Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach

• Grant number: 13/50228-8
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
• Start date: November 01, 2014
• End date: October 31, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Roberto Gomes de Souza Berlinck
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• City of the host institution: São Carlos
• Principal investigators: André Gustavo Tempone Cardoso ; Edson Rodrigues Filho
• Associated research grant(s): 15/50075-2 - Brazilian biodiversity as a source for novel drug scaffolds against neglected protozoan diseases, AP.R SPRINT; 15/01017-0 - Multi-use instrument approved and awarded in the project 2013/50228-8, name of instrument: ultra-performance liquid chromatograph coupled with a high resolution mass spectrometer, AP.EMU
• Associated scholarship(s): 19/26892-1 - Natural inhibitors of Penicillin-Binding Proteins (PBPs) from marine microorganisms and invertebrates: isolation, identification and mechanism of action, BP.PD; 15/02820-0 - Synthesis of Antileishmanial and antiChagas agents for drug prototypal development, BP.PD; 14/17616-7 - Phylogenetic and functional characterization of microbial communities associated with sponges that present bromopyrrole alkaloids and characterization of gene clusters which include nonribossomal peptide synthetase (NRPS), BP.PD

Abstract

Islands represent about 5% of the Erath’s land cover. With a very particular biodiversity, islands are considered true microcosms of the continents. The islands’ natural environment very often present a variety of endemic species, which are particularly vulnerable. Therefore, the importance of biodiversity conservation of biological species present on islands is extreme. The marine biodiversity of the South Atlantic west coast, where Brazil is located, it is still essentially unknown. The anthropogenic impacts observed in the Brazilian coastal region are of increasing intensity. Coastal and oceanic Brazilian islands have submerged marine environments somewhat better preserved that the coastline ones. Taking into account the diversity of species estimated for such islands, the study of its biodiversity is most necessary and should be conducted jointly with bioprospecting activities. This project aims to answer four questions: 1. Macro-organics of different biological group (sponges, ascidians, cnidarians, bryozoans and mollusks) found in different islands of Brazil exhibit a distinct pattern of occurrence or distribution than at the coastline? 2. Micro-organisms associated with invertebrates and with plant islands exhibit an occurrence of species different from that observed in coastal environments? 3. Among the macro- and micro-organisms that will be chemically, biochemically and biotechnologically investigated, are their secondary metabolites and enzimes characteristically unique of organisms found on islands and archipelagos, due to relative geographic isolation of the species present in these environments, or have biogenetic relationships and/or occurrences or similar biochemical characters of related species found on the continent? 4. The frequency of the occurrence of bioactive substances in organisms from islands is higher than in organisms from the coasts? In order to answer such questions, fauna surveys associated with studies of biodiversity, taxonomy, phylogeography, bioprospecting, microbiology and metagenomic analyses will be performed. Particular emphasis will be applied to the survey and description of invertebrate species to be found in sites still poorly explored. Such strategy aims: the isolation of “exotic” microbial strains using different approaches for growth in culture media; the isolation of novel bioactive metabolites using dereplication tools and refined analyses of chemical profiles (by UPLC-UV-MS/MS); the investigation of specific cases of micr-organism/macro-organism interactions that may be related to metabolism expression of one or both parties, using metagenomic techniques associated with metabolomics analyses of specific biological groups. (AU)

Scientific publications

(70)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA CRUZ, RICHTIER GONCALVES; BENEY, LAURENT; GERVAIS, PATRICK; DE LIRA, SIMONE POSSEDENTE; FERREIRA DE SOUZA VIEIRA, THAIS MARIA; DUPONT, SEBASTIEN. Comparison of the antioxidant property of acerola extracts with synthetic antioxidants using an in vivo method with yeasts. Food Chemistry, v. 277, p. 698-705, MAR 30 2019. (13/50228-8)

ELIAS, LUCIANA M.; FORTLZAMP, DIANA; SARTORI, SERGIO B.; FERREIRA, MARILIA C.; GOMES, LUIZ H.; AZEVEDO, JOAO L.; MONTOYA, V, QUIMI; RODRIGUES, ANDRE; FERREIRA, ANTONIO G.; LIRA, SIMONE P.. The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnose. Brazilian Journal of Microbiology, v. 49, n. 4, p. 840-847, OCT-DEC 2018. (14/05940-4, 14/15760-3, 12/02000-5, 13/50228-8)

GUBIANI, JULIANA R.; OLIVEIRA, MICHELE C. S.; NEPONUCENO, RICARDO A. R.; CAMARGO, MARIA J.; GARCEZ, WALMIR S.; BIZ, ANDRESSA R.; SOARES, MARCOS A.; ARAUJO, ANGELA R.; BOLZANI, VANDERLAN DA S.; LISBOA, HELEN C. F.; et al. Cytotoxic prenylated indole alkaloid produced by the endophytic fungus Aspergillus terreus P63. PHYTOCHEMISTRY LETTERS, v. 32, p. 162-167, AUG 2019. (13/50228-8, 14/25222-9)

FERREIRA, EVERTON L. F.; WILLIAMS, DAVID E.; IOCA, LAURA P.; MORAIS-URANO, RAQUEL P.; SANTOS, MARIO F. C.; PATRICK, BRIAN O.; ELIAS, LUCIANA M.; LIRA, SIMONE P.; FERREIRA, ANTONIO G.; PASSARINI, MICHEL R. Z.; et al. Structure and Biogenesis of Roussoellatide, a Dichlorinated Polyketide from the Marine-Derived Fungus Roussoella sp DLM33. ORGANIC LETTERS, v. 17, n. 21, p. 5152-5155, NOV 6 2015. (12/50026-3, 13/50228-8)

SLIVINSKI, JULIANO; SANTOS, MARIO F. C.; FERREIRA, ANTONIO G.; BERLINCK, ROBERTO G. S.. Brotasic Acid Methyl Ester from the Fruiting Bodies of the Mushroom Auricularia sp. PHYTOCHEMISTRY LETTERS, v. 29, p. 91-93, FEB 2019. (13/50228-8)

THOMPSON, FABIANO; KRUGER, RICARDO; THOMPSON, CRISTIANE C.; BERLINCK, ROBERTO G. S.; COUTINHO, RICARDO; LANDELL, MELISSA F.; PAVAO, MAURO; MOURAO, PAULO A. S.; SALLES, ANA; NEGRI, NAIANE; et al. Marine Biotechnology in Brazil: Recent Developments and Its Potential for Innovation. FRONTIERS IN MARINE SCIENCE, v. 5, JUL 9 2018. (12/19419-9, 13/50228-8)

LAURA P. IÓCA; STELAMAR ROMMINGER; MARIO F. C. SANTOS; KARIN F. BANDEIRA; FABIANA T. RODRIGUES; MIRIAM H. KOSSUGA; KAREN J. NICACIO; EVERTON L. F. FERREIRA; RAQUEL P. MORAIS-URANO; MESSIAS S. PASSOS; et al. A STRATEGY FOR THE RAPID IDENTIFICATION OF FUNGAL METABOLITES AND THE DISCOVERY OF THE ANTIVIRAL ACTIVITY OF PYRENOCINE A AND HARZIANOPYRIDONE. Química Nova, v. 39, n. 6, p. 720-731, 2016-07-00. (10/50190-2, 13/50228-8, 11/08064-2, 08/00331-9, 13/23153-7)

DE CASTRO, MARCOS V.; IOCA, LAURA P.; WILLIAMS, DAVID E.; COSTA, BRUNA Z.; MIZUNO, CAROLINA M.; SANTOS, MARIO F. C.; DE JESUS, KAREN; FERREIRA, EVERTON L. F.; SELEGHIM, MIRNA H. R.; SETTE, LARA D.; et al. Condensation of Macrocyclic Polyketides Produced by Penicillium sp DRF2 with Mercaptopyruvate Represents a New Fungal Detoxification Pathway. Journal of Natural Products, v. 79, n. 6, p. 1668-1678, JUN 2016. (05/60175-2, 10/50190-2, 12/50026-3, 13/50228-8)

GRECCO, SIMONE S.; COSTA-SILVA, THAIS A.; JERZ, GEROLD; DE SOUSA, FERNANDA S.; LONDERO, VINICIUS S.; GALUPPO, MARIANA K.; LIMA, MARTA L.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; TEMPONE, ANDRE G.; et al. Neolignans from leaves of Nectandra leucantha (Lauraceae) display in vitro antitrypanosomal activity via plasma membrane and mitochondrial damages. Chemico-Biological Interactions, v. 277, p. 55-61, NOV 1 2017. (15/50075-2, 15/11936-2, 13/50228-8)

CORREIA, ANA M. L.; LIRA, SIMONE P.; ASSIS, MARCO A.; RODRIGUES, ANDRE. Fungal Endophyte Communities in Begonia Species from the Brazilian Atlantic Rainforest. Current Microbiology, v. 75, n. 4, p. 441-449, APR 2018. (14/15760-3, 14/12021-5, 13/50228-8)

MARCIANO CORREA, JOZE APARECIDA; FORTKAMP, DIANA; DA SILVA, CAMILA FURTUNATO; ROCHA, FLAVIO; GOMES, LUIZ HUMBERTO; RONCATO DUARTE, KEILA MARIA; FERREIRA, ANTONIO GILBERTO; DE LIRA, SIMONE POSSEDENTE. Biological activity of 7 beta-acetoxywithanolide D isolated from Acnistus arborescens. SEMINA-CIENCIAS AGRARIAS, v. 39, n. 6, p. 2835-2841, NOV-DEC 2018. (12/02861-0, 13/50228-8, 14/15760-3, 11/09349-0)

KURODA, YUSUKE; NICACIO, KAREN J.; DA SILVA-, JR., ILDEFONSO ALVES; LEGER, PAUL R.; CHANG, STANLEY; GUBIANI, JULIANA R.; DEFLON, VICTOR M.; NAGASHIMA, NOZOMU; RODE, ALEXANDER; BLACKFORD, KATHERINE; et al. Isolation, synthesis and bioactivity studies of phomactin terpenoids. NATURE CHEMISTRY, v. 10, n. 9, p. 938-945, SEP 2018. (13/50228-8, 15/01017-0, 17/06014-4)

RUA, CINTIA P. J.; DE OLIVEIRA, LOUISI S.; FROES, ADRIANA; TSCHOEKE, DIOGO A.; SOARES, ANA CAROLINA; LEOMIL, LUCIANA; GREGORACCI, GUSTAVO B.; COUTINHO, RICARDO; HAJDU, EDUARDO; THOMPSON, CRISTIANE C.; et al. Microbial and Functional Biodiversity Patterns in Sponges that Accumulate Bromopyrrole Alkaloids Suggest Horizontal Gene Transfer of Halogenase Genes. MICROBIAL ECOLOGY, v. 76, n. 3, p. 825-838, OCT 2018. (14/17616-7, 13/50228-8)

NEWMISTER, SEAN A.; ROMMINGER, STELAMAR; SCHMIDT, JENNIFER J.; WILLIAMS, ROBERT M.; SMITH, JANET L.; BERLINCK, ROBERTO G. S.; SHERMAN, DAVID H.. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 16, n. 35, p. 6450-6459, SEP 21 2018. (13/50228-8, 14/05670-7, 12/50026-3)

RODRIGUEZ, JULIE P. G.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; DE OLIVEIRA, JULIANA MAGALHAES; MORAIS-URANO, RAQUEL P.; BERTONHA, ARIANE F.; BANDEIRA, KARIN F.; BULLA, JAIRO I. Q.; SETTE, LARA D.; FERREIRA, ANTONIO G.; et al. Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica. Journal of Natural Products, v. 83, n. 1, p. 55-65, JAN 2020. (13/23153-7, 16/21341-9, 17/06014-4, 13/50228-8, 16/16033-3)

IOCA, LAURA P.; NICACIO, KAREN J.; BERLINCK, ROBERTO G. S.. Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rewards. Journal of the Brazilian Chemical Society, v. 29, n. 5, p. 998-1031, MAY 2018. (16/05133-7, 13/50228-8)

ORR, RUSSELL J. S.; HAUGEN, MARIANNE N.; BERNING, BOEJRN; BOCK, PHILIP; CUMMING, ROBYN L.; FLORENCE, WAYNE K.; HIROSE, MASATO; DI MARTINO, EMANUELA; RAMSFJELL, MALI H.; SANNUM, MAJA M.; et al. A genome-skimmed phylogeny of a widespread bryozoan family, Adeonidae. BMC Evolutionary Biology, v. 19, n. 1, DEC 27 2019. (13/50228-8)

FREIRE, VITOR F.; SLIVINSKI, JULIANO; QUINTANA-BULLA, JAIRO I.; MORAES, FERNANDO C.; PARADAS, WLADIMIR C.; SALGADO, LEONARDO T.; PEREIRA, RENATO C.; MOURA, RODRIGO L.; AMADO-FILHO, GILBERTO M.; FERREIRA, ANTONIO G.; et al. Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 29, n. 6, p. 715-719, NOV-DEC 2019. (16/16033-3, 13/50228-8)

MAIMONE, NAYDJA MORALLES; DE OLIVEIRA, LUCIANNE FERREIRA PAES; SANTOS, SUIKINAI NOBRE; DE LIRA, SIMONE POSSEDENTE. Elicitation of Streptomyces lunalinharesii secondary metabolism through co-cultivation with Rhizoctonia solani. MICROBIOLOGICAL RESEARCH, v. 251, OCT 2021. (13/50228-8)

DOS REIS, GISLAINE VICENTE; ABRAHAM, WOLF-RAINER; GRIGOLETTO, DIANA FORTKAMP; DE CAMPOS, JESSICA BUENO; MARCON, JOELMA; DA SILVA, JOSE ANTONIO; QUECINE, MARIA CAROLINA; DE AZEVEDO, JOAO LUCIO; FERREIRA, ANTONIO GILBERTO; DE LIRA, SIMONE POSSEDENTE. Gloeosporiocide, a new antifungal cyclic peptide from Streptomyces morookaense AM25 isolated from the Amazon bulk soil. FEMS Microbiology Letters, v. 366, n. 14, JUL 2019. (13/50228-8, 14/15760-3)

KAHLERT, LUKAS; BERNARDI, DARLON; HAUSER, MAURICE; IOCA, LAURA P.; BERLINCK, ROBERTO G. S.; SKELLAM, ELIZABETH J.; COX, RUSSELL J.. Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products. CHEMISTRY-A EUROPEAN JOURNAL, v. 27, n. 46, p. 11895-11903, AUG 16 2021. (16/05133-7, 18/10742-8, 16/21341-9, 13/50228-8, 20/11691-8, 19/17721-9)

VARELA, MARINA T.; LIMA, MARTA L.; GALUPPO, MARIANA K.; TEMPONE, ANDRE G.; DE OLIVEIRA, ALBERTO; LAGO, JOAO HENRIQUE G.; FERNANDES, JOAO PAULO S.. New alkenyl derivative from Piper malacophyllum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum. CHEMICAL BIOLOGY & DRUG DESIGN, v. 90, n. 5, p. 1007-1011, NOV 2017. (12/18756-1, 13/50228-8, 15/11936-2, 16/00195-4)

ANDREOTE, FERNANDO DINI; PEREIRA E SILVA, MICHELE DE CASSIA. Microbial communities associated with plants: learning from nature to apply it in agriculture. Current Opinion in Microbiology, v. 37, p. 29-34, JUN 2017. (14/50320-4, 13/50353-7, 13/50228-8)

NEWMISTER, SEAN A.; GOBER, CLAIRE M.; ROMMINGER, STELAMAR; YU, FENGAN; TRIPATHI, ASHOOTOSH; PARRA, LIZBETH LORENA L.; WILLIAMS, ROBERT M.; BERLINCK, ROBERTO G. S.; JOULLIE, MADELEINE M.; SHERMAN, DAVID H.. OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30. Journal of the American Chemical Society, v. 138, n. 35, p. 11176-11184, SEP 7 2016. (12/50026-3, 14/05670-7, 13/50228-8)

DA CRUZ, RICHTIER GONCALVES; BENEY, LAURENT; GERVAIS, PATRICK; DE LIRA, SIMONE POSSEDENTE; FERREIRA DE SOUZA VIEIRA, THAIS MARIA; DUPONT, SEBASTIEN. Comparison of the antioxidant property of acerola extracts with synthetic antioxidants using an in vivo method with yeasts. Food Chemistry, v. 277, p. 8-pg., 2019-03-30. (13/50228-8)

GALLO, RAFAEL D. C.; MOMO, PATRICIA B.; DAY, DAVID P.; BURTOLOSO, ANTONIO C. B.. Catalytic Friedel-Crafts Alkylation of Electron Rich Aromatic Derivatives with alpha-Aryl Diazoacetates Mediated by Bronsted Acids. ORGANIC LETTERS, v. 22, n. 6, p. 2339-2343, MAR 20 2020. (09/54040-8, 13/50228-8, 15/22003-7, 19/05002-8)

BERLINCK, ROBERTO G. S.; CRNKOVIC, CAMILA M.; GUBIANI, JULIANA R.; BERNARDI, DARLON I.; IOCA, LAURA P.; QUINTANA-BULLA, JAIRO I.. The isolation of water-soluble natural products - challenges, strategies and perspectives. NATURAL PRODUCT REPORTS, OCT 2021. (13/50228-8, 16/16033-3, 19/00447-1, 20/11691-8, 16/05133-7, 17/06014-4, 16/21341-9, 18/10742-8)

TONON, LUCIANE A. CHIMETTO; RUA, CINTIA; CRNKOVIC, CAMILA M.; BERNARDI, I, DARLON; JUNIOR, OSMINDO R. PIRES; HADDAD, CELIO F. B.; PEDROSA, CAROLINADA S. G.; SOUZA, LETICIA R. Q.; REHEN, STEVENS K.; DE AZEVEDO, GUSTAVO P. R.; et al. Microbiome associated with the tetrodotoxin-bearing anuran Brachycephalus pitanga. Toxicon, v. 203, p. 139-146, NOV 2021. (13/50741-7, 16/14375-4, 16/05133-7, 17/06014-4, 13/50228-8, 16/21341-9, 19/00447-1)

DOMINGOS, LEVY T. S.; SANTOS, MARIO F. C.; DE MORAES, DANIEL C.; DE SA, LEANDRO F. R.; DA SILVA, VINICIUS A. D.; MEUREN, LANA M.; BERLINCK, ROBERTO G. S.; FERREIRA-PEREIRA, ANTONIO. Batzelladine D and norbatzelladine L purified from marine sponge Monanchora arbuscula induce the reversal of fluconazole. BIOORGANIC CHEMISTRY, v. 105, DEC 2020. (13/50228-8)

COSTA, JONAS HENRIQUE; BAZIOLI, JAQUELINE MORAES; BARBOSA, LUIDY DARLLAN; THEODORO DOS SANTOS JUNIOR, PEDRO LUIS; REIS, FLAVIA C. G.; KLIMECK, TABATA; CRNKOVIC, CAMILA MANOEL; BERLINCK, ROBERTO G. S.; SUSSULINI, ALESSANDRA; RODRIGUES, MARCIO L.; et al. Phytotoxic Tryptoquialanines Produced In Vivo by Penicillium digitatum Are Exported in Extracellular Vesicles. MBIO, v. 12, n. 1, JAN-FEB 2021. (17/24462-4, 13/50228-8, 19/06359-7, 15/01017-0, 19/11563-2)

DE BARROS, RODOLFO CORREA; DA ROCHA, ROSANA MOREIRA. Two new species of Styela (Tunicata: Ascidiacea) from the tropical West Atlantic Ocean. Zootaxa, v. 4948, n. 2, p. 275-286, MAR 19 2021. (13/50228-8)

LEAL, CAMILLE, V; AVELINO-ALVES, DHARA; SALAZAR, VINICIUS; OMACHI, CLAUDIA; THOMPSON, CRISTIANE; BERLINCK, ROBERTO G. S.; HAJDU, EDUARDO; THOMPSON, FABIANO. Sponges present a core prokaryotic community stable across Tropical Western Atlantic. Science of The Total Environment, v. 835, p. 15-pg., 2022-04-29. (19/17721-9, 15/01017-0, 13/50228-8)

RAMIREZ, MARIA CAMILA A.; WILLIAMS, DAVID E.; GUBIANI, JULIANA R.; PARRA, LIZBETH L. L.; SANTOS, MARIO F. C.; FERREIRA, DAIANE D.; MESQUITA, JULIANA T.; TEMPONE, ANDRE G.; FERREIRA, ANTONIO G.; PADULA, VINICIUS; et al. Rearranged Terpenoids from the Marine Sponge Darwinella cf. oxeata and Its Predator, the Nudibranch Felimida grahami. Journal of Natural Products, v. 80, n. 3, p. 6-pg., 2017-03-01. (15/01017-0, 13/50228-8)

DA CRUZ, RICHTIER GONCALVES; FERREIRA DE SOUZA VIEIRA, THAIS MARIA; DE LIRA, SIMONE POSSEDENTE. Potential antioxidant of brazilian coffee from the region of Cerrado. FOOD SCIENCE AND TECHNOLOGY, v. 38, n. 3, p. 447-453, JUL-SEP 2018. (14/15760-3, 13/50228-8)

KAHLERT, LUKAS; BERNARDI, DARLON; HAUSER, MAURICE; IOCA, LAURA P.; BERLINCK, ROBERTO G. S.; SKELLAM, ELIZABETH J.; COX, RUSSELL J.. Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products. CHEMISTRY-A EUROPEAN JOURNAL, JUN 2021. (19/17721-9, 18/10742-8, 16/05133-7, 16/21341-9, 13/50228-8, 20/11691-8)

RAMIREZ, MARIA CAMILA A.; WILLIAMS, DAVID E.; GUBIANI, JULIANA R.; PARRA, LIZBETH L. L.; SANTOS, MARIO F. C.; FERREIRA, DAIANE D.; MESQUITA, JULIANA T.; TEMPONE, ANDRE G.; FERREIRA, ANTONIO G.; PADULA, VINICIUS; et al. Rearranged Terpenoids from the Marine Sponge Darwinella cf. oxeata and Its Predator, the Nudibranch Felimida grahami. Journal of Natural Products, v. 80, n. 3, SI, p. 720-725, MAR 2017. (15/01017-0, 13/50228-8)

MARTINS, DANUBIA BATISTA; VIEIRA, MAIRA RAMOS; FADEL, VALMIR; CAMARGO SANTANA, VIVIANE APARECIDA; RODRIGUES GUERR, MIRIAN ELISA; LIMA, MARTA LOPES; TEMPONE, ANDRE G.; DOS SANTOS CABRERA, MARCIA PEREZ. Membrane targeting peptides toward antileishmanial activity: Design, structural determination and mechanism of interaction. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 11, A, p. 2861-2871, NOV 2017. (15/17331-5, 12/24259-0, 14/11877-3, 14/08372-7, 13/50228-8)

AZEVEDO, GUSTAVO P. R.; MATTSSON, HANNAH K.; APPOLINARIO, LUCIANA R.; CALEGARIO, GABRIELA; LEOMIL, LUCIANA; WALTER, JULINE M.; CAMPEAO, MARIANA; CHIMETTO TONON, LUCIANE A.; MOREIRA, ANA PAULA B.; VIDAL, LIVIA; et al. Enterovibrio baiacu sp. nov.. Current Microbiology, OCT 2019. (13/50228-8, 16/14375-4)

GRIGOLETTO, DIANA F.; TRIVELLA, DANIELA B. B.; TEMPONE, ANDRE G.; RODRIGUES, ANDRE; CORREIA, ANA MARIA L.; LIRA, SIMONE P.. Antifungal compounds with anticancer potential from Trichoderma sp. P8BDA1F1, an endophytic fungus from Begonia venosa. Brazilian Journal of Microbiology, v. 51, n. 3, APR 2020. (14/10753-9, 14/15760-3, 13/50228-8, 14/12021-5)

TAKAKI, MIRELLE; WILLIAMS, DAVID E.; FREIRE, VITOR F.; SARTORI, SERGIO B.; LIRA, SIMONE P.; BIZARRIA JR, RODOLFO; RODRIGUES, ANDRE; DA COSTA, DANIELLE R. GONCALVES; AMORIM, MARCELO R. .; FERREIRA, ANTONIO G.; et al. Metabolomics Reveals a 26-Membered Macrolactone Produced by Endophytic Colletotrichum spp. from Alcatrazes Island, Brazil. ORGANIC LETTERS, v. N/A, p. 5-pg., 2022-12-15. (20/01229-5, 13/50228-8, 18/03679-8, 15/14114-3, 19/17721-9)

CHIMETTO TONON, LUCIANE A.; DE AZEVEDO, GUSTAVO P. R.; MONTEIRO, AFIF F.; BERNARDI, I, DARLON; GUBIANI, JULIANA R.; IOCA, LAURA P.; MATTSSON, HANNAH K.; MOREIRA, ANA PAULA B.; GOMES, ALEXANDRE F.; PIRES JUNIOR, OSMINDO R.; et al. New tetrodotoxin analogs in Brazilian pufferfishes tissues and microbiome. Chemosphere, v. 242, MAR 2020. (13/50228-8, 16/14375-4)

BERLINCK, ROBERTO G. S.; MONTEIRO, AFIF F.; BERTONHA, ARIANE F.; BERNARDI, DARLON I.; GUBIANI, JULIANA R.; SLIVINSKI, JULIANO; MICHALISKI, LAMONIELLI F.; TONON, LUCIANE A. C.; VENANCIO, VICTOR A.; FREIRE, VITOR F.. Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products. NATURAL PRODUCT REPORTS, v. 36, n. 7, p. 981-1004, JUL 1 2019. (16/21341-9, 17/06014-4, 16/14375-4, 16/11949-0, 13/50228-8, 17/25100-9)

DA COSTA-SILVA, THAIS ALVES; GALISTEO, JR., ANDRES JIMENEZ; LAULETTA LINDOSO, JOSE ANGELO; BARBOSA, LEANDRO R. S.; TEMPONE, ANDRE GUSTAVO. Nanoliposomal Buparvaquone Immunomodulates Leishmania infantum-Infected Macrophages and Is Highly Effective in a Murine Model. Antimicrobial Agents and Chemotherapy, v. 61, n. 4, APR 2017. (15/15822-1, 15/23403-9, 13/07275-5, 13/50228-8)

NICACIO, KAREN J.; IOCA, LAURA P.; FROES, ADRIANA M.; LEOMIL, LUCIANA; APPOLINARIO, LUCIANA R.; THOMPSON, CHRISTIANE C.; THOMPSON, FABIANO L.; FERREIRA, ANTONIO G.; WILLIAMS, DAVID E.; ANDERSEN, RAYMOND J.; et al. Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges. Journal of Natural Products, v. 80, n. 2, p. 235-240, FEB 2017. (16/05133-7, 13/50228-8)

DE SOUZA, RENATA T. M. P.; FREIRE, VITOR F.; GUBIANI, JULIANA R.; FERREIRA, RAQUEL O.; TRIVELLA, DANIELA B. B.; MORAES, FERNANDO C.; PARADAS, WLADIMIR C.; SALGADO, LEONARDO T.; PEREIRA, RENATO C.; AMADO FILHO, GILBERTO M.; et al. Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a Dictyonella sp Marine Sponge Collected at the Amazon River Mouth. Journal of Natural Products, v. 81, n. 10, p. 2296-2300, OCT 2018. (13/50228-8)

ANDRADE, PEDRO AVELINO MAIA DE; SOUZA, ADIJAILTON JOSE DE; LIRA, SIMONE POSSEDENTE; ASSIS, MARCO ANTONIO; BERLINCK, ROBERTO G. S.; ANDREOTE, FERNANDO DINI. The bacterial and fungal communities associated with Anthurium ssp. leaves: Insights into plant endemism and microbe association. MICROBIOLOGICAL RESEARCH, v. 244, MAR 2021. (13/50228-8)

RODRIGUES-COSTA, FERNANDA; SLIVINSKI, JULIANO; IOCA, LAURA P.; BERTONHA, ARIANE F.; DE FELICIO, RAFAEL; DA CUNHA, MARCOS GUILHERME; DA MATA MADEIRA, PAULO VINICIUS; CAUZ, ANA C. G.; TRINDADE, DANIEL MARAGNO; FREIRE, VITOR F.; et al. Merulinic acid C overcomes gentamicin resistance in Enterococcus faecium. BIOORGANIC CHEMISTRY, v. 100, JUL 2020. (16/05133-7, 13/50228-8, 11/52067-6, 17/12436-9, 15/19906-5, 14/11980-9)

LUCIANE AUGUSTO DE AZEVEDO FERREIRA; PAULO P.G. PACHELLE; SANDRA VIEIRA PAIVA. On two species of Periclimenaeus Borradaile, 1915 (Caridea: Palaemonidae) from colonial tunicates in the southwestern Atlantic. Nauplius, v. 28, 2020-07-03. (13/50228-8)

BANZATO, THAIS P.; GUBIANI, JULIANA R.; BERNARDI, DARLON I.; NOGUEIRA, CLAUDIO R.; MONTEIRO, AFIF F.; JULIANO, FERNANDA F.; DE ALENCAR, SEVERINO M.; PILLI, RONALDO A.; DE LIMA, CAROLINA A.; LONGATO, GIOVANNA B.; et al. Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis. Journal of Natural Products, v. 83, n. 6, p. 1784-1793, JUN 26 2020. (13/24416-1, 17/06014-4, 16/06137-6, 13/50228-8)

CIAVATTA, MARIA LETIZIA; LEFRANC, FLORENCE; VIEIRA, LEANDRO M.; KISS, ROBERT; CARBONE, MARIANNA; VAN OTTERLO, WILLEM A. L.; LOPANIK, NICOLE B.; WAESCHENBACH, ANDREA. The Phylum Bryozoa: From Biology to Biomedical Potential. MARINE DRUGS, v. 18, n. 4, APR 2020. (13/50228-8)

CAIUBY, CLARICE A. D.; DE JESUS, MATHEUS P.; BURTOLOSO, ANTONIO C. B.. alpha-Imino Iridium Carbenes from Imidoyl Sulfoxonium Ylides: Application in the One-Step Synthesis of Indoles. Journal of Organic Chemistry, v. 85, n. 11, p. 7433-7445, JUN 5 2020. (09/54040-8, 13/50228-8, 17/23837-4, 17/23329-9)

PARRA, LIZBETH L. L.; BERTONHA, ARIANE F.; SEVERO, IVAN R. M.; AGUIAR, ANNA C. C.; DE SOUZA, GUILHERME E.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.; GRAZZIA, NATHALIA; COSTA, TABATA R.; MIGUEL, DANILO C.; et al. Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis. Journal of Natural Products, v. 81, n. 1, p. 188-202, JAN 2018. (15/24595-9, 13/07600-3, 14/21129-4, 13/50228-8)

WULSTEN, IMKE E.; COSTA-SILVA, THAIS A.; MESQUITA, JULIANA T.; LIMA, MARTA L.; GALUPPO, MARIANA K.; TANIWAKI, NOEMI N.; BORBOREMA, SAMANTA E. T.; DA COSTA, FERNANDO B.; SCHMIDT, THOMAS J.; TEMPONE, ANDRE G.. Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones. Molecules, v. 22, n. 5, MAY 2017. (12/18756-1, 13/50228-8)

RODRIGUEZ, JULIE P. G.; WILLIAMS, DAVID. E.; SABATER, ISADORA D.; BONUGLI-SANTOS, RAFAELA C.; SETTE, LARA D.; ANDERSEN, RAYMOND J.; BERLINCK, ROBERTO G. S.. The marine-derived fungus Tinctoporellus sp CBMAI 1061 degrades the dye Remazol Brilliant Blue R producing anthraquinones and unique tremulane sesquiterpenes. RSC ADVANCES, v. 5, n. 81, p. 66360-66366, 2015. (10/50190-2, 13/50228-8)

ALEXANDRE, TATIANA RODRIGUES; LIMA, MARTA LOPES; GALUPPO, MARIANA KOLOS; MESQUITA, JULIANA TONINI; DO NASCIMENTO, MATILIA ANA; DOS SANTOS, AUGUSTO LEONARDO; SARTORELLI, PATRICIA; PIMENTA, DANIEL CARVALHO; TEMPONE, ANDRE GUSTAVO. Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 23, n. 1, MAY 30 2017. (16/24985-4, 13/50228-8)

LEITE, DORA M. B.; FONSECA, CASSIO A.; LEAL, CAMILLE V.; HAJDU, EDUARDO. Two new species of Timea from the Southwest Atlantic (Timeidae, Demospongiae, Porifera). Zootaxa, v. 4034, n. 1, p. 161-181, OCT 28 2015. (13/50228-8)

MARTINS, LIGIA F.; MESQUITA, JULIANA T.; PINTO, ERIKA G.; COSTA-SILVA, THAIS A.; BORBOREMA, SAMANTA E. T.; GALISTEO JUNIOR, ANDRES J.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; AL SHUHAIB, ZAINAB; BENNETT, ELLIOT L.; et al. Analogues of Marine Guanidine Alkaloids Are in Vitro Effective against Trypanosoma cruzi and Selectively Eliminate Leishmania (L.) infantum Intracellular Amastigotes. Journal of Natural Products, v. 79, n. 9, p. 2202-2210, SEP 2016. (12/18756-1, 11/23703-1, 13/07275-5, 13/50228-8)

FROES, ADRIANA M.; FREITAS, THAMYRES C.; VIDAL, LIVIA; APPOLINARIO, LUCIANA R.; LEOMIL, LUCIANA; VENAS, TAINA; CAMPEAO, MARIANA E.; SILVA, CARLOS J. F.; MOREIRA, ANA PAULA B.; BERLINCK, ROBERTO G. S.; et al. Genomic Attributes of Novel Symbiont Pseudovibrio brasiliensis sp. nov. Isolated From the Sponge Arenosclera brasiliensis. FRONTIERS IN MARINE SCIENCE, v. 5, MAR 12 2018. (13/50228-8)

SANTOS, MARIO F. C.; HARPER, PHILIP M.; WILLIAMS, DAVID E.; MESQUITA, JULIANA T.; PINTO, ERIKA G.; DA COSTA-SILVA, THAIS A.; HAJDU, EDUARDO; FERREIRA, ANTONIO G.; SANTOS, RAQUEL A.; MURPHY, PATRICK J.; et al. Anti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge Monanchora arbuscula. Journal of Natural Products, v. 78, n. 5, p. 1101-1112, MAY 2015. (10/50190-2, 13/50228-8)

FARIAS, JAMILE; SOUZA, FACELUCIA B. C.; VIEIRA, LEANDRO M.; ALMEIDA, ANA C. S.. On some Smittinidae (Bryozoa, Cheilostomata) from Bahia, northeastern Brazil, with the description of a new species. MARINE BIODIVERSITY, v. 50, n. 5, AUG 18 2020. (13/50228-8)

LIMA, ANDREISA FABRI; RIBEIRO, LEANDRO DO PRADO; PADOAN GONCALVES, GABRIEL LUIZ; MAIMONE, NAYDJA MORALLES; GISSI, DANILO SOARES; DE LIRA, SIMONE POSSEDENTE; VENDRAMIM, JOSE DJAIR. Searching for bioactive compounds from Solanaceae: lethal and sublethal toxicity to Spodoptera frugiperda and untargeted metabolomics approaches. JOURNAL OF PEST SCIENCE, NOV 2021. (13/50228-8, 09/54094-0)

OLIVEIRA, LEANDRO DA SILVA; CRNKOVIC, CAMILA M. M.; DE AMORIM, MARCELO R. R.; NAVARRO-VAZQUEZ, ARMANDO; PAZ, TIAGO A. A.; FREIRE, VITOR F. F.; TAKAKI, MIRELLE; VENANCIO, TIAGO; FERREIRA, ANTONIO G. G.; SAITO, RENATA DE FREITAS; et al. Phomactinine, the First Nitrogen-Bearing Phomactin, Produced by Biatriospora sp. CBMAI 1333. Journal of Natural Products, v. N/A, p. 8-pg., 2023-07-25. (13/50228-8, 19/00447-1, 20/01229-5, 19/17721-9)

BERLINCK, ROBERTO G. S.; BERNARDI, I, DARLON; FILL, TAICIA; FERNANDES, ALESSANDRA A. G.; JURBERG, IGOR D.. The chemistry and biology of guanidine secondary metabolites. NATURAL PRODUCT REPORTS, v. 38, n. 3, p. 586-667, MAR 1 2021. (13/50228-8, 19/06359-7, 19/01235-8, 16/21341-9, 17/22164-6)

DA CRUZ, RICHTIER GONCALVES; FERREIRA DE SOUZA VIEIRA, THAIS MARIA; DE LIRA, SIMONE POSSEDENTE. Potential antioxidant of brazilian coffee from the region of Cerrado. FOOD SCIENCE AND TECHNOLOGY, v. 38, n. 3, p. 7-pg., 2018-07-01. (14/15760-3, 13/50228-8)

FREIRE, VITOR F.; GUBIANI, JULIANA R.; SPENCER, TARA M.; HAJDU, EDUARDO; FERREIRA, ANTONIO G.; FERREIRA, DAYANA A. S.; DE CASTRO LEVATTI, ERICA, V; BURDETTE, JOANNA E.; CAMARGO, CARLOS HENRIQUE; TEMPONE, ANDRE G.; et al. Feature-Based Molecular Networking Discovery of Bromopyrrole Alkaloids from the Marine Sponge Agelas dispar. Journal of Natural Products, v. 85, n. 5, p. 11-pg., 2022-05-27. (19/17721-9, 17/06014-4, 20/03637-3, 13/50228-8, 21/04464-8)

MARTINS, DANUBIA BATISTA; VIEIRA, MAIRA RAMOS; FADEL, VALMIR; CAMARGO SANTANA, VIVIANE APARECIDA; RODRIGUES GUERR, MIRIAN ELISA; LIMA, MARTA LOPES; TEMPONE, ANDRE G.; DOS SANTOS CABRERA, MARCIA PEREZ. Membrane targeting peptides toward antileishmanial activity: Design, structural determination and mechanism of interaction. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 11, p. 11-pg., 2017-11-01. (13/50228-8, 14/11877-3, 12/24259-0, 14/08372-7, 15/17331-5)

AZEVEDO, GUSTAVO P. R.; MATTSSON, HANNAH K.; APPOLINARIO, LUCIANA R.; CALEGARIO, GABRIELA; LEOMIL, LUCIANA; WALTER, JULINE M.; CAMPEAO, MARIANA; CHIMETTO TONON, LUCIANE A.; MOREIRA, ANA PAULA B.; VIDAL, LIVIA; et al. Enterovibrio baiacu sp. nov.. Current Microbiology, v. 77, n. 1, p. 4-pg., 2019-10-16. (16/14375-4, 13/50228-8)

GUBIANI, J. R.; BANZATO, T. P.; NOGUEIRA, C. R.; MONTEIRO, A. F.; DE ALENCAR, S. M.; PILLI, R. A.; DE CARVALHO, J. E.; BERLINCKA, R. G. S.. Unprecedented isoflavanoid-neoflavonoid analogues isolated from Brazilian red propolis. Planta Medica, v. 85, n. 18, p. 1-pg., 2019-12-01. (17/06014-4, 13/50228-8)

GUBIANI, JULIANA R.; BERNARDI, DARLON I.; DE PAULA, CAIO C. P.; SELEGHIM, MIRNA H. R.; FERREIRA, ANTONIO G.; BATISTA, ANDREA N. L.; BATISTA, JOAO M.; OLIVEIRA, LUCIANNE F. P.; LIRA, SIMONE P.; BURDETTE, JOANNA E.; et al. Absolute configuration of cytotoxic anthraquinones from a Brazilian cave soil-derived fungus, Aspergillus sp. SDC28. ARCHIV DER PHARMAZIE, v. 355, n. 4, p. 8-pg., 2022-01-31. (17/12436-9, 17/06014-4, 19/17721-9, 19/22319-5, 13/50228-8, 16/21341-9)

BARROS, ELCIO DANIEL SOUSA; MONCAO FILHO, EVALDO DOS SANTOS; PIO, YARA POLIANNA FONSECA; DE AMORIM, MARCELO RODRIGUES; BERLINCK, ROBERTO G. S.; MOURA, RITA DE CASSIA; FONSECA, MARILUCE GONCALVES; DANTAS, CLECIO; COELHO, RONALDO CUNHA; DA SILVA, GUILHERME RAMOS; et al. Comparative study of composition of methanolic extracts of the paratoid gland secretions (PGS) of Rhinella jimi (cururu toad) from northeastern Brazil: Gender, seasonality and geographic occurrence. Toxicon, v. 214, p. 10-pg., 2022-05-13. (19/17721-9, 20/01229-5, 13/50228-8, 15/01017-0)