989-7 - Study of limiting factors to physical exercise and effects of rehabilitation facilities in chronic cardiorespiratory diseases: a multicentric approach, BP.TT
18/08198-8 - Investigation of functional capacity and arterial function during exercise in patients with COPD, BP.IC
18/03233-0 - Study of cardiorespiratory interaction and the supply of peripheral and cerebral oxygen as modulators of exercise capacity during bilevel application in the coexistence of COPD-CHF, BP.DD - associated scholarships

Abstract

This proposal comes up for a thematic project involving 2 subprojects of interdependent research and 15 researchers, 6 associate research, 5 international researchers and 3 national researchers from other institutions. In this theme, we propose as the original study a patient follow-up study with COPD, CHF and its coexistence, assessing the impact on morbidity and disability. Also we will investigate prognostic markers from cardiopulmonary exercise testing, through an international partnership, the Consortium Friends, in the context of these diseases and its coexistence. The mechanistic investigation of the limiting factors to exercise on cardiorespiratory function and diaphragmatic, peripheral muscle oxygenation and brain will be important for the integrated understanding of the systems to chronic cardiorespiratory dysfunction in these patients, constituting an important physiological study. We also propose as unpublished essay, the assessment of functional capacity through simple field tests, but on a prototype developed in our institution as well as its construction, expanding its clinical use. In the research line on the adjunct effects of rehabilitation in chronic cardiorespiratory diseases, we propose as original trial, a randomized study evaluating the effects of non-invasive ventilation in patients with CHF + COPD in the chronic phase as well as during exacerbations in different clinical and cardiovascular outcomes. For this, we gathered groups of notorious researchers know to help us in this great proposal, which will surely bring great impact in the scientific field. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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Scientific publications (20)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, REBECA NUNES; GOULART, CASSIA DA LUZ; OLIVEIRA, MURILO REZENDE; TACAO, GUILHERME YASSUYUKI; BACK, GUILHERME DIONIR; SEVERIN, RICHARD; FAGHY, MARK A.; ARENA, ROSS; BORGHI-SILVA, AUDREY. Cardiorespiratory and skeletal muscle damage due to COVID-19: making the urgent case for rehabilitation. EXPERT REVIEW OF RESPIRATORY MEDICINE, v. 15, n. 9, p. 1107-1120, SEP 2 2021. Web of Science Citations: 0.
CASTELLO-SIMOES, VIVIANE; KABBACH, ERIKA ZAVAGLIA; SCHAFAUSER, NATHANY SOUZA; CAMARGO, PATRICIA FARIA; SIMOES, RODRIGO POLAQUINI; HEUBEL, ALESSANDRO DOMINGUES; ALQAHTANI, JABER SAUD; DA CUNHA MARTINO PEREIRA, MARIANA BRASIL; SGARBOSA, NICOLE MARQUES; BORGHI-SILVA, AUDREY; MENDES, RENATA GONCALVES. Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease. RESPIRATORY MEDICINE, v. 185, AUG-SEP 2021. Web of Science Citations: 0.
OLIVEIRA, MURILO REZENDE; BACK, GUILHERME DIONIR; GOULART, CASSIA DA LUZ; DOMINGOS, BIANCA CRISTINA; ARENA, ROSS; BORGHI-SILVA, AUDREY. Endothelial function provides early prognostic information in patients with COVID-19: A cohort study. RESPIRATORY MEDICINE, v. 185, AUG-SEP 2021. Web of Science Citations: 1.
BORGHI-SILVA, AUDREY; GOULART, CASSIA DA LUZ; CARRASCOSA, CLAUDIA R.; OLIVEIRA, CRISTINO CARNEIRO; BERTON, DANILO C.; DE ALMEIDA, DIRCEU RODRIGUES; NERY, LUIZ EDUARDO; ARENA, ROSS; NEDER, J. ALBERTO. Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction. FRONTIERS IN PHYSIOLOGY, v. 12, JUN 21 2021. Web of Science Citations: 0.
BORGHI-RICARDO, MATHEUS; SIMOES, RODRIGO POLAQUINI; SANTOS, DANIEL AUGUSTO; ARCHIZA, BRUNO; BORGHI-SILVA, AUDREY. Effects of Aging on Hemodynamic Kinetics in Different Intensities of Dynamic Exercise. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, JUN 2021. Web of Science Citations: 0.
HEUBEL, ALESSANDRO DOMINGUES; KABBACH, ERIKA ZAVAGLIA; SCHAFAUSER, NATHANY SOUZA; PHILLIPS, SHANE AARON; PIRES DI LORENZO, VALERIA AMORIM; SILVA, AUDREY BORGHI; MENDES, RENATA GONCALVES. Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients. RESPIRATORY MEDICINE, v. 181, MAY 2021. Web of Science Citations: 0.
SILVA, REBECA NUNES; GOULART, CASSIA DA LUZ; OLIVEIRA, MURILO REZENDE; TACAO, GUILHERME YASSUYUKI; BACK, GUILHERME DIONIR; SEVERIN, RICHARD; FAGHY, MARK A.; ARENA, ROSS; BORGHI-SILVA, AUDREY. Cardiorespiratory and skeletal muscle damage due to COVID-19: making the urgent case for rehabilitation. EXPERT REVIEW OF RESPIRATORY MEDICINE, MAR 2021. Web of Science Citations: 0.
KABBACH, ERIKA ZAVAGLIA; HEUBEL, ALESSANDRO DOMINGUES; DA LUZ GOULART, CASSIA; DI LORENZO, VALERIA AMORIM PIRES; PHILLIPS, SHANE A.; BORGHI-SILVA, AUDREY; MENDES, RENATA GONCALVES. Association of exercise capacity and endothelial function in patients with severe exacerbations of chronic obstructive pulmonary disease. SCIENTIFIC REPORTS, v. 11, n. 1 JAN 11 2021. Web of Science Citations: 0.
GOULART, CASSIA LUZ; TINOCO AREAS, GUILHERME PEIXOTO; CARUSO, FLAVIA ROSSI; GARCIA ARAUJO, ADRIANA S.; GARCIA DE MOURA, SILVIA CRISTINA; CATAI, APARECIDA MARIA; BELTRAME, THOMAS; DE CARVALHO JUNIOR, LUIZ CARLOS; DOS SANTOS, POLLIANA BATISTA; ROSCANI, MELIZA GOI; MENDES, RENATA GONCALVES; ARENA, ROSS; BORGHI-SILVA, AUDREY. Effect of high-intensity exercise on cerebral, respiratory and peripheral muscle oxygenation of HF and COPD-HF patients. HEART & LUNG, v. 50, n. 1, p. 113-120, JAN-FEB 2021. Web of Science Citations: 1.
C.L. GOULART; F.R. CARUSO; G.P.T. ARÊAS; P.B. DOS SANTOS; P.F. CAMARGO; L.C.S. DE CARVALHO; M.G. ROSCANI; R.G. MENDES; A. BORGHI-SILVA. Impact of chronic obstructive pulmonary disease on linear and nonlinear dynamics of heart rate variability in patients with heart failure. Brazilian Journal of Medical and Biological Research, v. 54, n. 2, p. -, 2021. Web of Science Citations: 0.
DOS SANTOS, POLLIANA B.; SIMOES, RODRIGO P.; GOULART, CASSIA L.; ROSCANI, MELIZA G.; MARINHO, RENAN S.; CAMARGO, PATRICIA FARIA; ARBEX, RENATA F.; CASALE, GUILHERME; OLIVEIRA, CLAUDIO R.; MENDES, RENATA G.; ARENA, ROSS; BORGHI-SILVA, AUDREY. Eccentric Left Ventricular Hypertrophy and Left and Right Cardiac Function in Chronic Heart Failure with or without Coexisting COPD: Impact on Exercise Performance. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 16, p. 203-214, 2021. Web of Science Citations: 0.
MARINHO, R. S.; JURGENSEN, S. P.; ARCURI, J. F.; GOULART, C. L.; DOS SANTOS, P. B.; ROSCANI, M. G.; MENDES, R. G.; DE OLIVEIRA, C. R.; CARUSO, F. R.; BORGHI-SILVA, A. Reliability and validity of six-minute step test in patients with heart failure. Brazilian Journal of Medical and Biological Research, v. 54, n. 10 2021. Web of Science Citations: 0.
PANTONI, C. B. F.; DI THOMMAZO-LUPORINI, L.; MENDES, R. G.; CARUSO, F. C. R.; CASTELLO-SIMOES, V; MEZZALIRA, D.; BORGHI-SILVA, A. Effect of continuous positive airway pressure associated to exercise on the breathing pattern and heart rate variability of patients undergoing coronary artery bypass grafting surgery: a randomized controlled trial. Brazilian Journal of Medical and Biological Research, v. 54, n. 11 2021. Web of Science Citations: 0.
DA LUZ GOULART, CASSIA; TRIMER, RENATA; GARCIA-ARAUJO, ADRIANA SANCHES; CARUSO, FLAVIA ROSSI; RICCI, PAULA ANGELICA; SANTOS, POLLIANA BATISTA; MENDES, RENATA GONCALVES; BORGHI-SILVA, AUDREY. Validity, intra and inter-reliability of manual evaluation of the respiratory muscle strength in asthmatic patients. PHYSIOTHERAPY RESEARCH INTERNATIONAL, JUN 2020. Web of Science Citations: 0.
GOULART, CASSIA LUZ; DOS SANTOS, POLLIANA BATISTA; CARUSO, FLAVIA ROSSI; TINOCO AREAS, GUILHERME PEIXOTO; MARINHO, RENAN SHIDA; CAMARGO, PATRICIA DE FARIA; ALEXANDRE, TIAGO SILVA; OLIVEIRA, CLAUDIO R.; GONCALVES DA SILVA, ANDREA LUCIA; MENDES, RENATA GONCALVES; ROSCANI, MELIZA GOI; BORGHI-SILVA, AUDREY. The Value of Cardiopulmonary Exercise Testing in Determining Severity in Patients with both Systolic Heart Failure and COPD. SCIENTIFIC REPORTS, v. 10, n. 1 MAR 9 2020. Web of Science Citations: 0.
SOARES DE CARVALHO JUNIOR, LUIZ CARLOS; TRIMER, RENATA; ZANGRANDO, KATIANY LOPES; TINOCO AREAS, GUILHERME PEIXOTO; CARUSO, FLAVIA ROSSI; BONJORNO JUNIOR, JOSE CARLOS; OLIVEIRA, CLAUDIO RICARDO; MENDES, RENATA; BORGHI-SILVA, AUDREY. Overlap syndrome: the coexistence of OSA further impairs cardiorespiratory fitness in COPD. Sleep and Breathing, v. 24, n. 4 JAN 2020. Web of Science Citations: 0.
CAMARGO, PATRICIA FARIA; DITOMASO-LUPORINI, LUCIANA; SOARES DE CARVALHO JR, LUIZ CARLOS; GOULART, CASSIA DA LUZ; SEBOLD, RAYANE; DOS SANTOS, POLLIANA BATISTA; ROSCANI, MELIZA GOI; BORGHI-SILVA, AUDREY. Association Between the Predictors of Functional Capacity and Heart Rate Off-Kinetics in Patients with Chronic Obstructive Pulmonary Disease. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 15, p. 1977-1986, 2020. Web of Science Citations: 0.
KAMILA MOHAMMAD KAMAL MANSOUR; CÁSSIA DA LUZ GOULART; LUIZ CARLOS SOARES DE CARVALHO-JUNIOR; RENATA TRIMER; AUDREY BORGHI-SILVA; ANDRÉA LÚCIA GONÇALVES DA SILVA. Pontos de corte da função pulmonar e capacidade funcional determinantes para sarcopenia e dinapenia em pacientes com DPOC. Jornal Brasileiro de Pneumologia, v. 45, n. 6, p. -, 2019. Web of Science Citations: 1.
CARVALHO, JR., LUIZ CARLOS S.; TRIMER, RENATA; AREAS, GUILHERME P. T.; CARUSO, FLAVIA C. R.; ZANGRANDO, KATIANY T. L.; JURGENSEN, SORAIA PILON; BONJORNO, JR., JOSE C.; DE OLIVEIRA, CLAUDIO RICARDO; CABIDDU, RAMONA; MENDES, RENATA G.; BORGHI-SILVA, AUDREY. COPD assessment test and FEV1: do they predict oxygen uptake in COPD?. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 13, p. 3149-3156, 2018. Web of Science Citations: 2.
LOPES ZANGRANDO, KATIANY THAYS; TRIMER, RENATA; SOARES DE CARVALHO, JR., LUIZ CARLOS; TINOCO AREAS, GUILHERME PEIXOTO; ROSSI CARUSO, FLAVIA CRISTINA; CABIDDU, RAMONA; ROSCANI, MELIZA GOI; GALHARDO RIZZATTI, FABIOLA PAULA; BORGHI-SILVA, AUDREY. Chronic obstructive pulmonary disease severity and its association with obstructive sleep apnea syndrome: impact on cardiac autonomic modulation and functional capacity. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 13, p. 1343-1351, 2018. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.