Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation

• Grant number: 14/50265-3
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
• Start date: July 01, 2015
• End date: June 30, 2020
• Field of knowledge: Health Sciences - Pharmacy - Pharmacognosy
• Principal Investigator: Norberto Peporine Lopes
• Grantee: Norberto Peporine Lopes
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant(s): 17/50381-1 - Synthesis scale up and metabolic studies of natural and synthetic bioactive compounds, AP.R SPRINT
• Associated scholarship(s): 19/22357-4 - Metabolomic analysis of micromolecular biodiversity of the Atlantic Forest, BP.DR; 17/22001-0 - Synthesis and evaluation of new heterocyclic compounds as potential antitrypanosomal agents, BP.PD; 18/06125-3 - Metabolism and distribution of natural and synthetic xenobiotics: from the understanding of the reactional processes to the generation of tissue images, BP.TT; + associated scholarships 17/19330-1 - In vitro metabolism of steroidal alkaloids from Solanum paniculatum l. (Solanaceae), BP.MS; 17/04819-5 - Computational chemistry in studies of the reactivity of oxazolines: combining theory and experiment, BP.IC; 17/08385-0 - Reactivity and thermochemical parameters for lactones: application in mass spectrometry studies, BP.IC; 16/06366-5 - Natural and synthetic xenobiotics bioavailability on in vitro models, BP.PD; 16/13292-8 - Analysis of nitrogen content in antropic influenced areas in Amazon and Atlantic Forest using a metabolomic tools, BP.PD; 16/07787-4 - Development of a computational toolbox for the analysis of chiral molecular systems using vibrational circular dichroism, BP.PD; 15/24815-9 - Characterization of high and medium polarity compounds from different Lychnophora species in order to elucidate a new species, BP.IC - associated scholarships

Abstract

Brazil currently holds the largest biodiversity but the national herbal market is based in exotic plants trades. One of the bottlenecks regarding products development from native biodiversity is the lack of clinical and preclinical studies of natural prod (AU)

Scientific publications

(92)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TABOADA, CARLOS; BRUNETTI, ANDRES E.; PEDRON, FEDERICO N.; NETO, FAUSTO CARNEVALE; ESTRIN, DARIO A.; BARI, SARA E.; CHEMES, LUCA B.; LOPES, NORBERTO PEPORINE; LAGORIO, MARIA G.; FAIVOVICH, JULIAN. Naturally occurring fluorescence in frogs. Proceedings of the National Academy of Sciences of the United States of America, v. 114, n. 14, p. 3672-3677, APR 4 2017. (12/10000-5, 14/20915-6, 14/12343-2, 13/50741-7, 14/50265-3)

CARNEVALE NETO, FAUSTO; GUARATINI, THAIS; COSTA-LOTUFO, LETICIA; COLEPICOLO, PIO; GATES, PAUL J.; LOPES, NORBERTO PEPORINE. Re-investigation of the fragmentation of protonated carotenoids by electrospray ionization and nanospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry, v. 30, n. 13, p. 1540-1548, JUL 15 2016. (14/12343-2, 14/50265-3)

FONSECA, MONIQUE T.; MORETTI, EDUARDO H.; MARQUES, LUCAS M. M.; MACHADO, BIANCA F.; BRITO, CAMILA F.; GUEDES, JADY T.; KOMEGAE, EVILIN N.; VIEIRA, THAYNA S.; FESTUCCIA, WILLIAM T.; LOPES, NORBERTO P.; et al. A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation. Science Signaling, v. 14, n. 679, APR 20 2021. (16/23540-9, 18/03418-0, 17/17403-1, 17/13350-0, 15/19530-5, 16/04921-1, 20/09399-7, 14/50265-3, 14/03719-9, 18/00849-0)

GAZOLLA, MATHEUS COUTINHO; MAURIZ MARQUES, LUCAS MACIEL; GAMA E SILVA, MARIANA; MOURA FONTES ARAUJO, MARIA TAIS; MENDES, ROSEMAIRY LUCIANE; GUEDES DA SILVA ALMEIDA, JACKSON ROBERTO; VESSECCHI, RICARDO; LOPES, NORBERTO PEPORINE. Characterization of 3-aminospirostane alkaloids from roots of Solanum paniculatum L. with hepatoprotective activity. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, FEB 2020. (14/50265-3, 17/19330-1, 14/23604-1)

HABENSCHUS, MAISA DANIELA; MOREIRA, FERNANDA DE LIMA; LOPES, NORBERTO PEPORINE; DE OLIVEIRA, ANDERSON R. M.. In Vitro Inhibition of Human CYP450s 1A2, 2C9, 3A4/5, 2D6 and 2E1 by Grandisin. Planta Medica, v. 83, n. 8, p. 727-736, MAY 2017. (13/17658-9, 16/07597-0, 14/50265-3)

DA SILVA SIQUEIRA, EMERSON MICHELL; FELIX-SILVA, JULIANA; LIMA DE ARAUJO, LORENA MARIA; FERNANDES, JULIA MORAIS; CABRAL, BARBARA; DOS SANTOS GOMES, JACYRA ANTUNES; ROQUE, ALAN DE ARAUJO; TOMAZ, JOSE CARLOS; LOPES, NORBERTO PEPORINE; FERNANDES-PEDROSA, MATHEUS DE FREITAS; et al. Spondias tuberosa (Anacardiaceae) leaves: profiling phenolic compounds by HPLC-DAD and LC-MS/MS and in vivo anti-inflammatory activity. BIOMEDICAL CHROMATOGRAPHY, v. 30, n. 10, p. 1656-1665, OCT 2016. (14/50265-3)

BAUERMEISTER, ANELIZE; AGUIAR, FERNANDO ARMANI; MAURIZ MARQUES, LUCAS MACIEL; MALTA, JR., JOSE DOS SANTOS; BARROS, FABIO; CALLEJON, DANIEL ROBERTO; MORAES DE OLIVEIRA, ANDERSON RODRIGO; LOPES, NORBERTO PEPORINE. In Vitro Metabolism Evaluation of the Ergot Alkaloid Dihydroergotamine: Application of Microsomal and Biomimetic Oxidative Model. Planta Medica, v. 82, n. 15, p. 1368-1373, OCT 2016. (13/16496-5, 14/50265-3)

TEODORO, T. Q.; KOENIS, M. A. J.; RUGER, R.; GALEMBECK, S. E.; BUMA, W. J.; NICU, V. P.; VISSCHER, L.. Use of Density Functional Based Tight Binding Methods in Vibrational Circular Dichroism. Journal of Physical Chemistry A, v. 122, n. 49, p. 9435-9445, DEC 13 2018. (16/07787-4, 14/50265-3, 16/23165-3, 08/02677-0)

SILVA, DENISE BRENTAN; ASCHENBRENNER, ANNA-KATHARINA; LOPES, NORBERTO PEPORINE; SPRING, OTMAR. Direct Analyses of Secondary Metabolites by Mass Spectrometry Imaging (MSI) from Sunflower (Helianthus annuus L.) Trichomes. Molecules, v. 22, n. 5, MAY 2017. (14/50265-3, 09/54098-6)

MARCELA T. NAKAMURA; ELIANA H. ENDO; JOÃO PAULO B. DE SOUSA; DANIEL R. CALLEJON; TÂNIA UEDA-NAKAMURA; BENEDITO P. DIAS FILHO; OSVALDO DE FREITAS; CELSO V. NAKAMURA; NORBERTO P. LOPES. Copaiba Oil and Its Constituent Copalic Acid as Chemotherapeutic Agents against Dermatophytes. Journal of the Brazilian Chemical Society, v. 28, n. 8, p. 1377-1383, 2017-08-00. (14/50265-3)

LACHI-SILVA, LARISSA; SY, SHERWIN K. B.; VOELKNER, ALEXANDER; BARRETO DE SOUSA, JOAO PAULO; LOPES, JOAO LUIS C.; SILVA, DENISE B.; LOPES, NORBERTO P.; KIMURA, ELZA; DERENDORF, HARTMUT; DINIZ, ANDREA. Simultaneous Characterization of Intravenous and Oral Pharmacokinetics of Lychnopholide in Rats by Transit Compartment Model. Planta Medica, v. 81, n. 12-13, p. 1121-1127, AUG 2015. (14/50265-3, 12/18031-7, 09/54098-6)

DANTONIO, VALTER; BATALHAO, MARCELO E.; FERNANDES, MARCIA H. M. R.; KOMEGAE, EVILIN N.; BUQUI, GABRIELA A.; LOPES, NORBERTO P.; GARGAGLIONI, LUCIANE H.; CARNIO, EVELIN C.; STEINER, ALEXANDRE A.; BICEGO, KENIA C.. Nitric oxide and fever: immune-to-brain signaling vs. thermogenesis in chicks. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 310, n. 10, p. R896-R905, MAY 15 2016. (14/13586-6, 12/19966-0, 13/13386-4, 12/03831-8, 14/50265-3)

MOREIRA, FERNANDA DE LIMA; MOREIRA, MARCELA DE LIMA; PILON, ALAN CESAR; LOPES, NORBERTO PEPORINE. Leishmanicidal Effects of Piperlongumine (Piplartine) and Its Putative Metabolites. Planta Medica, v. 84, n. 15, p. 1141-1148, OCT 2018. (14/50265-3, 13/04188-4, 13/17658-9, 16/13292-8)

GOZALO-MARCILLA, M.; LUNA, S. P. L.; MOREIRA DA SILVA, R.; CROSIGNANI, N.; LOPES, N. P.; TAYLOR, P. M.; PELLIGAND, L.. Characterisation of the in vivo interactions between detomidine and methadone in horses: Pharmacokinetic and pharmacodynamic modelling. EQUINE VETERINARY JOURNAL, v. 51, n. 4, p. 517-529, JUL 2019. (17/01425-6, 10/08967-0, 14/50265-3, 14/00474-5)

ORENHA, RENATO PEREIRA; TFOUNI, ELIA; GALEMBECK, SERGIO EMANUEL. How does the total charge and isomerism influence the Ru-NO ammine complexes?. Physical Chemistry Chemical Physics, v. 20, n. 19, p. 13348-13356, MAY 21 2018. (11/20351-7, 08/02677-0, 15/15176-2, 06/53266-4, 14/50265-3)

WANG, MINGXUN; CARVER, JEREMY J.; PHELAN, VANESSA V.; SANCHEZ, LAURA M.; GARG, NEHA; PENG, YAO; NGUYEN, DON DUY; WATROUS, JERAMIE; KAPONO, CLIFFORD A.; LUZZATTO-KNAAN, TAL; et al. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. NATURE BIOTECHNOLOGY, v. 34, n. 8, p. 828-837, AUG 2016. (14/18052-0, 12/18031-7, 14/01651-8, 13/16496-5, 14/01884-2, 14/50265-3)

MOREIRA, FERNANDA DE LIMA; HABENSCHUS, MAISA D.; BARTH, THIAGO; MARQUES, LUCAS M. M.; PILON, ALAN CESAR; BOLZANI, VANDERLAN DA SILVA; VESSECCHI, RICARDO; LOPES, NORBERTO P.; DE OLIVEIRA, ANDERSON R. M.. Metabolic profile and safety of piperlongumine. SCIENTIFIC REPORTS, v. 6, SEP 29 2016. (13/17658-9, 14/50265-3, 14/23604-1)

FUMAGALLI, FERNANDO; EMERY, FLAVIO DA SILVA. Charting the Chemical Reactivity Space of 2,3-Substituted Furo[2,3-b]pyridines Synthesized via the Heterocyclization of Pyridine-N-oxide Derivatives. Journal of Organic Chemistry, v. 81, n. 21, p. 10339-10347, NOV 4 2016. (15/06588-5, 14/50265-3)

ORENHA, RENATO P.; GREGORIO, LETICIA R. SAN; GALEMBECK, SERGIO E.. Computational study of the interaction between NO, NO+, and NO- with H2O. Journal of Molecular Modeling, v. 22, n. 11, NOV 2016. (15/15176-2, 11/20351-7, 14/50265-3, 08/02677-0)

SILVA-JUNIOR, EDUARDO A.; PALUDO, CAMILA R.; AMARAL, JULIANO G.; GALLON, MARILIA E.; GOBBO-NETO, LEONARDO; NASCIMENTO, FABIO S.; LOPES, NORBERTO P.. Chemical Diversity in a Stingless Bee-Plant Symbiosis. ACS OMEGA, v. 4, n. 12, p. 15208-15214, SEP 17 2019. (14/50265-3, 15/05453-9)

GALLON, MARILIA ELIAS; SILVA-JUNIOR, EDUARDO AFONSO; AMARAL, JULIANO GERALDO; LOPES, NORBERTO PEPORINE; GOBBO-NETO, LEONARDO. Natural Products Diversity in Plant-Insect Interaction between Tithonia diversifolia (Asteraceae) and Chlosyne lacinia (Nymphalidae). Molecules, v. 24, n. 17, SEP 1 2019. (14/50265-3, 17/17023-4)

LANCHOTI FIORI, GIOVANA MARIA; D'AGATE, SALVATORE; ROCHA, ADRIANA; SOARES PEREIRA, ANA MARIA; DELLA PASQUA, O.; LOPES, NORBERTO PEPORINE. Development and validation of a quantification method for cucurbitacins E and I in rat plasma: Application to population pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis, v. 144, p. 7-pg., 2017-09-10. (12/14408-9, 14/50265-3)

TABOADA, CARLOS; BRUNETTI, ANDRES E.; PEDRON, FEDERICO N.; NETO, FAUSTO CARNEVALE; ESTRIN, DARIO A.; BARI, SARA E.; CHEMES, LUCA B.; LOPES, NORBERTO PEPORINE; LAGORIO, MARIA G.; FAIVOVICH, JULIAN. Naturally occurring fluorescence in frogs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 114, n. 14, p. 6-pg., 2017-04-04. (14/50265-3, 14/20915-6, 13/50741-7, 14/12343-2, 12/10000-5)

ALAN C. PILON; DENISE M. SELEGATO; RICHARD P. FERNANDES; PAULA C. P. BUENO; DANIELLE R. PINHO; FAUSTO CARNEVALE NETO; RAFAEL T. FREIRE; IAN CASTRO-GAMBOA; VANDERLAN S. BOLZANI; NORBERTO P. LOPES. METABOLÔMICA DE PLANTAS: MÉTODOS E DESAFIOS. Química Nova, v. 43, n. 3, p. 329-354, 2020-06-01. (13/07600-3, 14/05935-0, 19/15889-0, 17/17850-8, 14/50265-3, 17/19702-6, 15/50488-5, 19/08477-7, 14/50926-0, 16/13292-8)

ELIAS, LARISSA G.; SILVA, DENISE B.; SILVA, RICARDO; PENG, YAN-QIONG; YANG, DA-RONG; LOPES, NORBERTO P.; PEREIRA, RODRIGO A. S.. A comparative venomic fingerprinting approach reveals that galling and non-galling fig wasp species have different venom profiles. PLoS One, v. 13, n. 11, NOV 8 2018. (14/01884-2, 13/01918-1, 14/50265-3)

MENEGATTI, CARLA; DA PAIXAO MELO, WEILAN GOMES; CARRAO, DANIEL BLASCKE; MORAES DE OLIVEIRA, ANDERSON RODRIGO; DO NASCIMENTO, FABIO SANTOS; LOPES, NORBERTO PEPORINE; PUPO, MONICA TALLARICO. Paenibacillus polymyxa Associated with the Stingless Bee Melipona scutellaris Produces Antimicrobial Compounds against Entomopathogens. Journal of Chemical Ecology, v. 44, n. 12, p. 1158-1169, DEC 2018. (09/54098-6, 14/17620-4, 13/50954-0, 14/50265-3, 15/01001-6)

MAURO, MARIANA; DA SILVA, RODRIGO MOREIRA; DE CAMPOS, MICHEL LEANDRO; BAUERMEISTER, ANELIZE; LOPES, NORBERTO PEPORINE; DE MORAES, NATALIA VALADARES. In vitro metabolism of copalic and kaurenoic acids in rat and human liver microsomes. Química Nova, v. 44, n. 6, p. 700-708, 2021. (14/50265-3)

DIAS, HERBERT J.; PATROCINIO, ANDRESSA B.; PAGOTTI, MARIANA C.; FUKUI, MURILO J.; RODRIGUES, VANDERLEI; MAGALHAES, LIZANDRA G.; CROTTI, ANTONIO E. M.. Schistosomicidal Activity of Dihydrobenzofuran Neolignans. CHEMISTRY & BIODIVERSITY, v. 15, n. 7, JUL 2018. (13/20094-0, 09/12202-1, 13/11164-4, 16/24456-1, 14/50265-3)

FREIRE FRANCO, MARCIA SILVANA; DE PAULA, MURILO HELDER; GLOWACKA, PAULINA CECYLIA; FUMAGALLI, FERNANDO; CLOSOSKI, GIULIANO CESAR; EMERY, FLAVIO DA SILVA. Palladium-catalyzed C-H alkenylation of quinoxaline N-oxide enabled by a mono-N-protected amino acid. Tetrahedron Letters, v. 59, n. 26, p. 2562-2566, JUN 27 2018. (12/20990-2, 14/50265-3, 17/21146-4, 15/12811-9)

BRUNETTI, ANDRES E.; MARANI, MARIELA M.; SOLDI, RAFAEL A.; MENDONCA, JACQUELINE NAKAU; FAIVOVICH, JULIAN; CABRERA, GABRIELA M.; LOPES, NORBERTO P.. Cleavage of Peptides from Amphibian Skin Revealed by Combining Analysis of Gland Secretion and in Situ MALDI Imaging Mass Spectrometry. ACS OMEGA, v. 3, n. 5, p. 5426-5434, MAY 2018. (17/23725-1, 12/10000-5, 14/20915-6, 13/50741-7, 14/50265-3)

PINTO, MERI EMILI F.; NAJAS, JHENNY Z. G.; MAGALHAES, LUMA G.; BOBEY, ANTONIO F.; MENDONCA, JACQUELINE N.; LOPES, NORBERTO P.; LEME, FLAVIA M.; TEIXEIRA, SIMONE P.; TROVO, MARCELO; ANDRICOPULO, ADRIANO D.; et al. Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria. Journal of Natural Products, v. 81, n. 5, p. 1203-1208, MAY 2018. (17/17098-4, 14/50265-3, 13/07600-3)

DEMARQUE, DANIEL P.; CROTTI, ANTONIO E. M.; VESSECCHI, RICARDO; LOPES, JOAO L. C.; LOPES, NORBERTO P.. Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products. NATURAL PRODUCT REPORTS, v. 33, n. 3, p. 432-455, 2016. (13/20094-0, 14/23604-1, 14/20302-4, 14/18052-0, 14/50265-3)

MOREIRA, DUARDA ANTUNES; PILON, ALAN CESAR; ANDRADE, LAURA ELENA; LOPES, NORBERTO PEPORINE. New Perspectives on Chlorogenic Acid Accumulation in Harvested Leaf Tissue: Impact on Traditional Medicine Preparations. ACS OMEGA, v. 3, n. 12, p. 18380-18386, DEC 2018. (14/50265-3, 15/09227-3, 10/17935-4, 16/13292-8)

BRUNETTI, A. E.; CARNEVALE NETO, F.; VERA, M. C.; TABOADA, C.; PAVARINI, D. P.; BAUERMEISTER, A.; LOPES, N. P.. An integrative omics perspective for the analysis of chemical signals in ecological interactions. CHEMICAL SOCIETY REVIEWS, v. 47, n. 5, p. 1574-1591, MAR 7 2018. (14/12343-2, 13/50741-7, 14/20915-6, 14/50265-3)

DE MELLO, MURILO B. M.; DE OLIVEIRA, ANTONIO A. F.; DE OLIVEIRA, CAROLINE L.; ULTRAMARI, MARIAH A.; GAETA, FERNANDO H. S.; MASCARELLO, ALESSANDRA; GUIMARAES, CRISTIANO R. W.; DE FREITAS, MILLER N.; CUNHA, CARLOS E.; LOURENCO, TIAGO C.; et al. Characterization and in silico Mutagenic Assessment of a New Betahistine Degradation Impurity. Journal of the Brazilian Chemical Society, v. 30, n. 7, p. 1415-1424, JUL 2019. (18/14150-8, 15/12811-9, 14/50265-3)

FALCON, TIAGO; PINHEIRO, DANIEL G.; FERREIRA-CALIMAN, MARIA JULIANA; TURATTI, IZABEL C. C.; PINTO DE ABREU, FABIANO C.; GALASCHI-TEIXEIRA, JULIANA S.; MARTINS, JULIANA R.; ELIAS-NETO, MOYSES; SOARES, MICHELLE P. M.; LAURE, MARCELA B.; et al. Exploring integument transcriptomes, cuticle ultrastructure, and cuticular hydrocarbons profiles in eusocial and solitary bee species displaying heterochronic adult cuticle maturation. PLoS One, v. 14, n. 3, MAR 14 2019. (14/13136-0, 11/03171-5, 14/50265-3, 12/24284-5)

GALEMBECK, SERGIO E.; ORENHA, RENATO P.; MADEIRA, RAFAEL M.; PEIXOTO, LETICIA B.; PARREIRA, RENATO L. T.. Through-Bond and Through-Space Interactions in [2,2]Cyclophanes. Journal of the Brazilian Chemical Society, v. 32, n. 7, p. 1447-1455, JUL 2021. (08/02677-0, 17/24856-2, 11/07623-8, 17/04856-8, 14/50265-3)

GAUGLITZ, JULIA M.; WEST, KIANA A.; BITTREMIEUX, WOUT; WILLIAMS, CANDACE L.; WELDON, KELLY C.; PANITCHPAKDI, MORGAN; DI OTTAVIO, FRANCESCA; ACEVES, CHRISTINE M.; BROWN, ELIZABETH; SIKORA, NICOLE C.; et al. Enhancing untargeted metabolomics using metadata-based source annotation. NATURE BIOTECHNOLOGY, v. 40, n. 12, p. 17-pg., 2022-07-07. (14/50265-3)

NETO, FAUSTO CARNEVALE; ANDREO, MARCIO ADRIANO; RAFTERY, DANIEL; CALLEGARI LOPES, JOAO LUIS; LOPES, NORBERTO PEPORINE; CASTRO-GAMBOA, IAN; DE NORONHA SALES MAIA, BEATRIZ HELENA LAMEIRO; COSTA, EMMANOEL VILACA; VESSECCHI, RICARDO. Characterization of aporphine alkaloids by electrospray ionization tandem mass spectrometry and density functional theory calculations. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 34, n. 3, SI, OCT 2019. (10/07564-9, 14/23604-1, 03/02176-7, 14/12343-2, 09/08281-3, 14/50265-3)

LANCHOTI FIORI, GIOVANA MARIA; D'AGATE, SALVATORE; ROCHA, ADRIANA; SOARES PEREIRA, ANA MARIA; DELLA PASQUA, O.; LOPES, NORBERTO PEPORINE. Development and validation of a quantification method for cucurbitacins E and I in rat plasma: Application to population pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis, v. 144, n. SI, p. 99-105, SEP 10 2017. (14/50265-3, 12/14408-9)

SILVA, DANIEL GEDDER; EMERY, FLAVIO DA SILVA. Strategies towards expansion of chemical space of natural product-based compounds to enable drug discovery. Brazilian Journal of Pharmaceutical Sciences, v. 54, n. SI, 2018. (17/22001-0, 14/50265-3, 17/21146-4)

ORENHA, RENATO P.; VESSECCHI, RICARDO; GALEMBECK, SERGIO E.. The influence of the negative hyperconjugation is relevant for the analysis of the pi-pi{*} conjugation with the mono-substitution and di-substitution of H2C= by O= and/or HN= in trans-buta-1,3-diene?. STRUCTURAL CHEMISTRY, v. 29, n. 3, p. 847-857, JUN 2018. (11/20351-7, 14/23604-1, 08/02677-0, 15/15176-2, 09/08712-4, 14/50265-3)

VESSECCHI, RICARDO; BORGES, LETICIA DA SILVA; EMERY, FLAVIO DA SILVA; LOPES, NORBERTO PEPORINE. Understanding the fragmentation mechanisms of methoxy-, mesyl-, and tosyl-lapachol derivatives by computational chemistry and mass spectrometry analysis. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, v. 418, n. SI, p. 92-100, JUL 2017. (14/50265-3, 14/23604-1)

GOZALO-MARCILLA, MIGUEL; DA SILVA, RODRIGO MOREIRA; LOUREIRO LUNA, STELIO PACCA; DE OLIVEIRA, ALICE RODRIGUES; FONSECA, MARIANA WERNECK; LOPES, NORBERTO PEPORINE; TAYLOR, POLLY M.; PELLIGAND, LUDOVIC. A possible solution to model nonlinearity in elimination and distributional clearances with alpha(2)-adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, v. 42, n. 6, p. 738-744, NOV 2019. (14/50265-3, 10/08967-0, 17/01425-6, 14/00474-5)

DEMARQUE, DANIEL P.; CALLEJON, DANIEL R.; PINTO, LARISSA G.; GOUVEA, DAYANA R.; DE MORAES, NATALIA V.; LOPES, JOAO L. C.; LOPES, JOSE N. C.; LOPES, NORBERTO P.; GUARATINI, THAIS. Pharmacokinetic disposition of erythraline in rats after intravenous administration. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 29, n. 6, p. 773-777, NOV-DEC 2019. (14/50265-3, 14/18052-0)

BORGES, LETICIA DA SILVA; CARVALHO BATISTA, JOAO HENRIQUE; BOZZINI, LEANDRO; LOURENCO JR, CELSO DONIZETE; LOPES, NORBERTO PEPORINE; CLOSOSKI, GIULIANO CESAR; VESSECCHI, RICARDO. Are benzoylium and nitrilium ions produced from substituted 2-arene-2-oxazolines during mass spectrometry? A study based on density functional theory calculations, quantum theory of atoms in molecules, and electrospray ionization tandem mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 37, n. 4, p. 11-pg., 2023-02-28. (17/04819-5, 09/51812-0, 09/08281-3, 14/50265-3, 20/02207-5, 18/14150-8, 14/23604-1)

CLOSOSKI, GIULIANO C.; SOLDI, RAFAEL A.; DA SILVA, RODRIGO M.; GUARATINI, THAIS; LOPES, JOSE N. C.; PEREIRA, PAMELA R. R.; LOPES, JOAO L. C.; DOS SANTOS, THIAGO; MARTINS, RONALDO B.; COSTA, CRISTINA S.; et al. Tenofovir Disoproxil Fumarate: New Chemical Developments and Encouraging in vitro Biological Results for SARS-CoV-2. Journal of the Brazilian Chemical Society, v. 31, n. 8, p. 1552-1556, AUG 2020. (14/50265-3, 18/14150-8, 14/02438-6)

NETO, FAUSTO CARNEVALE; GUARATINI, THAIS; COLEPICOLO, PIO; GATES, PAUL J.; LOPES, NORBERTO PEPORINE. Characteristic product ions of acetylene carotenoids by electrospray and nanospray ionization tandem mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 34, n. 16, AUG 30 2020. (14/50265-3, 14/12343-2)

DEMARQUE, DANIEL P.; DA SILVA, RUI M. P.; SANTOS, LEANDRO F.; LEOPOLDINO, ANDREIA M.; ESPREAFICO, ENILZA M.; LOPES, NORBERTO P.. Cytotoxicity of Structurally Diverse Anthranoids and Correlation with Mechanism of Action and Side Effects. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, v. 21, p. 347-353, 2018. (14/50265-3, 14/18052-0)

PILON, ALAN CESAR; GU, HAIWEI; RAFTERY, DANIEL; BOLZANI, VANDERLAN DA SILVA; LOPES, NORBERTO PEPORINE; CASTRO-GAMBOA, IAN; CARNEVALE NETO, FAUSTO. Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates. Analytical Chemistry, v. 91, n. 16, p. 10413-10423, AUG 20 2019. (16/13292-8, 10/17935-4, 03/02176-7, 14/12343-2, 10/07564-9, 14/50265-3)

DA SILVA, RODRIGO M.; GUARATINI, THAIS; JIMENEZ, PAULA C.; FENICAL, WILLIAM; COSTA-LOTUFO, LETICIA V.; VESSECCHI, RICARDO; LOPES, NORBERTO P.. Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone. Journal of the Brazilian Chemical Society, v. 29, n. 5, p. 1162-1166, MAY 2018. (14/50265-3)

VELASCO-ALZATE, KAREN Y.; BAUERMEISTER, ANELIZE; TANGERINA, MARCELO M. P.; LOTUFO, TITO M. C.; FERREIRA, MARCELO J. P.; JIMENEZ, PAULA C.; PADILLA, GABRIEL; LOPES, NORBERTO P.; COSTA-LOTUFO, LETICIA V.. Marine Bacteria from Rocas Atoll as a Rich Source of Pharmacologically Active Compounds. MARINE DRUGS, v. 17, n. 12, DEC 2019. (14/50265-3, 15/17177-6)

FERNANDES, EDUARDO FELIPE ALVES; DE OLIVEIRA, ANDERSON R. M.; BARROS, VALERIA PRISCILA; GUARATINI, THAIS; LOPES, NORBERTO PEPORINE. Biomimetic Metabolism of Kaurenoic Acid Validated by Microsomal Reactions. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 30, n. 4, AUG 2020. (14/50265-3, 13/17658-9)

CREVELIN, EDUARDO J.; POSSATO, BRUNA; LOPES, JOAO L. C.; LOPES, NORBERTO P.; CROTTI, ANTONIO E. M.. Precursor Ion Scan Mode-Based Strategy for Fast Screening of Polyether lonophores by Copper-Induced Gas-Phase Radical Fragmentation Reactions. Analytical Chemistry, v. 89, n. 7, p. 3929-3936, APR 4 2017. (14/50265-3, 13/20094-0)

MOREIRA, FERNANDA L.; MARQUES, LUCAS M. M.; LOPES, NORBERTO P.; DE OLIVEIRA, ANDERSON R. M.. In vitro metabolism studies of natural products are crucial in the early development of medicines. PHYTOCHEMISTRY REVIEWS, v. 16, n. 2, p. 355-373, APR 2017. (13/04188-4, 13/16496-5, 16/07597-0, 14/50265-3)

SOUZA, AMAURI ALVES; VESSECCHI, RICARDO; CASTRO-GAMBOA, IAN; FURLAN, MAYSA. Combined use of tandem mass spectrometry and computational chemistry to study 2H-chromenes from Piper aduncum. Journal of Mass Spectrometry, v. 54, n. 7, p. 634-642, JUL 2019. (17/15014-8, 14/22239-8, 14/23604-1, 13/07600-3, 14/50265-3)

FUMAGALLI, FERNANDO; GIL DE MELO, SHAIANI MARIA; RIBEIRO, CAMILA MARINGOLO; SOLCIA, MARIANA CRISTINA; PAVAN, FERNANDO ROGERIO; EMERY, FLAVIO DA SILVA. Exploiting the furo [2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters, v. 29, n. 8, p. 974-977, APR 15 2019. (14/50265-3, 17/21146-4, 15/06588-5, 18/00163-0)

MAURO, M.; DE GRANDIS, R. A.; CAMPOS, M. L.; BAUERMEISTER, A.; PECCININI, R. G.; PAVAN, F. R.; LOPES, N. P.; DE MORAES, V, N.. Acid diterpenes from Copaiba oleoresin (Copaifera langsdorffii): Chemical and plasma stability and intestinal permeability using Caco-2 cells. Journal of Ethnopharmacology, v. 235, p. 183-189, MAY 10 2019. (14/50265-3)

NUNES, TULIO M.; OLDROYD, BENJAMIN P.; ELIAS, LARISSA G.; MATEUS, SIDNEI; TURATTI, IZABEL C.; LOPES, NORBERTO P.. Evolution of queen cuticular hydrocarbons and worker reproduction in stingless bees. NATURE ECOLOGY & EVOLUTION, v. 1, n. 7, JUL 2017. (13/09263-4, 14/50265-3, 13/01918-1)

DE LIMA BATISTA, ANA PAULA; DE OLIVEIRA-FILHO, ANTONIO G. S.; GALEMBECK, SERGIO EMANUEL. Computationally Designed 1,2,4-Triazolylidene-Derived N-Heterocyclic Olefins for CO2 Capture, Activation, and Storage. ACS OMEGA, v. 2, n. 1, p. 299-307, JAN 2017. (15/22203-6, 15/11714-0, 08/02677-0, 14/50265-3)

PERES, RAPHAEL S.; SANTOS, GABRIELA B.; CECILIO, NERRY T.; JABOR, VALQURIA A. P.; NIEHUES, MICHAEL; TORRES, BRUNA G. S.; BUQUI, GABRIELA; SILVA, CARLOS H. T. P.; DALLA COSTA, TERESA; LOPES, NORBERTO P.; et al. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. ARTHRITIS RESEARCH & THERAPY, v. 19, MAR 7 2017. (13/08216-2, 12/20990-2, 09/54014-7, 12/25075-0, 14/50265-3)

DEMARQUE, DANIEL P.; CALLEJON, DANIEL R.; DE OLIVEIRA, GIBSON G.; SILVA, DENISE B.; CAROLLO, CARLOS A.; LOPES, NORBERTO P.. The role of tannins as antiulcer agents: a fluorescence-imaging based study. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 28, n. 4, p. 425-432, JUL-AUG 2018. (14/50265-3, 14/18052-0)

DA SILVA, RODRIGO MOREIRA; CARRAO, DANIEL BLASCKE; HABENSCHUS, MAISA DANIELA; JIMENEZ, PAULA CHRISTINE; LOPS, NORBERTO PEPORINE; FENICAL, WILLIAM; COSTA-LOTUFO, LETICIA VERA; MORAES DE OLIVEIRA, ANDERSON RODRIGO. Prediction of seriniquinone-drug interactions by in vitro inhibition of human cytochrome P450 enzymes. TOXICOLOGY IN VITRO, v. 65, JUN 2020. (14/50265-3, 14/50945-4, 16/15680-5, 16/06366-5, 18/07534-4)

ORENHA, RENATO P.; GALEMBECK, SERGIO E.. How does the pH influences the Ru-NO coordination compounds?. International Journal of Quantum Chemistry, v. 119, n. 20, OCT 15 2019. (14/50265-3, 15/15176-2, 11/20351-7, 08/02677-0)

BRUNETTI, ANDRES E.; LYRA, MARIANA L.; MELO, WEILAN G. P.; ANDRADE, LAURA E.; PALACIOS-RODRIGUEZ, PABLO; PRADO, BARBARA M.; HADDAD, CELIO F. B.; PUPO, MONICA T.; LOPES, NORBERTO P.. Symbiotic skin bacteria as a source for sex-specific scents in frogs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 116, n. 6, p. 2124-2129, FEB 5 2019. (17/23725-1, 14/20915-6, 13/50741-7, 17/26162-8, 13/50954-0, 14/50265-3, 15/01001-6)

GUARATINI, T.; FEITOSA, L. G. P.; SILVA, D. B.; LOPES, N. P.; LOPES, J. L. C.; VESSECCHI, R.. Gas-phase dissociation study of erythrinian alkaloids by electrospray ionization mass spectrometry and computational methods. Journal of Mass Spectrometry, v. 52, n. 9, p. 571-579, SEP 2017. (11/13281-2, 14/50265-3, 14/23604-1)

GALEMBECK, SERGIO E.; CARAMORI, GIOVANNI F.; MISTURINI, ALECHANIA; GARCIA, LEONE C.; ORENHA, RENATO P.. Metal-Ligand Bonding Situation in Ruthenophanes Containing Multibridged Cyclophanes. Organometallics, v. 36, n. 18, p. 3465-3470, SEP 25 2017. (15/15176-2, 11/20351-7, 14/50265-3, 08/02677-0)

GOBBO-NETO, LEONARDO; BAUERMEISTER, ANELIZE; SAKAMOTO, HUMBERTO T.; GOUVEA, DAYANA R.; LOPES, JOAO LUIS C.; LOPES, NORBERTO P.. Spatial and Temporal Variations in Secondary Metabolites Content of the Brazilian Arnica Leaves (Lychnophora ericoides Mart., Asteraceae). Journal of the Brazilian Chemical Society, v. 28, n. 12, p. 2382-2390, DEC 2017. (14/20302-4, 14/50265-3)

PINA, EDIEIDIA S.; SILVA, DENISE B.; TEIXEIRA, SIMONE P.; COPPEDE, JULIANA S.; FURLAN, MAYSA; FRANCA, SUZELEI C.; LOPES, NORBERTO P.; PEREIRA, ANA MARIA S.; LOPES, ADRIANA A.. Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging. SCIENTIFIC REPORTS, v. 6, MAR 4 2016. (09/54098-6, 14/50265-3, 12/18031-7, 13/07349-9, 15/26066-3, 10/18132-2)

DE OLIVEIRA, GIBSON GOMES; CARNEVALE NETO, FAUSTO; DEMARQUE, DANIEL PECORARO; DE SOUSA PEREIRA-JUNIOR, JOSE ANTONIO; SAMPAIO PEIXOTO FILHO, ROMULO CESAR; DE MELO, SEBASTIAO JOSE; GUEDES DA SILVA ALMEIDA, JACKSON ROBERTO; CALLEGARI LOPES, JOAO LUIZ; LOPES, NORBERTO PEPORINE. Dereplication of Flavonoid Glycoconjugates from Adenocalymma imperatoris-maximilianii by Untargeted Tandem Mass Spectrometry-Based Molecular Networking. Planta Medica, v. 83, n. 7, p. 636-646, MAY 2017. (14/12343-2, 14/50265-3)

DE LIMA BATISTA, ANA P.; DE OLIVEIRA-FILHO, ANTONIO G. S.; GALEMBECK, SERGIO E.. Photophysical properties and the NO photorelease mechanism of a ruthenium nitrosyl model complex investigated using the CASSCF-in-DFT embedding approach. Physical Chemistry Chemical Physics, v. 19, n. 21, p. 13860-13867, JUN 7 2017. (15/22203-6, 15/11714-0, 08/02677-0, 14/50265-3)

DA SILVA, RICARDO R.; WANG, MINGXUN; NOTHIAS, LOUIS-FELIX; VAN DER HOOFT, JUSTIN J. J.; CARABALLO-RODRIGUEZ, ANDRES MAURICIO; FOX, EVAN; BALUNAS, MARCY J.; KLASSEN, JONATHAN L.; LOPES, NORBERTO PEPORINE; DORRESTEIN, PIETER C.. Propagating annotations of molecular networks using in silico fragmentation. PLOS COMPUTATIONAL BIOLOGY, v. 14, n. 4, APR 2018. (14/01884-2, 14/50265-3, 15/03348-3)

TEODORO, T. Q.; KOENIS, M. A. J.; GALEMBECK, S. E.; NICU, V. P.; BUMA, W. J.; VISSCHER, L.. Frequency Range Selection Method for Vibrational Spectra. Journal of Physical Chemistry Letters, v. 9, n. 23, p. 6878-6882, DEC 6 2018. (16/07787-4, 14/50265-3, 16/23165-3, 08/02677-0)

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MAURIZ MARQUES, LUCAS MACIEL; AGUIAR, FERNANDO ARMANI; DA SILVA, DENISE BRENTAN; CALLEJON, DANIEL ROBERTO; MORAES DE OLIVEIRA, ANDERSON RODRIGO; LOPES, NORBERTO PEPORINE; CALLEGARI LOPES, JOAO LUIS; GUARATINI, THAIS. Microsomal metabolism of erythraline: an anxiolitic spiroalkaloid. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 25, n. 5, p. 529-532, SEP-OCT 2015. (09/51812-0, 14/20302-4, 12/18031-7, 11/13281-2, 14/50265-3)

TRENTIN, DANIELLE S.; SILVA, DENISE B.; FRASSON, AMANDA P.; RZHEPISHEVSKA, OLENA; DA SILVA, MARCIA V.; PULCINI, ELINOR DE L.; JAMES, GARTH; SOARES, GABRIEL V.; TASCA, TIANA; RAMSTEDT, MADELEINE; et al. Natural Green Coating Inhibits Adhesion of Clinically Important Bacteria. SCIENTIFIC REPORTS, v. 5, FEB 6 2015. (14/50265-3, 12/18031-7, 09/54098-6)

BRAIDA, BENOIT; GALEMBECK, SERGIO E.; HIBERTY, PHILIPPE C.. Ozone and Other 1,3-Dipoles: Toward a Quantitative Measure of Diradical Character. JOURNAL OF CHEMICAL THEORY AND COMPUTATION, v. 13, n. 7, p. 3228-3235, JUL 2017. (08/02677-0, 14/50265-3)

MURIE, VALTER E.; MARQUES, LUCAS M. M.; SOUZA, GLORIA E. P.; OLIVEIRA, ANDERSON R. M.; LOPES, NORBERTO P.; CLOSOSKI, GIULIANO C.. Acetaminophen Prodrug: Microwave-Assisted Synthesis and in vitro Metabolism Evaluation by Mass Spectrometry. Journal of the Brazilian Chemical Society, v. 27, n. 6, p. 1121-1128, JUN 2016. (13/17658-9, 15/12811-9, 14/50265-3)

BUQUI, GABRIELA AMARAL; GOUVEA, DAYANA RUBIO; SY, SHERWIN K. B.; VOELKNER, ALEXANDER; SINGH, RAVI S. P.; DA SILVA, DENISE BRENTAN; KIMURA, ELZA; DERENDORF, HARTMUT; LOPES, NORBERTO PEPORINE; DINIZ, ANDREA. Pharmacokinetic Evaluation of Avicularin Using a Model-Based Development Approach. Planta Medica, v. 81, n. 5, p. 373-381, APR 2015. (14/50265-3)

DE LIMA BATISTA, ANA P.; DE OLIVEIRA-FILHO, ANTONIO G. S.; GALEMBECK, SERGIO E.. CO2 Sequestration by Triazolylidene-Derived N-Heterocyclic Olefins: A Computational Study. CHEMISTRYSELECT, v. 2, n. 17, p. 4648-4654, JUN 12 2017. (15/22203-6, 15/11714-0, 08/02677-0, 14/50265-3)

ORENHA, RENATO P.; ROCHA, MARCUS V. J.; POATER, JORDI; GALEMBECK, SERGIO E.; BICKELHAUPT, F. MATTHIAS. Nature of the Ru-NO Coordination Bond: Kohn-Sham Molecular Orbital and Energy Decomposition Analysis. CHEMISTRYOPEN, v. 6, n. 3, p. 410-416, JUN 2017. (15/15176-2, 11/20351-7, 14/50265-3, 08/02677-0)

PELEGRINI, M.; GALEMBECK, SERGIO E.. nderstanding the Fe-CO bond through the electronic structure of Fem+(CO)(6-n)L-n, m=2, 3, n=0-3, L = Cl-, Br-, H2O or NH. Journal of Molecular Modeling, v. 27, n. 5, MAY 2021. (17/04856-8, 08/02677-0, 14/50265-3, 12/50666-2)

BUENO, PAULA C. P.; LOPES, NORBERTO P.. Metabolomics to Characterize Adaptive and Signaling Responses in Legume Crops under Abiotic Stresses. ACS OMEGA, v. 5, n. 4, p. 1752-1763, FEB 4 2020. (14/50265-3, 17/19702-6, 19/08477-7)

LANCHOTI FIORI, GIOVANA MARIA; DEMARQUE, DANIEL PECORARO; SOARES PEREIRA, ANA MARIA; KLEIN, VERA L. G.; LOPES, NORBERTO PEPORINE. Cucurbitane Triterpene Glycosides from the Roots of Wilbrandia hibiscoides. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 31, n. 5, AUG 2021. (12/14408-9, 14/50265-3, 14/18052-0)

ORENHA, RENATO P.; VESSECCHI, RICARDO; GALEMBECK, SERGIO E.. The influence of the negative hyperconjugation is relevant for the analysis of the pi-pi* conjugation with the mono-substitution and di-substitution of H2C= by O= and/or HN= in trans-buta-1,3-diene?. STRUCTURAL CHEMISTRY, v. 29, n. 3, p. 11-pg., 2018-06-01. (08/02677-0, 09/08712-4, 14/50265-3, 15/15176-2, 14/23604-1, 11/20351-7)

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ODA, FERNANDO BOMBARDA; CARVALHO, FLAVIO ALEXANDRE; YAMAMOTO, PRISCILA AKEMI; DE OLIVEIRA, JONATA AUGUSTO; PECCININI, ROSANGELA GONCALVES; ZOCOLO, GUILHERME JULIAO; RIBEIRO, PAULO RICELI VASCONCELOS; DE MORAES, NATALIA VALADARES; DOS SANTOS, ANDRE GONZAGA. Metabolism Characterization and Chemical and Plasma Stability of Casearin B and Caseargrewiin F. Planta Medica, v. 89, n. 11, p. 9-pg., 2023-05-26. (14/50265-3)

SILVA, DANIEL GEDDER; EMERY, FLAVIO DA SILVA. Strategies towards expansion of chemical space of natural product-based compounds to enable drug discovery. Brazilian Journal of Pharmaceutical Sciences, v. 54, p. 16-pg., 2018-01-01. (14/50265-3, 17/21146-4, 17/22001-0)

CARNEVALE NETO, FAUSTO; GUARATINI, THAIS; COSTA-LOTUFO, LETICIA; COLEPICOLO, PIO; GATES, PAUL J.; LOPES, NORBERTO PEPORINE. Re-investigation of the fragmentation of protonated carotenoids by electrospray ionization and nanospray tandem mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 30, n. 13, p. 9-pg., 2016-07-15. (14/50265-3, 14/12343-2)

NETO, FAUSTO CARNEVALE; ANDREO, MARCIO ADRIANO; RAFTERY, DANIEL; CALLEGARI LOPES, JOAO LUIS; LOPES, NORBERTO PEPORINE; CASTRO-GAMBOA, IAN; DE NORONHA SALES MAIA, BEATRIZ HELENA LAMEIRO; COSTA, EMMANOEL VILACA; VESSECCHI, RICARDO. Characterization of aporphine alkaloids by electrospray ionization tandem mass spectrometry and density functional theory calculations. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 34, p. 11-pg., 2019-10-29. (09/08281-3, 14/50265-3, 14/12343-2, 14/23604-1, 10/07564-9, 03/02176-7)

VESSECCHI, RICARDO; BORGES, LETICIA DA SILVA; EMERY, FLAVIO DA SILVA; LOPES, NORBERTO PEPORINE. Understanding the fragmentation mechanisms of methoxy-, mesyl-, and tosyl-lapachol derivatives by computational chemistry and mass spectrometry analysis. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, v. 418, p. 9-pg., 2017-07-01. (14/23604-1, 14/50265-3)

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Filed patent(s) as a result of this research project