Cancer and heart: new paradigms of diagnosis and treatment

• Grant number: 15/22814-5
• Support Opportunities: Research Projects - Thematic Grants
• Start date: November 01, 2016
• End date: October 31, 2022
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Carlos Eduardo Negrão
• Grantee: Carlos Eduardo Negrão
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais:( Últimos ): Anamaria Aranha Camargo ; Ludhmila Abrahão Hajjar ; Maria Janieire de Nazaré Nunes Alves ; Maria Urbana Pinto Brandão Rondon ; Patricia Chakur Brum ; Paulo Marcelo Gehm Hoff ; Roberto Kalil Filho ; Roger Chammas
• Pesquisadores principais:( Antigos ): Edilamar Menezes de Oliveira
• Associated researchers: Christina May Moran de Brito ; Fátima Solange Pasini ; Gilberto de Castro Junior ; Julio Cesar Batista Ferreira ; Luciana Nogueira de Sousa Andrade ; Luiz Fernando Lima Reis ; Maria Cristina Rodrigues Rangel ; Marília Harumi Higuchi dos Santos ; Marisa Passarelli ; Paula Fontes Asprino ; Paulo Rizzo Ramires ; Renata de Freitas Saito ; Silvia Moreira Ayub Ferreira ; Tatiane Katsue Furuya
• Associated research grant(s): 20/00842-5 - Preventing respiratory muscle dysfunction to improve survival in chronic disease by targeting a novel drug-exercise therapeutic axis, AP.R SPRINT; 18/22579-4 - Exosomal microRNAs as circulating biomarkers and mediators of the cardioprotective effect in patients undergoing cancer therapies, AP.R SPRINT; 17/18081-8 - AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, AR.EXT; + associated grants 17/08548-6 - Autophagy: from molecular principles to human diseases, AR.EXT; 17/50029-6 - The use if RNA-based nano formulations to improve the efficacy of breast cancer treatment and reduce therapy-induced cardiotoxicity, AP.R SPRINT; 16/50336-3 - Predicting survival in non-small-cell lung cancer: a link between cancer cachexia, cardiorespiratory fitness and cancer immune surveillance?, AP.R SPRINT - associated grants
• Associated scholarship(s): 18/14491-0 - Role of aldehydes metabolism in the doxorubicin-induced cardiomyopathy: preventive and therapeutic effects of Alda-1, BP.PD; 17/22069-3 - The role of MicroRNA-33a and sirtuine protein 6 in the metabolism and progression of Colon Cancer in mummy submitted to aerobic physical training, BP.DR; 16/26169-0 - Potential therapeutic targets induced by aerobic exercise training for the treatment of cancer cachexia: a study of ribosomal proteins, BP.PD; + associated scholarships 17/13133-0 - Relative role of physical activity on mitochondrial density and bioenergetics of infiltrating T lymphocytes from tumor microenvironment, BP.PD; 16/22835-5 - Effects of voluntary physical activity on cardiac function and structure in animal models of cancer cachexia, BP.MS; 15/09919-2 - Circulating miRNAs as biomarkers of cardiotoxicity and therapeutic potential in breast cancer, BP.PD; 15/05427-8 - Impact of adjuvant chemotherapy in autonomic cardiovascular regulation in patients with colon cancer, BP.PD; 14/11671-6 - Effect of high intensity interval training versus continuous moderate in the peripheral reflex mechanisms of control of the sympathetic activity in patients with heart failure, BP.PD; 13/15651-7 - Effects of Aerobic Exercise Training Associated with Inspiratory Muscle Training on Skeletal Myopathy in Patients with Heart Failure, BP.PD; 13/07651-7 - Prognostic value of the oscillatory pattern of muscle sympathetic nerve activity in patients with heart failure, BP.PD - associated scholarships

Abstract

Despite of the uninterrupted development of new medications for the treatment of cancer, the survival rate continues low especially in those patients in the advanced stage of the disease. Recent observations show that new therapeutics increase the susceptibility for cardiovascular diseases, which turns out to be the treatment of cancer even more complex. Cardiac dysfunction due to cardiotoxicity has been found in 10-15% breast cancer patients submitted to chemotherapy. Cardiac alterations associated with autonomicdysfunction have been recently documented in patients submitted to radiotherapy for treatment of lymphoma. Body weight gain, insulin resistance and hyperglycemia, dyslipidemia, and high blood pressure are very frequent in patients submitted to androgenic blockade or orquiectomy for the treatment of prostate adenocarcinoma. Therefore, the search for new treatments for cancer and elimination of collateral events caused by medications are great challenge in nowadays.Physical inactivity is very common in oncological patients. The debilitation due to the disease, treatment and demotivation contribute to the low level of physical activity in patients with cancer. On the other hand, studies involving large number of individual are unanimous in demonstrating the significant association between physical fitness and survival rate regardless of diseases. This knowledge suggests that exercise training may be an adjuvant strategy in the treatment of cancer. In fact, recent studies demonstrate that exercise training improves physical capacity and quality of life in patients suffering of cancer.The aim of our investigation is to search the molecular and autonomic mechanisms involved in the cardiovascular alterations provoked by cancer or chemotherapy and radiotherapy used in the treatment of this disease. Not less important will be the studies focused on the new therapeutic paradigms based on cellular and molecular principles, medications and exercise training for the treatment of cardiovascular diseases associated with cancer with special attention in the cardiac and skeletal toxicity.To accomplish these goals, 21 studies will be conducted in three areas: Cardio/Oncology, Oncologye Cardiology. (AU)

Scientific publications

(61)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

T.F. CUNHA; J.S. VIEIRA; J.B. SANTOS; M.A. COELHO; P.C. BRUM; D. GABRIEL-COSTA. Lactate modulates cardiac gene expression in mice during acute physical exercise. Brazilian Journal of Medical and Biological Research, v. 55, 2022-04-27. (14/25957-9, 15/22814-5)

TREVIZAN, PATRICIA F.; ANTUNES-CORREA, LIGIA M.; LOBO, DENISE M. L.; OLIVEIRA, PATRICIA A.; DE ALMEIDA, DIRCEU R.; ABDUCH, MARIA CRISTINA D.; MATHIAS JUNIOR, WILSON; HAJJAR, LUDHMILA ABRAHAO; KALIL FILHO, ROBERTO; NEGRAO, CARLOS EDUARDO. Effects of inspiratory muscle training combined with aerobic exercise training on neurovascular control in chronic heart failure patients. ESC HEART FAILURE, JUN 2021. (13/15651-7, 15/22814-5)

ALVES, CHRISTIANO R. R.; NEVES, WILLIAN DAS; ALMEIDA, NEY R. DE; EICHELBERGER, ERIC J.; JANNIG, PAULO R.; VOLTARELLI, VANESSA A.; TOBIAS, GABRIEL C.; BECHARA, LUIZ R. G.; FARIA, DANIELE DE PAULA; ALVES, MARIA J. N.; et al. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/ TRIP15/ALIEN. MOLECULAR METABOLISM, v. 39, SEP 2020. (16/50336-3, 12/02528-0, 14/03016-8, 12/25240-1, 15/22814-5, 16/01478-0, 16/20187-6)

ANTUNES-CORREA, LIGIA M.; TREVIZAN, PATRICIA F.; BACURAU, ALINE V. N.; FERREIRA-SANTOS, LARISSA; GOMES, JOAO L. P.; URIAS, URSULA; OLIVEIRA, PATRICIA A.; ALVES, MARIA JANIEIRE N. N.; DE ALMEIDA, DIRCEU R.; BRUM, PATRICIA C.; et al. Effects of aerobic and inspiratory training on skeletal muscle microRNA-1 and downstream-associated pathways in patients with heart failure. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, NOV 2019. (15/22814-5, 13/15651-7)

GABRIEL-COSTA, D.; CUNHA, T. F.; PAIXAO, N. A.; FORTUNATO, R. S.; REGO-MONTEIRO, I. C. C.; BARRETO-CHAVES, M. L. M.; BRUM, P. C.. Lactate-upregulation of lactate oxidation complex-related genes is blunted in left ventricle of myocardial infarcted rats. Brazilian Journal of Medical and Biological Research, v. 51, n. 11, 2018. (15/22814-5)

PEIXOTO DA FONSECA, GUILHERME WESLEY; DOS SANTOS, MARCELO RODRIGUES; DE SOUZA, FRANCIS RIBEIRO; DA COSTA, MARCEL JOSE A.; VON HAEHLING, STEPHAN; TAKAYAMA, LILIAM; PEREIRA, ROSA MARIA R.; NEGRAO, CARLOS EDUARDO; ANKER, STEFAN D.; DE NAZARE NUNES ALVES, MARIA JANIEIRE. Desequilíbrio Simpático-Vagal está Associado com Sarcopenia em Pacientes do Sexo Masculino com Insuficiência Cardíaca. Arquivos Brasileiros de Cardiologia, v. 112, n. 6, p. 739-746, JUN 2019. (16/24306-0, 15/22814-5)

KLUSER SALES, ALLAN ROBSON; NEGRAO, MARCELO VAILATI; TESTA, LAURA; FERREIRA-SANTOS, LARISSA; RAMALHO GROEHS, RAPHAELA VILLAR; CARVALHO, BRUNA; TOSCHI-DIAS, EDGAR; ROCHA, NATALIA GALITO; MARTINS LAURINDO, FRANCISCO RAFAEL; DEBBAS, VICTOR; et al. Chemotherapy acutely impairs neurovascular and hemodynamic responses in women with breast cancer. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 317, n. 1, p. H1-H12, JUL 2019. (14/11671-6, 15/22814-5)

ALVES, CHRISTIANO R. R.; EICHELBERGER, ERIC J.; DAS NEVES, WILLIAN; RIBEIRO, MARCIO A. C.; BECHARA, LUIZ R. G.; VOLTARELLI, VANESSA A.; DE ALMEIDA, NEY R.; HAGEN, LARS; SHARMA, ANIMESH; FERREIRA, JULIO C. B.; et al. Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity. FASEB JOURNAL, v. 35, n. 7, JUL 2021. (16/50336-3, 16/01478-0, 12/25240-1, 16/20187-6, 15/22814-5, 14/03016-8, 12/02528-0)

KE, WEINA; HONG, ENPING; SAITO, RENATA F.; RANGEL, MARIA CRISTINA; WANG, JIAN; VIARD, MATHIAS; RICHARDSON, MELINA; KHISAMUTDINOV, EMIL F.; PANIGAJ, MARTIN; DOKHOLYAN, V, NIKOLAY; et al. RNA-DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-B in human cells. Nucleic Acids Research, v. 47, n. 3, p. 1350-1361, FEB 20 2019. (17/50029-6, 15/22814-5)

VIEIRA, J. S.; CUNHA, T. F.; PAIXAO, N. A.; DOURADO, P. M.; CARRASCOZA, L. S.; BACURAU, A. V. N.; BRUM, P. C.. Exercise intolerance establishment in pulmonary hypertension: Preventive effect of aerobic exercise training. Life Sciences, v. 261, NOV 15 2020. (15/22814-5, 16/24284-6, 14/25957-9)

BUSTOS, SILVINA ODETE; ANTUNES, FERNANDA; RANGEL, MARIA CRISTINA; CHAMMAS, ROGER. Emerging Autophagy Functions Shape the Tumor Microenvironment and Play a Role in Cancer Progression-Implications for Cancer Therapy. FRONTIERS IN ONCOLOGY, v. 10, NOV 25 2020. (15/22814-5, 14/03742-0)

KIYUNA, LIGIA AKEMI; PRESTES E ALBUQUERQUE, RUDA; CHEN, CHE-HONG; MOCHLY-ROSEN, DARIA; BATISTA FERREIRA, JULIO CESAR. Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities. Free Radical Biology and Medicine, v. 129, p. 155-168, DEC 2018. (17/16694-2, 17/14426-0, 16/00900-0, 15/22814-5, 15/20783-5, 12/05765-2, 13/07937-8)

DOS SANTOS, MARCELO RODRIGUES; PEIXOTO DA FONSECA, GUILHERME WESLEY; SHERVENINAS, LETICIA PIRONATO; DE SOUZA, FRANCIS RIBEIRO; BATTAGLIA FILHO, ANTONIO CARLOS; NOVAES, CAIO EDUARDO; RODRIGUES PEREIRA, ROSA MARIA; NEGRAO, CARLOS EDUARDO; PEREIRA BARRETTO, ANTONIO CARLOS; DE NAZARE NUNES ALVES, MARIA-JANIEIRE. Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure. ESC HEART FAILURE, v. 7, n. 3, MAR 2020. (15/22814-5, 16/24833-0, 16/24306-0)

PELOZIN, BRUNO R. A.; SOCI, URSULA P. R.; GOMES, JOAO L. P.; OLIVEIRA, EDILAMAR M.; FERNANDES, TIAGO. TOR signaling-related microRNAs as cardiac hypertrophy modulators in high-volume endurance trainin. Journal of Applied Physiology, v. 132, n. 1, p. 126-139, JAN 2022. (15/22814-5, 15/17275-8)

PEREIRA, MARCELO G.; VOLTARELLI, VANESSA A.; TOBIAS, GABRIEL C.; DE SOUZA, LARA; BORGES, GABRIELA S.; PAIXAO, AILMA O.; DE ALMEIDA, NEY R.; BOWEN, THOMAS SCOTT; DEMASI, MARILENE; MIYABARA, ELEN H.; et al. erobic Exercise Training and In Vivo Akt Activation Counteract Cancer Cachexia by Inducing a Hypertrophic Profile through eIF-2 alpha Modulatio. CANCERS, v. 14, n. 1, JAN 2022. (16/26169-0, 17/13133-0, 20/12279-3, 15/22814-5, 18/02351-9)

MORELLI, ANA PAULA; TORTELLI JR, THARCISIO CITRANGULO; SILVA MANCINI, MARIANA CAMARGO; BETIM PAVAN, ISADORA CAROLINA; SALVINO SILVA, LUIZ GUILHERME; SEVERINO, MATHEUS BRANDEMARTE; GRANATO, DANIELA CAMPOS; PESTANA, NATHALIE FORTES; SABOIA PONTE, LUIS GUSTAVO; PERUCA, GUILHERME FRANCISCO; et al. TAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinom. Neoplasia, v. 23, n. 10, p. 1048-1058, OCT 2021. (19/25582-9, 15/22814-5, 15/00311-1, 18/14818-9, 19/00607-9, 20/09527-5)

TOSCHI-DIAS, EDGAR; MONTANO, NICOLA; TOBALDINI, ELEONORA; TREVIZAN, PATRICIA F.; GROEHS, V, RAPHAELA; ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; LOBO, DENISE M.; SALES, ALLAN R. K.; UENO-PARDI, LINDA M.; et al. Oscillatory Pattern of Sympathetic Nerve Bursts Is Associated With Baroreflex Function in Heart Failure Patients With Reduced Ejection Fraction. FRONTIERS IN NEUROSCIENCE, v. 15, AUG 31 2021. (10/50048-1, 15/17642-0, 13/07651-7, 15/22814-5)

DE AVILA PELOZIN, BRUNO ROCHA; RENO SOCI, URSULA PAULO; PENTEADO GOMES, JOAO LUCAS; DE OLIVEIRA, EDILAMAR MENEZES; FERNANDES, TIAGO. MTOR Signaling-Related MicroRNAs As Cardiac Hypertrophy Modulators In High- Volume Endurance Training. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 53, n. 8, p. 1-pg., 2021-08-01. (15/22814-5, 15/17275-8)

CUNHA, MATEUS TRINCONI; DE SOUZA BORGES, ANA PAULA; JARDIM, VINICIUS CARVALHO; FUJITA, ANDRE; DE CASTRO JR, GILBERTO. Predicting survival in metastatic non-small cell lung cancer patients with poor ECOG-PS: A single-arm prospective study. CANCER MEDICINE, v. N/A, p. 11-pg., 2022-09-26. (15/22814-5, 16/20187-6, 18/21934-5, 19/03615-2)

MORELLI, ANA PAULA; TORTELLI, THARCISIO CITRANGULO JR JR; BETIM PAVAN, ISADORA CAROLINA; SILVA, FERNANDO RIBACK; GRANATO, DANIELA CAMPOS; PERUCA, GUILHERME FRANCISCO; PAULETTI, BIANCA ALVES; DOMINGUES, ROMENIA RAMOS; NEVES BEZERRA, ROSANGELA MARIA; DE MOURA, LEANDRO PEREIRA; et al. Metformin impairs cisplatin resistance effects in A549 lung cancer cells through mTOR signaling and other metabolic pathways. International Journal of Oncology, v. 58, n. 6, JUN 2021. (16/02483-7, 19/00607-9, 15/22814-5, 17/04269-5, 15/16601-9, 18/14818-9, 16/06457-0, 12/13558-7)

GOMES-SANTOS, IGOR L.; JORDAO, CAMILA P.; PASSOS, CLEVIA S.; BRUM, PATRICIA C.; OLIVEIRA, EDILAMAR M.; CHAMMAS, ROGER; CAMARGO, ANAMARIA A.; NEGRAO, CARLOS E.. Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 8, APR 1 2021. (16/21320-1, 15/19076-2, 15/22814-5, 14/13690-8)

SALES, ALLAN R. K.; AZEVEDO, LUCIENE F.; SILVA, THIAGO O. C.; RODRIGUES, AMANDA G.; OLIVEIRA, PATRICIA A.; JORDAO, CAMILA P.; ANDRADE, ANA C. M.; URIAS, URSULA; GUIMARAES, GUILHERME V.; BOCCHI, EDIMAR A.; et al. High-Intensity Interval Training Decreases Muscle Sympathetic Nerve Activity and Improves Peripheral Vascular Function in Patients With Heart Failure With Reduced Ejection Fraction. Circulation-Heart Failure, v. 13, n. 8, AUG 2020. (15/22814-5, 17/25613-6, 10/08990-1, 14/11671-6)

CUNHA, T. F.; VIEIRA, J. S.; SANTOS, J. B.; COELHO, M. A.; BRUM, P. C.; GABRIEL-COSTA, D.. Lactate modulates cardiac gene expression in mice during acute physical exercise. Brazilian Journal of Medical and Biological Research, v. 55, n. 1, p. 9-pg., 2022-01-01. (15/22814-5, 11/00728-9, 14/25957-9)

TORTELLI, JR., THARCISIO CITRANGULO; TAMURA, RODRIGO ESAKI; JUNQUEIRA, MARA DE SOUZA; MORORO, JANIO DA SILVA; BUSTOS, SILVINA ODETE; NATALINO, RENATO JOSE MENDONCA; RUSSELL, SHONAGH; DESAUBRY, LAURENT; STRAUSS, BRYAN ERIC; CHAMMAS, ROGER. Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells. AGING-US, v. 13, n. 18, p. 21914-21940, SEP 30 2021. (15/26580-9, 19/08147-7, 15/22814-5)

SILVEIRA, ANDRE; GOMES, JOAO; ROQUE, FERNANDA; FERNANDES, TIAGO; DE OLIVEIRA, EDILAMAR MENEZES. MicroRNAs in Obesity-Associated Disorders: The Role of Exercise Training. Obesity Facts, v. 15, n. 2, p. 13-pg., 2022-01-20. (15/22814-5, 17/22069-3, 15/17275-8)

IMPROTA-CARIA, ALEX C.; SOCI, URSULA P. R.; RODRIGUES, LUIS F.; FERNANDES, TIAGO; OLIVEIRA, EDILAMAR M.. MicroRNAs regulating pathophysiological processes in obesity: the impact of exercise training. CURRENT OPINION IN PHYSIOLOGY, v. 33, p. 7-pg., 2023-06-01. (18/22579-4, 22/00531-5, 15/22814-5, 21/06229-6, 22/02339-4)

DE CASTRO, G., JR.; DAS NEVES SILVA, W.; BORGES, A. P. D. S.; JARDIM, V. C.; BRUM, P. C. B. C.; FUJITA, A.. Impact of systemic inflammation, intramuscular adipose tissue content, and EORTC-QLQ-CAX24 symptom scale on the prognosis of patients with advanced non-small-cell lung cancer. Annals of Oncology, v. 31, p. 1-pg., 2020-09-01. (15/22814-5, 16/20187-6)

PATINO, ANGELICA M.; JUNQUEIRA, MARA S.; ZHANG, XIAOMENG; BAILEY, KATE; IBRAHIM-HASHIM, ARIG; GILLIES, ROBERT J.; CHAMMAS, ROGER. Transient increase of tumor perfusion using hypertonic saline. MOLECULAR CANCER THERAPEUTICS, v. 17, n. 1, p. 2-pg., 2018-01-01. (13/06120-8, 15/22814-5)

CAMPOS, JULIANE C.; CHEN, CHE-HONG; FERREIRA, JULIO C. B.. Comment on: ``Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients{''} by Etienne et al.. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, JUL 2020. (15/22814-5, 17/16540-5, 19/25049-9, 19/18444-9)

PEIXOTO DA FONSECA, GUILHERME WESLEY; MACEDO, TANIA GARFIAS; EBNER, NICOLE; DOS SANTOS, MARCELO RODRIGUES; DE SOUZA, FRANCIS RIBEIRO; MADY, CHARLES; TAKAYAMA, LILIAM; RODRIGUES PEREIRA, ROSA MARIA; DOEHNER, WOLFRAM; ANKER, STEFAN D.; et al. Ms, muscle strength, and functional capacity in patients with heart failure of Chagas disease and other aetiologies. ESC HEART FAILURE, AUG 2020. (15/22814-5, 16/24306-0)

ALVES, CHRISTIANO; GOODYEAR, LAURIE; BRUM, PATRICIA. Muscle metabolic stress determines cancer cachexia severity in mice. FRONTIERS IN PHYSIOLOGY, v. 13, p. 7-pg., 2022-11-28. (14/03016-8, 12/25240-1, 12/02528-0, 15/22814-5, 16/01478-0)

JOAQUIM, VICTOR HUGO ANTONIO; PEREIRA, NOEMY PINTO; FERNANDES, TIAGO; OLIVEIRA, EDILAMAR MENEZES. Circular RNAs as a Diagnostic and Therapeutic Target in Cardiovascular Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 3, p. 16-pg., 2023-02-01. (15/22814-5, 22/00531-5, 18/22579-4)

FONSECA, G. W. P. D.; DOS SANTOS, MARCELO RODRIGUES; DE SOUZA, FRANCIS RIBEIRO; TAKAYAMA, LILIAM; RODRIGUES PEREIRA, ROSA MARIA; NEGRAO, CARLOS EDUARDO; NUNES ALVES, MARIA-JANIEIRE DE NAZARE. Discriminating sarcopenia in overweight/obese male patients with heart failure: the influence of body mass index. ESC HEART FAILURE, v. 7, n. 1, DEC 2019. (15/22814-5, 16/24306-0)

FERNANDES, L. G.; TOBIAS, G. C.; PAIXAO, A. O.; DOURADO, P. M.; VOLTARELLI, V. A.; BRUM, P. C.. Exercise training delays cardiac remodeling in a mouse model of cancer cachexia. Life Sciences, v. 260, NOV 1 2020. (14/25830-9, 15/22814-5, 16/22835-5)

CAMPOS, JULIANE C.; BAEHR, LESLIE M.; GOMES, KATIA M. S.; BECHARA, LUIZ R. G.; VOLTARELLI, VANESSA A.; BOZI, LUIZ H. M.; RIBEIRO, MARCIO A. C.; FERREIRA, NIKOLAS D.; MOREIRA, JOSE B. N.; BRUM, PATRICIA C.; et al. Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy. SCIENTIFIC REPORTS, v. 8, AUG 7 2018. (12/14416-1, 16/01633-5, 15/22814-5, 15/20783-5)

RIANI COSTA, LUIZ AUGUSTO; BARRETO, RAPHAEL F.; DE LEANDRINI, SARAH MILANI MORAES; GURGEL, ALINE RACHEL BEZERRA; DE SALES, GABRIEL TOLEDO; VOLTARELLI, VANESSA AZEVEDO; DE CASTRO, JR., GILBERTO; FENTON, SALLY A. M.; TURNER, JAMES E.; KLAUSENER, CHRISTIAN; et al. The influence of a supervised group exercise intervention combined with active lifestyle recommendations on breast cancer survivors' health, physical functioning, and quality of life indices: study protocol for a randomized and controlled trial. Trials, v. 22, n. 1, DEC 18 2021. (15/22814-5, 20/12514-2, 17/13133-0, 16/50336-3)

TAKANO, ANA P. C.; CAMPOS, JULIANE C.; VOLTARELLI, VANESSA A.; FERREIRA, JULIO C. B.. Endoplasmic reticulum stress impairs cardiomyocyte contractility through JNK-dependent upregulation of BNIP3. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 272, p. 194-201, DEC 1 2018. (15/22814-5, 16/09611-0)

BALKRISHNAN, RAJESH; DESAI, RAJ P.; NARAYAN, ADITYA; CAMACHO, FABIAN T.; FLAUSINO, LUCAS E.; CHAMMAS, ROGER. Associations between initiating antihypertensive regimens on stage I-III colorectal cancer outcomes: A Medicare SEER cohort analysis. CANCER MEDICINE, v. 10, n. 15, JUN 2021. (20/15317-3, 15/22814-5)

CHAMMAS, ROGER; DE SOUSA ANDRADE, LUCIANA NOGUEIRA; JANCAR, SONIA. Oncogenic effects of PAFR ligands produced in tumours upon chemotherapy and radiotherapy. NATURE REVIEWS CANCER, v. 17, n. 4, APR 2017. (13/15719-0, 15/22814-5)

ILDEFONSO ALVES DA SILVA JUNIOR; LUCIANA NOGUEIRA DE SOUSA ANDRADE; SONIA JANCAR; ROGER CHAMMAS. Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy. Clinics, v. 73, 2018-10-11. (13/15719-0, 15/22814-5)

GARCIA, ADRIANA A.; KOPERNIKU, ANA; FERREIRA, JULIO C. B.; MOCHLY-ROSEN, DARIA. Treatment strategies for glucose-6-phosphate dehydrogenase deficiency: past and future perspectives. TRENDS IN PHARMACOLOGICAL SCIENCES, v. 42, n. 10, p. 829-844, OCT 2021. (15/22814-5, 13/07937-8, 18/18627-3, 19/25049-9)

AZEVEDO VOLTARELLI, VANESSA; CORONADO, MICHAEL; GONCALVES FERNANDES, LARISSA; CRUZ CAMPOS, JULIANE; JANNIG, PAULO ROBERTO; BATISTA FERREIRA, JULIO CESAR; FAJARDO, GIOVANNI; CHAKUR BRUM, PATRICIA; BERNSTEIN, DANIEL. beta(2)-Adrenergic Signaling Modulates Mitochondrial Function and Morphology in Skeletal Muscle in Response to Aerobic Exercise. CELLS, v. 10, n. 1, JAN 2021. (15/22814-5)

DIEGO SALES DE OLIVEIRA; LUCAS SERTORIO CARRASCOZA; NEY ROBSON DE ALMEIDA; LEANDRO CAMPOS DE BRITO; MARCELO MARQUES; LEANDRO SILVA ALVES; PATRICIA CHAKUR BRUM. Cardiovascular physiology and autonomic heart control principles: the use of a station rotation strategy to recall basic cardiovascular knowledge among exercise science students. Motriz: rev. educ. fis., v. 28, 2022-03-28. (15/22814-5, 16/19771-5, 16/50336-3)

PEIXOTO DA FONSECA, GUILHERME WESLEY; MACEDO, TANIA GARFIAS; EBNER, NICOLE; DOS SANTOS, MARCELO RODRIGUES; DE SOUZA, FRANCIS RIBEIRO; MADY, CHARLES; TAKAYAMA, LILIAM; RODRIGUES PEREIRA, ROSA MARIA; DOEHNER, WOLFRAM; ANKER, STEFAN D.; et al. Ms, muscle strength, and functional capacity in patients with heart failure of Chagas disease and other aetiologies. ESC HEART FAILURE, v. 7, n. 5, p. 9-pg., 2020-08-28. (15/22814-5, 16/24306-0)

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